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O74789 (YOU5_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative serine/threonine-protein phosphatase C26H8.05c

EC=3.1.3.16
Gene names
ORF Names:SPBC26H8.05c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandIron
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMMethylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Non-traceable author statement. Source: PomBase

   Cellular_componentcytosol

Inferred from direct assay Ref.2. Source: PomBase

nucleus

Inferred from direct assay Ref.2. Source: PomBase

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Putative serine/threonine-protein phosphatase C26H8.05c
PRO_0000310805

Sites

Active site1141Proton donor By similarity
Metal binding531Iron By similarity
Metal binding551Iron By similarity
Metal binding811Iron By similarity
Metal binding811Manganese By similarity
Metal binding1131Manganese By similarity
Metal binding1631Manganese By similarity
Metal binding2371Manganese By similarity

Amino acid modifications

Modified residue2721Phosphoserine Ref.3
Modified residue3481Leucine methyl ester By similarity

Sequences

Sequence LengthMass (Da)Tools
O74789 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 231850C214F6E2F6

FASTA34839,215
        10         20         30         40         50         60 
MTDLDLDWQL EELENGRLIP ESNVVELCQR VRDILIEESN IQWISSPVTI CGDIHGQLHD 

        70         80         90        100        110        120 
LLELFRIGGS CPGTKYLFLG DFVDRGFYSV ETFLLLLTLK CKYPKEMTLI RGNHESRQIT 

       130        140        150        160        170        180 
QVYGFYDECV RKYGSANVWR YCCEIFDYLS LGALVDGKVF CVHGGLSPSI SSIDQIRLLD 

       190        200        210        220        230        240 
RKQEVPHEGA MCDLLWSDPE DISGWGLSPR GAGFLFGADV SEVFNRANDL SFIARAHQLV 

       250        260        270        280        290        300 
MEGYKIHFSD KDKQYPKFTN EEDSELDSDS ASPVDDSPAP GDIITIPEKD KGSVVTVWSA 

       310        320        330        340 
PNYCYRCGNV ASILQLDENQ TQSFKIFGTA SQERSGIPTK RPIADYFL 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-272, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA21097.1.
PIRT40017.
RefSeqNP_596646.1. NM_001022568.2.

3D structure databases

ProteinModelPortalO74789.
SMRO74789. Positions 5-347.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277205. 40 interactions.
MINTMINT-4680772.
STRING4896.SPBC26H8.05c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC26H8.05c.1; SPBC26H8.05c.1:pep; SPBC26H8.05c.
GeneID2540680.
KEGGspo:SPBC26H8.05c.

Organism-specific databases

PomBaseSPBC26H8.05c.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172696.
KOK15423.
OMAVFNHRND.
OrthoDBEOG7FFN29.
PhylomeDBO74789.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801804.
PROO74789.

Entry information

Entry nameYOU5_SCHPO
AccessionPrimary (citable) accession number: O74789
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names