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Protein

BTB/POZ domain-containing protein 2

Gene

btb2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 2
Gene namesi
Name:btb2
ORF Names:SPBC25B2.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25B2.06c.
PomBaseiSPBC25B2.06c. btb2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • ubiquitin ligase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002783581 – 284BTB/POZ domain-containing protein 2Add BLAST284

Proteomic databases

MaxQBiO74778.
PRIDEiO74778.

Interactioni

Subunit structurei

Interacts with cul3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cul3Q097602EBI-3648173,EBI-3647930

Protein-protein interaction databases

BioGridi277073. 15 interactors.
IntActiO74778. 2 interactors.
MINTiMINT-4680701.

Structurei

3D structure databases

ProteinModelPortaliO74778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 108BTBPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO74778.
OrthoDBiEOG092C407L.
PhylomeDBiO74778.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMNSSTEIS QEPSIMKPVS SISSFVFNAG FLQGTFSDTT LIIKGETYHL
60 70 80 90 100
HALFLGRSPV LLQKLIENNP KGDVHYTIEV ETEDPYVTKE SCLFVLSTLY
110 120 130 140 150
CDSPRIPAEV NVCSVLAVSD LLGLDTLAFE ASSLIEKSIR PETMESVIRF
160 170 180 190 200
LDPNFEGLER LKMGMYPRFT SGLFNKAIQV MYNTLVSNWN TEYARLLCNL
210 220 230 240 250
PFEVIKDLLE SDKLTVGASS MARYKLANEI VKMRASFRKQ NHIEGKGDES
260 270 280
VVLAFDEGSR GIQLVHIAPG AESRRKIWKA TSVR
Length:284
Mass (Da):31,776
Last modified:November 1, 1998 - v1
Checksum:iDE50CC8EACBF0AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21264.1.
PIRiT39982.
RefSeqiNP_596074.1. NM_001021986.2.

Genome annotation databases

EnsemblFungiiSPBC25B2.06c.1; SPBC25B2.06c.1:pep; SPBC25B2.06c.
GeneIDi2540546.
KEGGispo:SPBC25B2.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21264.1.
PIRiT39982.
RefSeqiNP_596074.1. NM_001021986.2.

3D structure databases

ProteinModelPortaliO74778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277073. 15 interactors.
IntActiO74778. 2 interactors.
MINTiMINT-4680701.

Proteomic databases

MaxQBiO74778.
PRIDEiO74778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC25B2.06c.1; SPBC25B2.06c.1:pep; SPBC25B2.06c.
GeneIDi2540546.
KEGGispo:SPBC25B2.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC25B2.06c.
PomBaseiSPBC25B2.06c. btb2.

Phylogenomic databases

InParanoidiO74778.
OrthoDBiEOG092C407L.
PhylomeDBiO74778.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiO74778.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTB2_SCHPO
AccessioniPrimary (citable) accession number: O74778
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.