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Protein

Myosin-51

Gene

myo51

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in cytokinesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi159 – 166ATPSequence analysis8

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • actin-dependent ATPase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • microfilament motor activity Source: PomBase
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: InterPro

GO - Biological processi

  • actin filament bundle convergence involved in mitotic contractile ring assembly Source: PomBase
  • actin filament bundle organization Source: PomBase
  • formin-nucleated actin cable assembly Source: PomBase
  • microtubule-based movement Source: InterPro
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • protein localization to actin fusion focus Source: PomBase

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-51
Alternative name(s):
Myosin type V-1
Gene namesi
Name:myo51
ORF Names:SPBC2D10.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2D10.14c
PomBaseiSPBC2D10.14c myo51

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234821 – 1471Myosin-51Add BLAST1471

Proteomic databases

MaxQBiO74805
PaxDbiO74805
PRIDEiO74805

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277087, 34 interactors
STRINGi4896.SPBC2D10.14c.1

Structurei

3D structure databases

ProteinModelPortaliO74805
SMRiO74805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 61Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST55
Domaini65 – 749Myosin motorPROSITE-ProRule annotationAdd BLAST685
Domaini753 – 773IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini776 – 796IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini801 – 821IQ 3PROSITE-ProRule annotationAdd BLAST21
Domaini824 – 844IQ 4PROSITE-ProRule annotationAdd BLAST21
Domaini849 – 869IQ 5PROSITE-ProRule annotationAdd BLAST21
Domaini872 – 892IQ 6PROSITE-ProRule annotationAdd BLAST21
Domaini1171 – 1417DilutePROSITE-ProRule annotationAdd BLAST247

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni628 – 650Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili909 – 952Sequence analysisAdd BLAST44

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOGENOMiHOG000171839
InParanoidiO74805
KOiK10357
OrthoDBiEOG092C04K7
PhylomeDBiO74805

Family and domain databases

CDDicd01380 MYSc_Myo5, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

O74805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHARLSVGS ECWVSNNNGH WDAARLIEIK DNGGGKVVAT VAKSSGVLET
60 70 80 90 100
VNYQQLQNRN IGQSESPSDL TNLPYLNEPS VLHALHNRYN NKQIYTYSGI
110 120 130 140 150
VLVSINPYQN LPEFYNDNLI KHFHKDPEAA KVPHLYSIAS SCYHALTTDS
160 170 180 190 200
KNQTIIVSGE SGAGKTVAAK YIMRYLTSVQ GVDHNGVVKR SVENQVLATN
210 220 230 240 250
PIMEAFGNAK TIRNDNSSRF GKYVTISFDE NLLITGANVN TYLLERSRVV
260 270 280 290 300
SLLKGERNYH IFYQLITGCT EEQRDKWFLE SASSFNYLSQ GNCDEISGVD
310 320 330 340 350
DSNDFTITCR ALSTIGISES RQEDVFCLLA ALLHLGNIEV CATRNEAQIQ
360 370 380 390 400
PGDGYLQKAA LLLGVDSSTL AKWIVKRQLK TRSETIITSS TLEHAISIRD
410 420 430 440 450
SVAKYLYSAL FLWIVHMINA SLDHNKVKRA AYKYIGVVDI YGFEHFEKNS
460 470 480 490 500
MEQFCINYAN EKLQQEFNKH VFKLEQEEYV KEGLDWRLIE YSDNQGCISL
510 520 530 540 550
IEDKLGILSL LDEECRLPSG NHQSFLQKLN NQLPTKHSQF YKKSRFNDGS
560 570 580 590 600
FMVKHYALDV SYQVHDFLAK NSDAIPDEFI SLLQNSKNEF ITYLLDFYMQ
610 620 630 640 650
LVSSQNKNPR KTAISRKPTL SSMFKSSLSQ LMTTVSSTNV HYIRCIKPNE
660 670 680 690 700
EKLPWTFSPP MVLSQLRACG VFETIRISSL GFPARFSYEE FAHRFRILLS
710 720 730 740 750
SKEWEEDNKK LTLNIVNSVI PHDNLNFQVG RSKIFFRSNV IGNFEEAHRA
760 770 780 790 800
TCSKSTVLLQ SAIRGFFTRK EYQRTVKFII KLQSVIMGWL TRQRFEREKI
810 820 830 840 850
ERAAILIQAH WRSYIQRKRY LSLIKCAIVI QSIVRKNIAY SRYINELRES
860 870 880 890 900
SATLLAKFWR AYNARKTFRG LKKSVIALQC VSRSVLTRRY LRRLQDSAGR
910 920 930 940 950
TSILYEKQKN LQASITEVSK QLKSNSKKVT VLRNKLNILN NSLSKWKCLI
960 970 980 990 1000
KKPSDFSEPV SMDFTSNDEQ LVQLLQAESK LRQASQQLYM AAKKSELGFV
1010 1020 1030 1040 1050
QSQTARENLS NYYQALQMTV SEKFEYDTEQ LPSRVLFYAM DRYFSIHKKL
1060 1070 1080 1090 1100
KQLLELVGVE NASLLPNEVV NKQTKDLLYE KRVVFLKQIK QALTVSSLFN
1110 1120 1130 1140 1150
AVGYKDGVMR LLETDQNSLL FAGVVNFLIF AGISLDLKTQ ISEFLSQLCS
1160 1170 1180 1190 1200
YFTKIVDGTV IENDKTLDFY EKPLQAVLYW FATLHKIRSF LVHLLSINSH
1210 1220 1230 1240 1250
GKQSVVEDLW NPLILKFSKH FSNLENSFHS LVQKLLSCCT EGSINALLNS
1260 1270 1280 1290 1300
KCLPEFIDAA DENTTPTGMN IYELIDRMNL IHKLLISSAL QPNLLELTIS
1310 1320 1330 1340 1350
HMLQHIGQRA FQTLIHGRSP YTWKSASQVS YNASLLINWC HQKGISYVNS
1360 1370 1380 1390 1400
SLLPLMQSPL VFCLRKNDAN DLDVILSVCN LLSPFEVVCL LNRYQPCAGE
1410 1420 1430 1440 1450
NPLPKSFSKA VEALSCKYKQ SGFTNGKITN TNGHAIPIAA SKNPLLSLEN
1460 1470
NHIYEELRLS ELINLLAKAT L
Length:1,471
Mass (Da):167,657
Last modified:November 1, 1998 - v1
Checksum:iC4079A033DE232ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21172.1
PIRiT40117
RefSeqiNP_596233.1, NM_001022153.2

Genome annotation databases

EnsemblFungiiSPBC2D10.14c.1; SPBC2D10.14c.1:pep; SPBC2D10.14c
GeneIDi2540560
KEGGispo:SPBC2D10.14c

Similar proteinsi

Entry informationi

Entry nameiMYO51_SCHPO
AccessioniPrimary (citable) accession number: O74805
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health