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Protein

Probable proline--tRNA ligase, mitochondrial

Gene

SPBC24C6.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline--tRNA ligase, mitochondrial (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
ORF Names:SPBC24C6.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC24C6.03.
PomBaseiSPBC24C6.03.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000314630? – 425Probable proline--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO74765.
PRIDEiO74765.

Interactioni

Protein-protein interaction databases

MINTiMINT-1214056.

Structurei

3D structure databases

ProteinModelPortaliO74765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076894.
InParanoidiO74765.
KOiK01881.
OMAiLMSPTHE.
OrthoDBiEOG092C1X8M.
PhylomeDBiO74765.

Family and domain databases

CDDicd00779. ProRS_core_prok. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004500. Pro-tRNA-synth_IIa_bac-type.
IPR033730. ProRS_core_prok.
[Graphical view]
PANTHERiPTHR11451:SF3. PTHR11451:SF3. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQHLRNRAS IEVLGKAIRK YNVPESANQL LIDMGFIQPS MPGIFQYLPL
60 70 80 90 100
GLRVQNKICD LLHISMRSLG ASAISLAHLS SKEIWEKSGR WQKTGSELFR
110 120 130 140 150
LHDRNDREMC LAPTHEEDVT RTMATIIDSQ KQLPIRVYQI GRKFRDELRP
160 170 180 190 200
RGGLLRGREF MMKDLYTFDI DKASAMKTYE DVLQAYHTFF KEVGLPFVMV
210 220 230 240 250
KAATGNIGGN LSHEFHYRHP VGEDVIYTCP SCHYSTNSEM LDLSKTSSDI
260 270 280 290 300
SCPNCNDQLT STTAIEVGHA FYLGKIYSSK FNATVEVKNK QEVLHMGCYG
310 320 330 340 350
IGVSRLIAAV AHVTKDAKGL VWPSSIAPWK VLVVPTSDNH IQSAETVYDA
360 370 380 390 400
TANVVGFDNV LLEDRQNRAF GYKMRDAELI GYPFVIVVGS RFQEEGICEI
410 420
IVRSSGERYK LDKDSLHQVL LGNFL
Length:425
Mass (Da):47,932
Last modified:November 1, 1998 - v1
Checksum:iB833CA619C00E4E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21147.1.
PIRiT39967.
RefSeqiNP_595957.1. NM_001021866.2.

Genome annotation databases

EnsemblFungiiSPBC24C6.03.1; SPBC24C6.03.1:pep; SPBC24C6.03.
GeneIDi2540642.
KEGGispo:SPBC24C6.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21147.1.
PIRiT39967.
RefSeqiNP_595957.1. NM_001021866.2.

3D structure databases

ProteinModelPortaliO74765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1214056.

Proteomic databases

MaxQBiO74765.
PRIDEiO74765.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC24C6.03.1; SPBC24C6.03.1:pep; SPBC24C6.03.
GeneIDi2540642.
KEGGispo:SPBC24C6.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC24C6.03.
PomBaseiSPBC24C6.03.

Phylogenomic databases

HOGENOMiHOG000076894.
InParanoidiO74765.
KOiK01881.
OMAiLMSPTHE.
OrthoDBiEOG092C1X8M.
PhylomeDBiO74765.

Miscellaneous databases

PROiO74765.

Family and domain databases

CDDicd00779. ProRS_core_prok. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004500. Pro-tRNA-synth_IIa_bac-type.
IPR033730. ProRS_core_prok.
[Graphical view]
PANTHERiPTHR11451:SF3. PTHR11451:SF3. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYPM_SCHPO
AccessioniPrimary (citable) accession number: O74765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.