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O74756 (CHS2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chitin synthase-like protein 2
Gene names
Name:chs2
ORF Names:SPBC1709.01, SPBC1734.17
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in septum formation. Has no chitin synthase activity. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein. Note: Septum. Ref.2 Ref.3 Ref.4

Sequence similarities

Belongs to the chitin synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 926926Chitin synthase-like protein 2
PRO_0000193717

Regions

Transmembrane564 – 58421Helical; Potential
Transmembrane599 – 61921Helical; Potential
Transmembrane641 – 66121Helical; Potential
Transmembrane671 – 69121Helical; Potential
Transmembrane721 – 74121Helical; Potential
Transmembrane853 – 87321Helical; Potential
Transmembrane885 – 90521Helical; Potential

Experimental info

Sequence conflict734 – 7374CMDP → VWIL in BAA87271. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O74756 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 7B880751AD53115E

FASTA926105,579
        10         20         30         40         50         60 
MSFQNPSYIN AKHRSFLQPK DTQDSQDLRN WVSHSSVDEE TAYSSSTLSS SSSKSFPCYD 

        70         80         90        100        110        120 
EYDEIKSPDD QKVEYMKTLR TLEEDAFSYT DSVYDFEERS FDEHEPPIPP LHKTGVFSVP 

       130        140        150        160        170        180 
LQPTHTVNSN SDDGYENSSK NEYLDFNSEI SASPVNEPMT HSQSYTSIDR LNSSSSHYSK 

       190        200        210        220        230        240 
DVPLLCGSLT IDCPTPIDLR GMLGPFMQKN PDEASFLRYS AITCQPEDMN NNGLQLRTWS 

       250        260        270        280        290        300 
TGRDIQIAVC LTLSDEDLAS FAISLSSIMN NLKHLCSRSK SRVWGNESWE KVLVCVVIDG 

       310        320        330        340        350        360 
RNTVHQNVLD LLASIGVYQP HIAKGRVNGK RTLSHMYEFT STINVDEKLN LTTATGDGNV 

       370        380        390        400        410        420 
PMQMLLCVKD RRLGTYNSHR WFLNGIASLA RPKVCLFVRN GARLGPTSIY HAWKAFDVDS 

       430        440        450        460        470        480 
TIGGMCGKTS IDTGKFGFRL LNPFIASQHF DQMIHNNLRL PYDSCMGYIS NALNAIYGFR 

       490        500        510        520        530        540 
YVALQDSYPN PGPLADYFEQ DQYEIPRRGI LQSNAFLAQE QLLFWKVITR KDAKWHLQYV 

       550        560        570        580        590        600 
PEACATIEAP NSMAGILESK KSEINSSFSL AVYVIVDFFS LWTTRHKFFR FLLLTVQSLV 

       610        620        630        640        650        660 
FAIEKLVNFF SMANFFLAFY FVCNATSYSS LNPYGNWARP LFLVFEYILI CLIFSQFMLA 

       670        680        690        700        710        720 
MGNRPRSCRV LLFISTALFS IIMIYFVFCV FYISLIPLHN SDNSEIVLGN NYFTTLIFSS 

       730        740        750        760        770        780 
LLILACYAFV SLICMDPFFI FTCIVQYILL MPTRIYTEQI YALCHLDDAS ISKDDNQQEF 

       790        800        810        820        830        840 
NFDTGITHCS MNDEGYTTIS IPKANVLNSV YNSSLKNFSS SNDTSVYHDV QDHCYRKPQS 

       850        860        870        880        890        900 
YEDHYQDIRT RYVLVWAVSN LILAIVLIQV FDGMRFINNG YMKYIFWSIV AFTAWKTMGA 

       910        920 
VTFIATKIIS RIANCVKSKL YIFNDP

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 720-925, SUBCELLULAR LOCATION.
Strain: ATCC 38364 / 968.
[3]"In Schizosaccharomyces pombe chs2p has no chitin synthase activity but is related to septum formation."
Martin-Garcia R., Duran A., Valdivieso M.H.
FEBS Lett. 549:176-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Chr4, a Schizosaccharomyces pombe homologue of the Saccharomyces cerevisiae Chs4p/Skt5p protein, is related to septum formation and is required for the proper localization of Chs2."
Matsuo Y., Matsuura Y., Tanaka K., Matsuda H., Kawamukai M.
Yeast 21:1005-1019(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAA21311.1.
AB027967 Genomic DNA. Translation: BAA87271.1.
PIRT39629.
T39664.
RefSeqNP_595434.1. NM_001021342.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPBC1709.01-1.

Protein family/group databases

CAZyGT2. Glycosyltransferase Family 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1709.01.1; SPBC1709.01.1:pep; SPBC1709.01.
GeneID2540176.
KEGGspo:SPBC1709.01.

Organism-specific databases

PomBaseSPBC1709.01.

Phylogenomic databases

eggNOGCOG1215.
OMADDHRRAP.
OrthoDBEOG4QNR66.

Family and domain databases

InterProIPR004834. Chitin_synth.
IPR013616. Chitin_synth_N.
[Graphical view]
PfamPF01644. Chitin_synth_1. 1 hit.
PF08407. Chitin_synth_1N. 1 hit.
[Graphical view]
ProDomPD002998. Chitin_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio20801308.

Entry information

Entry nameCHS2_SCHPO
AccessionPrimary (citable) accession number: O74756
Secondary accession number(s): Q9US88
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents