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Protein

Putative serine/threonine-protein phosphatase C26H8.05c

Gene

SPBC26H8.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Manganese 1By similarity1
Metal bindingi55Manganese 1By similarity1
Metal bindingi81Manganese 1By similarity1
Metal bindingi81Manganese 2By similarity1
Metal bindingi113Manganese 2By similarity1
Active sitei114Proton donorBy similarity1
Metal bindingi163Manganese 2By similarity1
Metal bindingi237Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase C26H8.05c (EC:3.1.3.16)
Gene namesi
ORF Names:SPBC26H8.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC26H8.05c.
PomBaseiSPBC26H8.05c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • protein phosphatase 4 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108051 – 348Putative serine/threonine-protein phosphatase C26H8.05cAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272Phosphoserine1 Publication1
Modified residuei348Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO74789.
PRIDEiO74789.

PTM databases

iPTMnetiO74789.

Interactioni

Protein-protein interaction databases

BioGridi277205. 40 interactors.
MINTiMINT-4680772.

Structurei

3D structure databases

ProteinModelPortaliO74789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiO74789.
KOiK15423.
OMAiDVEIEVC.
OrthoDBiEOG092C2R40.
PhylomeDBiO74789.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLDLDWQL EELENGRLIP ESNVVELCQR VRDILIEESN IQWISSPVTI
60 70 80 90 100
CGDIHGQLHD LLELFRIGGS CPGTKYLFLG DFVDRGFYSV ETFLLLLTLK
110 120 130 140 150
CKYPKEMTLI RGNHESRQIT QVYGFYDECV RKYGSANVWR YCCEIFDYLS
160 170 180 190 200
LGALVDGKVF CVHGGLSPSI SSIDQIRLLD RKQEVPHEGA MCDLLWSDPE
210 220 230 240 250
DISGWGLSPR GAGFLFGADV SEVFNRANDL SFIARAHQLV MEGYKIHFSD
260 270 280 290 300
KDKQYPKFTN EEDSELDSDS ASPVDDSPAP GDIITIPEKD KGSVVTVWSA
310 320 330 340
PNYCYRCGNV ASILQLDENQ TQSFKIFGTA SQERSGIPTK RPIADYFL
Length:348
Mass (Da):39,215
Last modified:November 1, 1998 - v1
Checksum:i231850C214F6E2F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21097.1.
PIRiT40017.
RefSeqiNP_596646.1. NM_001022568.2.

Genome annotation databases

EnsemblFungiiSPBC26H8.05c.1; SPBC26H8.05c.1:pep; SPBC26H8.05c.
GeneIDi2540680.
KEGGispo:SPBC26H8.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21097.1.
PIRiT40017.
RefSeqiNP_596646.1. NM_001022568.2.

3D structure databases

ProteinModelPortaliO74789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277205. 40 interactors.
MINTiMINT-4680772.

PTM databases

iPTMnetiO74789.

Proteomic databases

MaxQBiO74789.
PRIDEiO74789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC26H8.05c.1; SPBC26H8.05c.1:pep; SPBC26H8.05c.
GeneIDi2540680.
KEGGispo:SPBC26H8.05c.

Organism-specific databases

EuPathDBiFungiDB:SPBC26H8.05c.
PomBaseiSPBC26H8.05c.

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiO74789.
KOiK15423.
OMAiDVEIEVC.
OrthoDBiEOG092C2R40.
PhylomeDBiO74789.

Miscellaneous databases

PROiO74789.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYOU5_SCHPO
AccessioniPrimary (citable) accession number: O74789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.