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Protein

26S proteasome regulatory subunit rpn2

Gene

rpn2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit rpn2
Gene namesi
Name:rpn2
ORF Names:SPBC17D11.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC17D11.07c.
PomBaseiSPBC17D11.07c. rpn2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • proteasome regulatory particle, base subcomplex Source: PomBase
  • proteasome storage granule Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 96596526S proteasome regulatory subunit rpn2PRO_0000173807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei952 – 9521Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74762.
PRIDEiO74762.

PTM databases

iPTMnetiO74762.
SwissPalmiO74762.

Interactioni

Protein-protein interaction databases

BioGridi276724. 10 interactions.
IntActiO74762. 2 interactions.
MINTiMINT-4680555.

Structurei

3D structure databases

ProteinModelPortaliO74762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati385 – 41834PC 1Add
BLAST
Repeati424 – 45734PC 2Add
BLAST
Repeati459 – 49335PC 3Add
BLAST
Repeati494 – 52835PC 4Add
BLAST
Repeati530 – 56334PC 5Add
BLAST
Repeati564 – 59936PC 6Add
BLAST
Repeati600 – 63233PC 7Add
BLAST
Repeati634 – 66835PC 8Add
BLAST
Repeati669 – 69931PC 9Add
BLAST
Repeati712 – 74433PC 10Add
BLAST

Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated
Contains 10 PC repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000189403.
InParanoidiO74762.
KOiK03032.
OMAiSKIYFHL.
OrthoDBiEOG092C0PBV.
PhylomeDBiO74762.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR016642. 26S_Psome_Rpn2.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
[Graphical view]
PfamiPF01851. PC_rep. 3 hits.
[Graphical view]
PIRSFiPIRSF015947. 26S_Psome_Rpn2. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

O74762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMVYSDNTS IITSAGGLMA LLDEQERELQ VHALLKIYEF IDQLWPEISD
60 70 80 90 100
DVTKIEVMYE DHSFPERELA ALVVSKVYYY LGEYDEALLF ALSSGPKFLH
110 120 130 140 150
DKNSDYKETL IFKCIDMFIH KSAELYKNPK ADPLDERLSG VVEGIFQKCY
160 170 180 190 200
AKNEWRHVLG IAIEAHRLDI IEYILNADKE TDLKPYVLEL AMTVVLDIEF
210 220 230 240 250
RNRLLRLLLS SFLTETEPDY FSVGKCVVHL NDASVAAKLL MKLSSQNDDK
260 270 280 290 300
SLLTAYQLAF DLEDSAPQEF LNSVMDLLPS PSVANSEEDA NADSKKEDSS
310 320 330 340 350
PCGYIIRILS GEQTVKYDRE FLYAHNNTDM LILNRTKDSL EARNSVFHNA
360 370 380 390 400
VTFANAFMNF GTSSDSFFRD NLSWLSKANN WSKFTATAAL GVIHRGYYNQ
410 420 430 440 450
AMNILRPYLP EEDAPSSSTY SEGGAFYAMG LIHANHGRGV TEYLREQLKH
460 470 480 490 500
TEDEIVQYGL LLGIGLTGMA SRDETLYESV KTILFNDNAV AGSAAGISMG
510 520 530 540 550
LIMLGTASSA AIDEMLQYAH ETQHEKIIRG LGIGIALIVY GRQQEADGII
560 570 580 590 600
KELNNDLDPT LRYAGMFATA LAYCGTSNSK IVRDVLHISV SDVNDDVRRA
610 620 630 640 650
AVCALGFICF KDPNALISTV ELLVDSYNPH VRYGSAIALG IACANSGSNA
660 670 680 690 700
ALDLLSRLVE DATDFVRQGA MIAQAMILTQ HNDQLNSKVS GIRKHFEQVI
710 720 730 740 750
NEKHEDALAK LGATLAQGII DAGGRNVTIA LQTATGSLKL SAIVGLTVFL
760 770 780 790 800
QYWYWFPLTH FMSLSFSPTA LIGLDKNLNA PKFSFISNVR PKLFAYPPKS
810 820 830 840 850
VQPTAKTVQK VETAVLSTTV KAQARAKRAE REKASKGSND DEMKIDKKTT
860 870 880 890 900
EEKEATPMEM DEEKSQDISI NGNSKKEEPK SETLENFTRV VPAQLPYISF
910 920 930 940 950
NLNGRYYPVR KFTGGVLMLI DRESDKAPDL IELNRDAVPA SADTEPGEQE
960
ASPPEDFEYP FDDDD
Length:965
Mass (Da):107,276
Last modified:November 1, 1998 - v1
Checksum:iE8D1758722127F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21078.1.
PIRiT39718.
RefSeqiNP_596381.1. NM_001022302.2.

Genome annotation databases

EnsemblFungiiSPBC17D11.07c.1; SPBC17D11.07c.1:pep; SPBC17D11.07c.
GeneIDi2540191.
KEGGispo:SPBC17D11.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21078.1.
PIRiT39718.
RefSeqiNP_596381.1. NM_001022302.2.

3D structure databases

ProteinModelPortaliO74762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276724. 10 interactions.
IntActiO74762. 2 interactions.
MINTiMINT-4680555.

PTM databases

iPTMnetiO74762.
SwissPalmiO74762.

Proteomic databases

MaxQBiO74762.
PRIDEiO74762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC17D11.07c.1; SPBC17D11.07c.1:pep; SPBC17D11.07c.
GeneIDi2540191.
KEGGispo:SPBC17D11.07c.

Organism-specific databases

EuPathDBiFungiDB:SPBC17D11.07c.
PomBaseiSPBC17D11.07c. rpn2.

Phylogenomic databases

HOGENOMiHOG000189403.
InParanoidiO74762.
KOiK03032.
OMAiSKIYFHL.
OrthoDBiEOG092C0PBV.
PhylomeDBiO74762.

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO74762.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR016642. 26S_Psome_Rpn2.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
[Graphical view]
PfamiPF01851. PC_rep. 3 hits.
[Graphical view]
PIRSFiPIRSF015947. 26S_Psome_Rpn2. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRPN2_SCHPO
AccessioniPrimary (citable) accession number: O74762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.