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Protein

Myosin-51

Gene

myo51

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Involved in cytokinesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi159 – 166ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microfilament motor activity Source: PomBase

GO - Biological processi

  • actin filament bundle organization Source: PomBase
  • formin-nucleated actin cable assembly Source: PomBase
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • protein localization to actin fusion focus Source: PomBase
  • regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly Source: PomBase
  • regulation of formin-nucleated actin cable assembly Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-51
Alternative name(s):
Myosin type V-1
Gene namesi
Name:myo51
ORF Names:SPBC2D10.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2D10.14c.
PomBaseiSPBC2D10.14c. myo51.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Component of the cytokinetic actin ring (CAR).

GO - Cellular componenti

  • actin fusion focus Source: PomBase
  • actomyosin contractile ring Source: PomBase
  • cell division site Source: PomBase
  • cytosol Source: PomBase
  • formin-nucleated actin cable Source: PomBase
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234821 – 1471Myosin-51Add BLAST1471

Proteomic databases

MaxQBiO74805.
PRIDEiO74805.

Interactioni

Protein-protein interaction databases

BioGridi277087. 30 interactors.
MINTiMINT-4680906.

Structurei

3D structure databases

ProteinModelPortaliO74805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 749Myosin motorAdd BLAST685
Domaini753 – 773IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini776 – 796IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini801 – 821IQ 3PROSITE-ProRule annotationAdd BLAST21
Domaini824 – 844IQ 4PROSITE-ProRule annotationAdd BLAST21
Domaini849 – 869IQ 5PROSITE-ProRule annotationAdd BLAST21
Domaini872 – 892IQ 6PROSITE-ProRule annotationAdd BLAST21
Domaini1171 – 1417DilutePROSITE-ProRule annotationAdd BLAST247

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili909 – 952Sequence analysisAdd BLAST44

