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Protein

UV excision repair protein rhp23

Gene

rhp23

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.1 Publication
Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.1 Publication

GO - Molecular functioni

  • damaged DNA binding Source: PomBase
  • polyubiquitin binding Source: PomBase
  • ubiquitin binding Source: PomBase

GO - Biological processi

  • ER-associated ubiquitin-dependent protein catabolic process Source: PomBase
  • negative regulation of protein catabolic process Source: PomBase
  • nucleotide-excision repair Source: PomBase
  • protein ubiquitination Source: PomBase
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-5696395. Formation of Incision Complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
UV excision repair protein rhp23
Alternative name(s):
RAD23 homolog
Gene namesi
Name:rhp23
ORF Names:SPBC2D10.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2D10.12.
PomBaseiSPBC2D10.12. rhp23.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear envelope Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368UV excision repair protein rhp23PRO_0000114903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841Phosphoserine1 Publication
Modified residuei87 – 871Phosphoserine1 Publication
Modified residuei364 – 3641Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74803.

PTM databases

iPTMnetiO74803.

Interactioni

GO - Molecular functioni

  • polyubiquitin binding Source: PomBase
  • ubiquitin binding Source: PomBase

Protein-protein interaction databases

BioGridi277009. 36 interactions.
MINTiMINT-216365.

Structurei

3D structure databases

ProteinModelPortaliO74803.
SMRiO74803. Positions 321-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7777Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini135 – 18551UBA 1PROSITE-ProRule annotationAdd
BLAST
Domaini320 – 36041UBA 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 1224Poly-Ala
Compositional biasi205 – 2084Poly-Gln

Sequence similaritiesi

Contains 2 UBA domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000172162.
InParanoidiO74803.
KOiK10839.
OMAiVENMVEM.
OrthoDBiEOG092C4GFV.
PhylomeDBiO74803.

Family and domain databases

Gene3Di1.10.10.540. 1 hit.
InterProiIPR004806. Rad23.
IPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
IPR015360. XPC-bd.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
PF00240. ubiquitin. 1 hit.
PF09280. XPC-binding. 1 hit.
[Graphical view]
PRINTSiPR01839. RAD23PROTEIN.
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 2 hits.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF101238. SSF101238. 1 hit.
SSF46934. SSF46934. 2 hits.
SSF54236. SSF54236. 1 hit.
TIGRFAMsiTIGR00601. rad23. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLTFKNLQQ QKFVISDVSA DTKISELKEK IQTQQNYEVE RQKLIYSGRI
60 70 80 90 100
LADDKTVGEY NIKEQDFIVC MVSRPKTSTS TPKSAASPAP NPPASVPEKK
110 120 130 140 150
VEAPSSTVAE STSTTQTVAA AAPSNPDTTA TSEAPIDANT LAVGAQRNVA
160 170 180 190 200
VENMVEMGYE RSEVERAMRA AFNNPDRAVE YLLTGIPEDI LNRQREESAA
210 220 230 240 250
ALAAQQQQSE ALAPTSTGQP ANLFEQAALS ENENQEQPSN TVGDDPLGFL
260 270 280 290 300
RSIPQFQQLR QIVQQNPQML ETILQQIGQG DPALAQAITQ NPEAFLQLLA
310 320 330 340 350
EGAEGESALP SGGIQIQITQ EESESIDRLC QLGFDRNIVI QAYLACDKNE
360
ELAANYLFEH GHESEDEP
Length:368
Mass (Da):40,135
Last modified:November 1, 1998 - v1
Checksum:i5CE75EB7E190EFD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174293 mRNA. Translation: AAD51975.1.
CU329671 Genomic DNA. Translation: CAA21170.1.
PIRiT40115.
RefSeqiNP_596231.1. NM_001022151.2.

Genome annotation databases

EnsemblFungiiSPBC2D10.12.1; SPBC2D10.12.1:pep; SPBC2D10.12.
GeneIDi2540481.
KEGGispo:SPBC2D10.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174293 mRNA. Translation: AAD51975.1.
CU329671 Genomic DNA. Translation: CAA21170.1.
PIRiT40115.
RefSeqiNP_596231.1. NM_001022151.2.

3D structure databases

ProteinModelPortaliO74803.
SMRiO74803. Positions 321-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277009. 36 interactions.
MINTiMINT-216365.

PTM databases

iPTMnetiO74803.

Proteomic databases

MaxQBiO74803.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC2D10.12.1; SPBC2D10.12.1:pep; SPBC2D10.12.
GeneIDi2540481.
KEGGispo:SPBC2D10.12.

Organism-specific databases

EuPathDBiFungiDB:SPBC2D10.12.
PomBaseiSPBC2D10.12. rhp23.

Phylogenomic databases

HOGENOMiHOG000172162.
InParanoidiO74803.
KOiK10839.
OMAiVENMVEM.
OrthoDBiEOG092C4GFV.
PhylomeDBiO74803.

Enzyme and pathway databases

ReactomeiR-SPO-5696395. Formation of Incision Complex in GG-NER.

Miscellaneous databases

PROiO74803.

Family and domain databases

Gene3Di1.10.10.540. 1 hit.
InterProiIPR004806. Rad23.
IPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
IPR015360. XPC-bd.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
PF00240. ubiquitin. 1 hit.
PF09280. XPC-binding. 1 hit.
[Graphical view]
PRINTSiPR01839. RAD23PROTEIN.
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 2 hits.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF101238. SSF101238. 1 hit.
SSF46934. SSF46934. 2 hits.
SSF54236. SSF54236. 1 hit.
TIGRFAMsiTIGR00601. rad23. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHP23_SCHPO
AccessioniPrimary (citable) accession number: O74803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.