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Protein

GTP-binding protein gtr1

Gene

gtr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GTPase. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168GTPSequence analysis
Nucleotide bindingi57 – 615GTPBy similarity
Nucleotide bindingi122 – 1254GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-165159. mTOR signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein gtr1
Gene namesi
Name:gtr1
ORF Names:SPBC337.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC337.13c.
PomBaseiSPBC337.13c. gtr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308GTP-binding protein gtr1PRO_0000372337Add
BLAST

Proteomic databases

MaxQBiO74824.

Interactioni

Subunit structurei

Component of the GSE complex.By similarity

Protein-protein interaction databases

BioGridi277470. 7 interactions.
MINTiMINT-4681008.

Structurei

3D structure databases

ProteinModelPortaliO74824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTR/RAG GTP-binding protein family.Curated

Phylogenomic databases

HOGENOMiHOG000173258.
InParanoidiO74824.
KOiK16185.
OMAiISHCQRK.
OrthoDBiEOG715QDR.
PhylomeDBiO74824.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006762. Gtr1_RagA.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11259. PTHR11259. 1 hit.
PfamiPF04670. Gtr1_RagA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O74824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKVLLMGR SGSGKSSMRS IVFSNYVAKD TRRLGATIDI EHSHVRFLGN
60 70 80 90 100
LVLNLWDCGG QEAFMENYLS AQRDHIFRNV QVLIYVFDVE SREFERDLVT
110 120 130 140 150
FRNCLEATVA NSPQARVFCL IHKMDLVQED LRDLVFEERK AILLETSKDL
160 170 180 190 200
ETTCLATSIW DETLFKAWSA IVYTLIPNTP TLESHLREFA KAAEAAEVIL
210 220 230 240 250
FERTTFLVIS SYSSESNPAT DAHRFEKISN IVKQFKLSCS KMQAQFTTFE
260 270 280 290 300
LRGGNFSAFI VPYTEDTYIL VVIADPEIES AVTLMNIQSA RRFIEASKSA

SDGIQLQP
Length:308
Mass (Da):35,010
Last modified:November 1, 1998 - v1
Checksum:i2399B9F3D1C05771
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21283.1.
PIRiT40266.
RefSeqiNP_595414.1. NM_001021321.2.

Genome annotation databases

EnsemblFungiiSPBC337.13c.1; SPBC337.13c.1:pep; SPBC337.13c.
GeneIDi2540954.
KEGGispo:SPBC337.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21283.1.
PIRiT40266.
RefSeqiNP_595414.1. NM_001021321.2.

3D structure databases

ProteinModelPortaliO74824.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277470. 7 interactions.
MINTiMINT-4681008.

Proteomic databases

MaxQBiO74824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC337.13c.1; SPBC337.13c.1:pep; SPBC337.13c.
GeneIDi2540954.
KEGGispo:SPBC337.13c.

Organism-specific databases

EuPathDBiFungiDB:SPBC337.13c.
PomBaseiSPBC337.13c. gtr1.

Phylogenomic databases

HOGENOMiHOG000173258.
InParanoidiO74824.
KOiK16185.
OMAiISHCQRK.
OrthoDBiEOG715QDR.
PhylomeDBiO74824.

Enzyme and pathway databases

ReactomeiR-SPO-165159. mTOR signalling.

Miscellaneous databases

NextBioi20802069.
PROiO74824.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006762. Gtr1_RagA.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11259. PTHR11259. 1 hit.
PfamiPF04670. Gtr1_RagA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGTR1_SCHPO
AccessioniPrimary (citable) accession number: O74824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.