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Protein

Elongation factor 1 alpha-like protein

Gene

hbs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi184 – 191GTPBy similarity8
Nucleotide bindingi261 – 265GTPBy similarity5
Nucleotide bindingi323 – 326GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis, Translation regulation
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-429958. mRNA decay by 3' to 5' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1 alpha-like protein
Gene namesi
Name:hbs1By similarity
ORF Names:SPBC25B2.01, SPBC2G5.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25B2.01.
PomBaseiSPBC25B2.01. hbs1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • Dom34-Hbs1 complex Source: PomBase
  • intracellular Source: GO_Central

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260881 – 592Elongation factor 1 alpha-like proteinAdd BLAST592

Proteomic databases

MaxQBiO74774.
PRIDEiO74774.

Interactioni

Protein-protein interaction databases

BioGridi276958. 22 interactors.
DIPiDIP-59037N.
STRINGi4896.SPBC25B2.01.1.

Structurei

Secondary structure

1592
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi168 – 171Combined sources4
Beta strandi177 – 183Combined sources7
Beta strandi186 – 188Combined sources3
Helixi190 – 202Combined sources13
Beta strandi261 – 271Combined sources11
Beta strandi284 – 290Combined sources7
Helixi303 – 312Combined sources10
Beta strandi318 – 323Combined sources6
Helixi325 – 328Combined sources4
Helixi332 – 346Combined sources15
Turni347 – 349Combined sources3
Helixi354 – 356Combined sources3
Beta strandi357 – 362Combined sources6
Beta strandi364 – 366Combined sources3
Beta strandi368 – 370Combined sources3
Helixi377 – 380Combined sources4
Helixi387 – 392Combined sources6
Turni400 – 402Combined sources3
Beta strandi406 – 415Combined sources10
Beta strandi418 – 431Combined sources14
Beta strandi435 – 438Combined sources4
Turni439 – 442Combined sources4
Beta strandi443 – 451Combined sources9
Beta strandi453 – 455Combined sources3
Beta strandi460 – 462Combined sources3
Beta strandi466 – 474Combined sources9
Helixi476 – 478Combined sources3
Beta strandi484 – 486Combined sources3
Beta strandi488 – 490Combined sources3
Beta strandi493 – 504Combined sources12
Beta strandi515 – 520Combined sources6
Beta strandi525 – 538Combined sources14
Beta strandi541 – 543Combined sources3
Beta strandi548 – 558Combined sources11
Beta strandi560 – 562Combined sources3
Turni565 – 567Combined sources3
Helixi569 – 572Combined sources4
Beta strandi573 – 592Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MCAX-ray2.74A1-592[»]
ProteinModelPortaliO74774.
SMRiO74774.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO74774.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 401tr-type GPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 191G1PROSITE-ProRule annotation8
Regioni240 – 244G2PROSITE-ProRule annotation5
Regioni261 – 264G3PROSITE-ProRule annotation4
Regioni323 – 326G4PROSITE-ProRule annotation4
Regioni363 – 365G5PROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000229291.
InParanoidiO74774.
OrthoDBiEOG092C2HV8.
PhylomeDBiO74774.

Family and domain databases

InterProiView protein in InterPro
IPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
PfamiView protein in Pfam
PF00009. GTP_EFTU. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51722. G_TR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O74774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRHRDVKNL DLDDYELDEE PGEEELTEEQ EEEFRSAVAT VRETLLGVPI
60 70 80 90 100
SEKEIADTVW YYYFDVEKSV NYLLQKASSK AGAKEKQNTD SQKEKKQNKS
110 120 130 140 150
KEALADAKDP LDESSNGIKN LSLNKNDEPA FQTNGEVKMK NSSESDNQPE
160 170 180 190 200
KKKIKKQNPT DLVSVPEIFE QSNPKPVVHL VVTGHVDSGK STMLGRIMFE
210 220 230 240 250
LGEINSRSMQ KLHNEAANSG KGSFSYAWLL DTTEEERARG VTMDVASTTF
260 270 280 290 300
ESDKKIYEIG DAPGHRDFIS GMIAGASSAD FAVLVVDSSQ NNFERGFLEN
310 320 330 340 350
GQTREHAYLL RALGISEIVV SVNKLDLMSW SEDRFQEIKN IVSDFLIKMV
360 370 380 390 400
GFKTSNVHFV PISAISGTNL IQKDSSDLYK WYKGPTLLSA LDQLVPPEKP
410 420 430 440 450
YRKPLRLSID DVYRSPRSVT VTGRVEAGNV QVNQVLYDVS SQEDAYVKNV
460 470 480 490 500
IRNSDPSSTW AVAGDTVTLQ LADIEVNQLR PGDILSNYEN PVRRVRSFVA
510 520 530 540 550
EIQTFDIHGP ILSGSTLVLH LGRTVTSVSL KIVTVNNKRS RHIASRKRAL
560 570 580 590
VRISFLDGLF PLCLAEECPA LGRFILRRSG DTVAAGIVKE LC
Length:592
Mass (Da):66,016
Last modified:August 21, 2007 - v4
Checksum:i44BE2B324C97B455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21259.2.
RefSeqiXP_001713137.1. XM_001713085.2.

Genome annotation databases

EnsemblFungiiSPBC25B2.01.1; SPBC25B2.01.1:pep; SPBC25B2.01.
GeneIDi2540430.
KEGGispo:SPBC25B2.01.

Similar proteinsi

Entry informationi

Entry nameiHBS1_SCHPO
AccessioniPrimary (citable) accession number: O74774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: July 5, 2017
This is version 118 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families