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Protein

Probable delta-1-pyrroline-5-carboxylate dehydrogenase

Gene

SPBC24C6.04

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate from L-proline.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable delta-1-pyrroline-5-carboxylate dehydrogenase (SPBC24C6.04)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei193Transition state stabilizerBy similarity1
Active sitei298Proton acceptorPROSITE-ProRule annotation1
Active sitei332NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processProline metabolism
LigandNAD

Enzyme and pathway databases

ReactomeiR-SPO-389661 Glyoxylate metabolism and glycine degradation
R-SPO-70688 Proline catabolism
UniPathwayiUPA00261; UER00374

Names & Taxonomyi

Protein namesi
Recommended name:
Probable delta-1-pyrroline-5-carboxylate dehydrogenase (EC:1.2.1.88)
Short name:
P5C dehydrogenase
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenase
Gene namesi
ORF Names:SPBC24C6.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC24C6.04
PomBaseiSPBC24C6.04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565021 – 548Probable delta-1-pyrroline-5-carboxylate dehydrogenaseAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei391Phosphoserine1 Publication1
Modified residuei394Phosphoserine1 Publication1
Modified residuei396Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74766
PaxDbiO74766
PRIDEiO74766

PTM databases

iPTMnetiO74766

Interactioni

Protein-protein interaction databases

BioGridi276915, 19 interactors
STRINGi4896.SPBC24C6.04.1

Structurei

3D structure databases

ProteinModelPortaliO74766
SMRiO74766
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000271511
InParanoidiO74766
KOiK00294
OMAiPHYVLRW
OrthoDBiEOG092C19IG
PhylomeDBiO74766

Family and domain databases

CDDicd07123 ALDH_F4-17_P5CDH, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR005931 P5CDH/ALDH4A1
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01236 D1pyr5carbox1, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

O74766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFAEFKLP AIKNEPPKHY GPNSADREGI VKAYKELEAE LPVTIPVIID
60 70 80 90 100
GKEVETNTIG EQRCPFEHKK VVARYHRAGA KHVEDAIEAA LRGKKVWESL
110 120 130 140 150
PFADRSAIFL KAAHLISTKY RYKLMAATMI GQGKNIWQAE IDAGMEIIDF
160 170 180 190 200
LRFNTKYASE LYASQPPENT PGVWNRMEYR PLEGFVYAIT PFNFTAIAGN
210 220 230 240 250
LAAAPLLMGN VVLMKPSDHA VLSSYIVYQI FREAGLPAGA LQFIPGDAVE
260 270 280 290 300
VSKVCFNHPE FAGLHFTGST AVFRSLWGTI GENVANGKYR TYPKIVGETG
310 320 330 340 350
GKNFHLVHSS AEIKSAVVNA VRAAFEYQGQ KCSALSRLYV SKYAWENGFR
360 370 380 390 400
DELTKQVKSL KVGAPLTDFA NFVGPVIHQA SFNKLKKVLE SAASDSEIEV
410 420 430 440 450
LAGGKADDSE GFFVEPTVLL SKNPKHDIFV NELFGPVLSV YVYEDDNLDA
460 470 480 490 500
VCDLIDTTTP YGLTGSIFAQ DRVVVRKLTD RLRNAAGNFY INDKCTGAVV
510 520 530 540
GEQPFGGARA SGTNDKAGSG MILSRFVSPR SIKDTFAYAD SVLYPSNF
Length:548
Mass (Da):60,219
Last modified:November 1, 1998 - v1
Checksum:iE14D37E32A0B4B6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210N → K in BAA13891 (PubMed:9501991).Curated1
Sequence conflicti264L → F in BAA13891 (PubMed:9501991).Curated1
Sequence conflicti273 – 274FR → IC in BAA13891 (PubMed:9501991).Curated2
Sequence conflicti294K → N in BAA13891 (PubMed:9501991).Curated1
Sequence conflicti502E → G in BAA13891 (PubMed:9501991).Curated1
Sequence conflicti516K → E in BAA13891 (PubMed:9501991).Curated1
Sequence conflicti526F → Y in BAA13891 (PubMed:9501991).Curated1
Sequence conflicti531S → Y in BAA13891 (PubMed:9501991).Curated1
Sequence conflicti536F → L in BAA13891 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21148.1
D89230 mRNA Translation: BAA13891.1
PIRiT39968
RefSeqiNP_595958.1, NM_001021867.2

Genome annotation databases

EnsemblFungiiSPBC24C6.04.1; SPBC24C6.04.1:pep; SPBC24C6.04
KEGGispo:SPBC24C6.04

Similar proteinsi

Entry informationi

Entry nameiPUT2_SCHPO
AccessioniPrimary (citable) accession number: O74766
Secondary accession number(s): P78880
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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