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O74789

- YOU5_SCHPO

UniProt

O74789 - YOU5_SCHPO

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Protein
Putative serine/threonine-protein phosphatase C26H8.05c
Gene
SPBC26H8.05c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Manganese 1 By similarity
Metal bindingi55 – 551Manganese 1 By similarity
Metal bindingi81 – 811Manganese 1 By similarity
Metal bindingi81 – 811Manganese 2 By similarity
Metal bindingi113 – 1131Manganese 2 By similarity
Active sitei114 – 1141Proton donor By similarity
Metal bindingi163 – 1631Manganese 2 By similarity
Metal bindingi237 – 2371Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase C26H8.05c (EC:3.1.3.16)
Gene namesi
ORF Names:SPBC26H8.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC26H8.05c.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Putative serine/threonine-protein phosphatase C26H8.05c
PRO_0000310805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721Phosphoserine1 Publication
Modified residuei348 – 3481Leucine methyl ester By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO74789.

Interactioni

Protein-protein interaction databases

BioGridi277205. 40 interactions.
MINTiMINT-4680772.
STRINGi4896.SPBC26H8.05c-1.

Structurei

3D structure databases

ProteinModelPortaliO74789.
SMRiO74789. Positions 5-347.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
KOiK15423.
OMAiVFNHRND.
OrthoDBiEOG7FFN29.
PhylomeDBiO74789.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74789-1 [UniParc]FASTAAdd to Basket

« Hide

MTDLDLDWQL EELENGRLIP ESNVVELCQR VRDILIEESN IQWISSPVTI    50
CGDIHGQLHD LLELFRIGGS CPGTKYLFLG DFVDRGFYSV ETFLLLLTLK 100
CKYPKEMTLI RGNHESRQIT QVYGFYDECV RKYGSANVWR YCCEIFDYLS 150
LGALVDGKVF CVHGGLSPSI SSIDQIRLLD RKQEVPHEGA MCDLLWSDPE 200
DISGWGLSPR GAGFLFGADV SEVFNRANDL SFIARAHQLV MEGYKIHFSD 250
KDKQYPKFTN EEDSELDSDS ASPVDDSPAP GDIITIPEKD KGSVVTVWSA 300
PNYCYRCGNV ASILQLDENQ TQSFKIFGTA SQERSGIPTK RPIADYFL 348
Length:348
Mass (Da):39,215
Last modified:November 1, 1998 - v1
Checksum:i231850C214F6E2F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21097.1.
PIRiT40017.
RefSeqiNP_596646.1. NM_001022568.2.

Genome annotation databases

EnsemblFungiiSPBC26H8.05c.1; SPBC26H8.05c.1:pep; SPBC26H8.05c.
GeneIDi2540680.
KEGGispo:SPBC26H8.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21097.1 .
PIRi T40017.
RefSeqi NP_596646.1. NM_001022568.2.

3D structure databases

ProteinModelPortali O74789.
SMRi O74789. Positions 5-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277205. 40 interactions.
MINTi MINT-4680772.
STRINGi 4896.SPBC26H8.05c-1.

Proteomic databases

MaxQBi O74789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC26H8.05c.1 ; SPBC26H8.05c.1:pep ; SPBC26H8.05c .
GeneIDi 2540680.
KEGGi spo:SPBC26H8.05c.

Organism-specific databases

PomBasei SPBC26H8.05c.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
KOi K15423.
OMAi VFNHRND.
OrthoDBi EOG7FFN29.
PhylomeDBi O74789.

Miscellaneous databases

NextBioi 20801804.
PROi O74789.

Family and domain databases

Gene3Di 3.60.21.10. 2 hits.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 2 hits.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-272, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiYOU5_SCHPO
AccessioniPrimary (citable) accession number: O74789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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