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOGENOMiHOG000171839.
InParanoidiO74805.
KOiK10357.
OMAiEITHELC.
OrthoDBiEOG092C04K7.
PhylomeDBiO74805.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHARLSVGS ECWVSNNNGH WDAARLIEIK DNGGGKVVAT VAKSSGVLET
60 70 80 90 100
VNYQQLQNRN IGQSESPSDL TNLPYLNEPS VLHALHNRYN NKQIYTYSGI
110 120 130 140 150
VLVSINPYQN LPEFYNDNLI KHFHKDPEAA KVPHLYSIAS SCYHALTTDS
160 170 180 190 200
KNQTIIVSGE SGAGKTVAAK YIMRYLTSVQ GVDHNGVVKR SVENQVLATN
210 220 230 240 250
PIMEAFGNAK TIRNDNSSRF GKYVTISFDE NLLITGANVN TYLLERSRVV
260 270 280 290 300
SLLKGERNYH IFYQLITGCT EEQRDKWFLE SASSFNYLSQ GNCDEISGVD
310 320 330 340 350
DSNDFTITCR ALSTIGISES RQEDVFCLLA ALLHLGNIEV CATRNEAQIQ
360 370 380 390 400
PGDGYLQKAA LLLGVDSSTL AKWIVKRQLK TRSETIITSS TLEHAISIRD
410 420 430 440 450
SVAKYLYSAL FLWIVHMINA SLDHNKVKRA AYKYIGVVDI YGFEHFEKNS
460 470 480 490 500
MEQFCINYAN EKLQQEFNKH VFKLEQEEYV KEGLDWRLIE YSDNQGCISL
510 520 530 540 550
IEDKLGILSL LDEECRLPSG NHQSFLQKLN NQLPTKHSQF YKKSRFNDGS
560 570 580 590 600
FMVKHYALDV SYQVHDFLAK NSDAIPDEFI SLLQNSKNEF ITYLLDFYMQ
610 620 630 640 650
LVSSQNKNPR KTAISRKPTL SSMFKSSLSQ LMTTVSSTNV HYIRCIKPNE
660 670 680 690 700
EKLPWTFSPP MVLSQLRACG VFETIRISSL GFPARFSYEE FAHRFRILLS
710 720 730 740 750
SKEWEEDNKK LTLNIVNSVI PHDNLNFQVG RSKIFFRSNV IGNFEEAHRA
760 770 780 790 800
TCSKSTVLLQ SAIRGFFTRK EYQRTVKFII KLQSVIMGWL TRQRFEREKI
810 820 830 840 850
ERAAILIQAH WRSYIQRKRY LSLIKCAIVI QSIVRKNIAY SRYINELRES
860 870 880 890 900
SATLLAKFWR AYNARKTFRG LKKSVIALQC VSRSVLTRRY LRRLQDSAGR
910 920 930 940 950
TSILYEKQKN LQASITEVSK QLKSNSKKVT VLRNKLNILN NSLSKWKCLI
960 970 980 990 1000
KKPSDFSEPV SMDFTSNDEQ LVQLLQAESK LRQASQQLYM AAKKSELGFV
1010 1020 1030 1040 1050
QSQTARENLS NYYQALQMTV SEKFEYDTEQ LPSRVLFYAM DRYFSIHKKL
1060 1070 1080 1090 1100
KQLLELVGVE NASLLPNEVV NKQTKDLLYE KRVVFLKQIK QALTVSSLFN
1110 1120 1130 1140 1150
AVGYKDGVMR LLETDQNSLL FAGVVNFLIF AGISLDLKTQ ISEFLSQLCS
1160 1170 1180 1190 1200
YFTKIVDGTV IENDKTLDFY EKPLQAVLYW FATLHKIRSF LVHLLSINSH
1210 1220 1230 1240 1250
GKQSVVEDLW NPLILKFSKH FSNLENSFHS LVQKLLSCCT EGSINALLNS
1260 1270 1280 1290 1300
KCLPEFIDAA DENTTPTGMN IYELIDRMNL IHKLLISSAL QPNLLELTIS
1310 1320 1330 1340 1350
HMLQHIGQRA FQTLIHGRSP YTWKSASQVS YNASLLINWC HQKGISYVNS
1360 1370 1380 1390 1400
SLLPLMQSPL VFCLRKNDAN DLDVILSVCN LLSPFEVVCL LNRYQPCAGE
1410 1420 1430 1440 1450
NPLPKSFSKA VEALSCKYKQ SGFTNGKITN TNGHAIPIAA SKNPLLSLEN
1460 1470
NHIYEELRLS ELINLLAKAT L
Length:1,471
Mass (Da):167,657
Last modified:November 1, 1998 - v1
Checksum:iC4079A033DE232ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21172.1.
PIRiT40117.
RefSeqiNP_596233.1. NM_001022153.2.

Genome annotation databases

EnsemblFungiiSPBC2D10.14c.1; SPBC2D10.14c.1:pep; SPBC2D10.14c.
GeneIDi2540560.
KEGGispo:SPBC2D10.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21172.1.
PIRiT40117.
RefSeqiNP_596233.1. NM_001022153.2.

3D structure databases

ProteinModelPortaliO74805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277087. 30 interactors.
MINTiMINT-4680906.

Proteomic databases

MaxQBiO74805.
PRIDEiO74805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC2D10.14c.1; SPBC2D10.14c.1:pep; SPBC2D10.14c.
GeneIDi2540560.
KEGGispo:SPBC2D10.14c.

Organism-specific databases

EuPathDBiFungiDB:SPBC2D10.14c.
PomBaseiSPBC2D10.14c. myo51.

Phylogenomic databases

HOGENOMiHOG000171839.
InParanoidiO74805.
KOiK10357.
OMAiEITHELC.
OrthoDBiEOG092C04K7.
PhylomeDBiO74805.

Miscellaneous databases

PROiO74805.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO51_SCHPO
AccessioniPrimary (citable) accession number: O74805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.