Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot O74810 (UBC1_SCHPO)

Last modified November 25, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Ubiquitin-conjugating enzyme E2 1
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase 1
    Ubiquitin carrier protein 1
Gene names
Name: ubc1
ORF Names: SPBC2D10.20
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Hide | Top

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cytoplasm. Nucleus.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Hide | Top

Ontologies

Keywords

   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   Molecular functionLigase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processpost-translational protein modification

Inferred from electronic annotation. Source: InterPro

regulation of protein metabolic process

Inferred from electronic annotation. Source: InterPro

ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol Ref.2

Inferred from direct assay. Source: GeneDB_SPombe

nucleus Ref.2

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionubiquitin-protein ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Ubiquitin-conjugating enzyme E2 1
PRO_0000310742

Sites

Active site891Glycyl thioester intermediate By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
O74810-1 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: 4ACDEC0648676BE4

FASTA21724,507
        10         20         30         40         50         60 
MSDNRSRRIA KELADVQQDK QAGIQVWTIN DDISHLKGMF RGPEGTPYEG GYFVVDIEIP 

        70         80         90        100        110        120 
IDYPFRPPKM NFDTKIYHPN VSSQTGAICL DILKDQWSPV YTMKSALISL QSLLCTPEPS 

       130        140        150        160        170        180 
NPQDAQVAQV YLQNYQQFVR TAREWTSSYA AAPAGVDLDA ENTEFGGIDP NIITNLQQFG 

       190        200        210 
FSTELIVRVL QREHIKSQED LKDYPNGING ILDQLLH

« Hide

Hide | Top

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Hide | Top

Cross-references

Sequence databases

CU329671 Genomic DNA. Translation: CAA21178.2.
PIRT40123.
RefSeqNP_596239.1.

3D structure databases

HSSPHSSP built from PDB template 1FZY based on UniProtKB P21734.
ModBaseSearch...

Genome annotation databases

GeneID2540277.
KEGGspo:SPBC2D10.20.
NMPDRfig|4896.1.peg.2105.

Organism-specific databases

GeneDB_SpombeSPBC2D10.20.

Gene expression databases

ArrayExpressO74810.

Family and domain databases

InterProIPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PANTHERPTHR11621. UBQ-conjugat_E2. 1 hit.
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
ProDomPD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00212. UBCc. 1 hit.
[Graphical view]
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameUBC1_SCHPO
AccessionPrimary (citable) accession number: O74810
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 2000
Last modified: November 25, 2008
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents