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Protein

UV excision repair protein rhp23

Gene

rhp23

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.1 Publication
Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.1 Publication

GO - Molecular functioni

  • damaged DNA binding Source: PomBase
  • polyubiquitin modification-dependent protein binding Source: PomBase
  • ubiquitin binding Source: PomBase

GO - Biological processi

  • negative regulation of protein catabolic process Source: PomBase
  • nucleotide-excision repair Source: PomBase
  • ubiquitin-dependent ERAD pathway Source: PomBase

Keywordsi

Biological processDNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-SPO-5696395 Formation of Incision Complex in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
UV excision repair protein rhp23
Alternative name(s):
RAD23 homolog
Gene namesi
Name:rhp23
ORF Names:SPBC2D10.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2D10.12
PomBaseiSPBC2D10.12 rhp23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149031 – 368UV excision repair protein rhp23Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84Phosphoserine1 Publication1
Modified residuei87Phosphoserine1 Publication1
Modified residuei364Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74803
PaxDbiO74803
PRIDEiO74803

PTM databases

iPTMnetiO74803

Interactioni

GO - Molecular functioni

  • polyubiquitin modification-dependent protein binding Source: PomBase
  • ubiquitin binding Source: PomBase

Protein-protein interaction databases

BioGridi277009, 38 interactors
MINTiO74803
STRINGi4896.SPBC2D10.12.1

Structurei

3D structure databases

ProteinModelPortaliO74803
SMRiO74803
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 77Ubiquitin-likePROSITE-ProRule annotationAdd BLAST77
Domaini135 – 185UBA 1PROSITE-ProRule annotationAdd BLAST51
Domaini320 – 360UBA 2PROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 122Poly-Ala4
Compositional biasi205 – 208Poly-Gln4

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000172162
InParanoidiO74803
KOiK10839
OMAiNFLFDQP
OrthoDBiEOG092C4GFV
PhylomeDBiO74803

Family and domain databases

Gene3Di1.10.10.540, 1 hit
InterProiView protein in InterPro
IPR004806 Rad23
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR015360 XPC-bd
IPR036353 XPC-bd_sf
PfamiView protein in Pfam
PF00627 UBA, 2 hits
PF00240 ubiquitin, 1 hit
PF09280 XPC-binding, 1 hit
PRINTSiPR01839 RAD23PROTEIN
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00165 UBA, 2 hits
SM00213 UBQ, 1 hit
SUPFAMiSSF101238 SSF101238, 1 hit
SSF46934 SSF46934, 2 hits
SSF54236 SSF54236, 1 hit
TIGRFAMsiTIGR00601 rad23, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

O74803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLTFKNLQQ QKFVISDVSA DTKISELKEK IQTQQNYEVE RQKLIYSGRI
60 70 80 90 100
LADDKTVGEY NIKEQDFIVC MVSRPKTSTS TPKSAASPAP NPPASVPEKK
110 120 130 140 150
VEAPSSTVAE STSTTQTVAA AAPSNPDTTA TSEAPIDANT LAVGAQRNVA
160 170 180 190 200
VENMVEMGYE RSEVERAMRA AFNNPDRAVE YLLTGIPEDI LNRQREESAA
210 220 230 240 250
ALAAQQQQSE ALAPTSTGQP ANLFEQAALS ENENQEQPSN TVGDDPLGFL
260 270 280 290 300
RSIPQFQQLR QIVQQNPQML ETILQQIGQG DPALAQAITQ NPEAFLQLLA
310 320 330 340 350
EGAEGESALP SGGIQIQITQ EESESIDRLC QLGFDRNIVI QAYLACDKNE
360
ELAANYLFEH GHESEDEP
Length:368
Mass (Da):40,135
Last modified:November 1, 1998 - v1
Checksum:i5CE75EB7E190EFD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174293 mRNA Translation: AAD51975.1
CU329671 Genomic DNA Translation: CAA21170.1
PIRiT40115
RefSeqiNP_596231.1, NM_001022151.2

Genome annotation databases

EnsemblFungiiSPBC2D10.12.1; SPBC2D10.12.1:pep; SPBC2D10.12
GeneIDi2540481
KEGGispo:SPBC2D10.12

Entry informationi

Entry nameiRHP23_SCHPO
AccessioniPrimary (citable) accession number: O74803
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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