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O74789

- YOU5_SCHPO

UniProt

O74789 - YOU5_SCHPO

Protein

Putative serine/threonine-protein phosphatase C26H8.05c

Gene

SPBC26H8.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Manganese 1By similarity
    Metal bindingi55 – 551Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi81 – 811Manganese 2By similarity
    Metal bindingi113 – 1131Manganese 2By similarity
    Active sitei114 – 1141Proton donorBy similarity
    Metal bindingi163 – 1631Manganese 2By similarity
    Metal bindingi237 – 2371Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of DNA damage checkpoint Source: PomBase
    2. protein dephosphorylation Source: PomBase
    3. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative serine/threonine-protein phosphatase C26H8.05c (EC:3.1.3.16)
    Gene namesi
    ORF Names:SPBC26H8.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC26H8.05c.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase
    3. protein phosphatase 4 complex Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Putative serine/threonine-protein phosphatase C26H8.05cPRO_0000310805Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721Phosphoserine1 Publication
    Modified residuei348 – 3481Leucine methyl esterBy similarity

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiO74789.

    Interactioni

    Protein-protein interaction databases

    BioGridi277205. 40 interactions.
    MINTiMINT-4680772.
    STRINGi4896.SPBC26H8.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO74789.
    SMRiO74789. Positions 5-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172696.
    KOiK15423.
    OMAiVFNHRND.
    OrthoDBiEOG7FFN29.
    PhylomeDBiO74789.

    Family and domain databases

    Gene3Di3.60.21.10. 2 hits.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 2 hits.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74789-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDLDLDWQL EELENGRLIP ESNVVELCQR VRDILIEESN IQWISSPVTI    50
    CGDIHGQLHD LLELFRIGGS CPGTKYLFLG DFVDRGFYSV ETFLLLLTLK 100
    CKYPKEMTLI RGNHESRQIT QVYGFYDECV RKYGSANVWR YCCEIFDYLS 150
    LGALVDGKVF CVHGGLSPSI SSIDQIRLLD RKQEVPHEGA MCDLLWSDPE 200
    DISGWGLSPR GAGFLFGADV SEVFNRANDL SFIARAHQLV MEGYKIHFSD 250
    KDKQYPKFTN EEDSELDSDS ASPVDDSPAP GDIITIPEKD KGSVVTVWSA 300
    PNYCYRCGNV ASILQLDENQ TQSFKIFGTA SQERSGIPTK RPIADYFL 348
    Length:348
    Mass (Da):39,215
    Last modified:November 1, 1998 - v1
    Checksum:i231850C214F6E2F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21097.1.
    PIRiT40017.
    RefSeqiNP_596646.1. NM_001022568.2.

    Genome annotation databases

    EnsemblFungiiSPBC26H8.05c.1; SPBC26H8.05c.1:pep; SPBC26H8.05c.
    GeneIDi2540680.
    KEGGispo:SPBC26H8.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21097.1 .
    PIRi T40017.
    RefSeqi NP_596646.1. NM_001022568.2.

    3D structure databases

    ProteinModelPortali O74789.
    SMRi O74789. Positions 5-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277205. 40 interactions.
    MINTi MINT-4680772.
    STRINGi 4896.SPBC26H8.05c-1.

    Proteomic databases

    MaxQBi O74789.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC26H8.05c.1 ; SPBC26H8.05c.1:pep ; SPBC26H8.05c .
    GeneIDi 2540680.
    KEGGi spo:SPBC26H8.05c.

    Organism-specific databases

    PomBasei SPBC26H8.05c.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172696.
    KOi K15423.
    OMAi VFNHRND.
    OrthoDBi EOG7FFN29.
    PhylomeDBi O74789.

    Miscellaneous databases

    NextBioi 20801804.
    PROi O74789.

    Family and domain databases

    Gene3Di 3.60.21.10. 2 hits.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 2 hits.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-272, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiYOU5_SCHPO
    AccessioniPrimary (citable) accession number: O74789
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3