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Protein

Putative serine/threonine-protein phosphatase C26H8.05c

Gene

SPBC26H8.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Manganese 1By similarity1
Metal bindingi55Manganese 1By similarity1
Metal bindingi81Manganese 1By similarity1
Metal bindingi81Manganese 2By similarity1
Metal bindingi113Manganese 2By similarity1
Active sitei114Proton donorBy similarity1
Metal bindingi163Manganese 2By similarity1
Metal bindingi237Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase C26H8.05c (EC:3.1.3.16)
Gene namesi
ORF Names:SPBC26H8.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC26H8.05c
PomBaseiSPBC26H8.05c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108051 – 348Putative serine/threonine-protein phosphatase C26H8.05cAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272Phosphoserine1 Publication1
Modified residuei348Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO74789
PaxDbiO74789
PRIDEiO74789

PTM databases

iPTMnetiO74789

Interactioni

Protein-protein interaction databases

BioGridi277205, 43 interactors
STRINGi4896.SPBC26H8.05c.1

Structurei

3D structure databases

ProteinModelPortaliO74789
SMRiO74789
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696
InParanoidiO74789
KOiK15423
OMAiPDRMTLI
OrthoDBiEOG092C2R40
PhylomeDBiO74789

Family and domain databases

InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

O74789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLDLDWQL EELENGRLIP ESNVVELCQR VRDILIEESN IQWISSPVTI
60 70 80 90 100
CGDIHGQLHD LLELFRIGGS CPGTKYLFLG DFVDRGFYSV ETFLLLLTLK
110 120 130 140 150
CKYPKEMTLI RGNHESRQIT QVYGFYDECV RKYGSANVWR YCCEIFDYLS
160 170 180 190 200
LGALVDGKVF CVHGGLSPSI SSIDQIRLLD RKQEVPHEGA MCDLLWSDPE
210 220 230 240 250
DISGWGLSPR GAGFLFGADV SEVFNRANDL SFIARAHQLV MEGYKIHFSD
260 270 280 290 300
KDKQYPKFTN EEDSELDSDS ASPVDDSPAP GDIITIPEKD KGSVVTVWSA
310 320 330 340
PNYCYRCGNV ASILQLDENQ TQSFKIFGTA SQERSGIPTK RPIADYFL
Length:348
Mass (Da):39,215
Last modified:November 1, 1998 - v1
Checksum:i231850C214F6E2F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21097.1
PIRiT40017
RefSeqiNP_596646.1, NM_001022568.2

Genome annotation databases

EnsemblFungiiSPBC26H8.05c.1; SPBC26H8.05c.1:pep; SPBC26H8.05c
GeneIDi2540680
KEGGispo:SPBC26H8.05c

Similar proteinsi

Entry informationi

Entry nameiYOU5_SCHPO
AccessioniPrimary (citable) accession number: O74789
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health