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Protein

26S proteasome regulatory subunit rpn2

Gene

rpn2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-6798695 Neutrophil degranulation
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit rpn2
Gene namesi
Name:rpn2
ORF Names:SPBC17D11.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC17D11.07c
PomBaseiSPBC17D11.07c rpn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738071 – 96526S proteasome regulatory subunit rpn2Add BLAST965

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei952Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74762
PaxDbiO74762
PRIDEiO74762

PTM databases

iPTMnetiO74762
SwissPalmiO74762

Interactioni

Protein-protein interaction databases

BioGridi276724, 10 interactors
IntActiO74762, 2 interactors
STRINGi4896.SPBC17D11.07c.1

Structurei

3D structure databases

ProteinModelPortaliO74762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati385 – 418PC 1Add BLAST34
Repeati424 – 457PC 2Add BLAST34
Repeati459 – 493PC 3Add BLAST35
Repeati494 – 528PC 4Add BLAST35
Repeati530 – 563PC 5Add BLAST34
Repeati564 – 599PC 6Add BLAST36
Repeati600 – 632PC 7Add BLAST33
Repeati634 – 668PC 8Add BLAST35
Repeati669 – 699PC 9Add BLAST31
Repeati712 – 744PC 10Add BLAST33

Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000189403
InParanoidiO74762
KOiK03032
OMAiRNCTIGL
OrthoDBiEOG092C0PBV
PhylomeDBiO74762

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR016642 26S_Psome_Rpn2
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002015 Proteasome/cyclosome_rpt
IPR035266 PSMD1
PANTHERiPTHR10943:SF2 PTHR10943:SF2, 1 hit
PfamiView protein in Pfam
PF01851 PC_rep, 3 hits
PIRSFiPIRSF015947 26S_Psome_Rpn2, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

O74762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMVYSDNTS IITSAGGLMA LLDEQERELQ VHALLKIYEF IDQLWPEISD
60 70 80 90 100
DVTKIEVMYE DHSFPERELA ALVVSKVYYY LGEYDEALLF ALSSGPKFLH
110 120 130 140 150
DKNSDYKETL IFKCIDMFIH KSAELYKNPK ADPLDERLSG VVEGIFQKCY
160 170 180 190 200
AKNEWRHVLG IAIEAHRLDI IEYILNADKE TDLKPYVLEL AMTVVLDIEF
210 220 230 240 250
RNRLLRLLLS SFLTETEPDY FSVGKCVVHL NDASVAAKLL MKLSSQNDDK
260 270 280 290 300
SLLTAYQLAF DLEDSAPQEF LNSVMDLLPS PSVANSEEDA NADSKKEDSS
310 320 330 340 350
PCGYIIRILS GEQTVKYDRE FLYAHNNTDM LILNRTKDSL EARNSVFHNA
360 370 380 390 400
VTFANAFMNF GTSSDSFFRD NLSWLSKANN WSKFTATAAL GVIHRGYYNQ
410 420 430 440 450
AMNILRPYLP EEDAPSSSTY SEGGAFYAMG LIHANHGRGV TEYLREQLKH
460 470 480 490 500
TEDEIVQYGL LLGIGLTGMA SRDETLYESV KTILFNDNAV AGSAAGISMG
510 520 530 540 550
LIMLGTASSA AIDEMLQYAH ETQHEKIIRG LGIGIALIVY GRQQEADGII
560 570 580 590 600
KELNNDLDPT LRYAGMFATA LAYCGTSNSK IVRDVLHISV SDVNDDVRRA
610 620 630 640 650
AVCALGFICF KDPNALISTV ELLVDSYNPH VRYGSAIALG IACANSGSNA
660 670 680 690 700
ALDLLSRLVE DATDFVRQGA MIAQAMILTQ HNDQLNSKVS GIRKHFEQVI
710 720 730 740 750
NEKHEDALAK LGATLAQGII DAGGRNVTIA LQTATGSLKL SAIVGLTVFL
760 770 780 790 800
QYWYWFPLTH FMSLSFSPTA LIGLDKNLNA PKFSFISNVR PKLFAYPPKS
810 820 830 840 850
VQPTAKTVQK VETAVLSTTV KAQARAKRAE REKASKGSND DEMKIDKKTT
860 870 880 890 900
EEKEATPMEM DEEKSQDISI NGNSKKEEPK SETLENFTRV VPAQLPYISF
910 920 930 940 950
NLNGRYYPVR KFTGGVLMLI DRESDKAPDL IELNRDAVPA SADTEPGEQE
960
ASPPEDFEYP FDDDD
Length:965
Mass (Da):107,276
Last modified:November 1, 1998 - v1
Checksum:iE8D1758722127F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21078.1
PIRiT39718
RefSeqiNP_596381.1, NM_001022302.2

Genome annotation databases

EnsemblFungiiSPBC17D11.07c.1; SPBC17D11.07c.1:pep; SPBC17D11.07c
GeneIDi2540191
KEGGispo:SPBC17D11.07c

Similar proteinsi

Entry informationi

Entry nameiRPN2_SCHPO
AccessioniPrimary (citable) accession number: O74762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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