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Protein

ATP synthase subunit gamma, mitochondrial

Gene

atp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha3beta3. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit gamma, mitochondrial
Alternative name(s):
F-ATPase gamma subunit
Gene namesi
Name:atp3
ORF Names:SPBC1734.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.13.
PomBaseiSPBC1734.13. atp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000002690? – 301ATP synthase subunit gamma, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO74754.
PRIDEiO74754.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4680463.

Structurei

3D structure databases

ProteinModelPortaliO74754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase gamma chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000215911.
InParanoidiO74754.
KOiK02136.
OMAiKCKAQLS.
OrthoDBiEOG092C3WLT.
PhylomeDBiO74754.

Family and domain databases

CDDicd12151. F1-ATPase_gamma. 1 hit.
InterProiIPR000131. ATP_synth_F1_gsu.
IPR023632. ATP_synth_F1_gsu_CS.
[Graphical view]
PANTHERiPTHR11693. PTHR11693. 1 hit.
PfamiPF00231. ATP-synt. 1 hit.
[Graphical view]
PRINTSiPR00126. ATPASEGAMMA.
SUPFAMiSSF52943. SSF52943. 1 hit.
TIGRFAMsiTIGR01146. ATPsyn_F1gamma. 1 hit.
PROSITEiPS00153. ATPASE_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQTLTQAS RMRPCISVVG FRGFHASSPC EATLKEIEQR LKSIKNIEKI
60 70 80 90 100
TKTIKTVAQT KLTRAQRAME ASNKYYRVSD EVFKEAGTKA PEEGKTLMVA
110 120 130 140 150
CSSDKGLCGG IHSSISRLIR RELHDPKTFE NTSLCILGEK VRTQLLRFCP
160 170 180 190 200
ESFYLTFAHI GGASPSFEEA LQISSNILEH AKDYDRIVLV YNKFASAVSF
210 220 230 240 250
ETVMKNLYTT KAINESPNLS AYEVSDEVHQ PLMEFAFANA IFSAMAEAHC
260 270 280 290 300
SEMSSRRNAM ENASKSAGDM INKFSIQYNR QRQASITNEL IDIVTGANSL

A
Length:301
Mass (Da):33,577
Last modified:November 1, 1998 - v1
Checksum:i8595039B8E2F2B32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21307.1.
AB027877 Genomic DNA. Translation: BAA87181.1.
PIRiT39660.
RefSeqiNP_595430.1. NM_001021338.2.

Genome annotation databases

EnsemblFungiiSPBC1734.13.1; SPBC1734.13.1:pep; SPBC1734.13.
GeneIDi2539839.
KEGGispo:SPBC1734.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21307.1.
AB027877 Genomic DNA. Translation: BAA87181.1.
PIRiT39660.
RefSeqiNP_595430.1. NM_001021338.2.

3D structure databases

ProteinModelPortaliO74754.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4680463.

Proteomic databases

MaxQBiO74754.
PRIDEiO74754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1734.13.1; SPBC1734.13.1:pep; SPBC1734.13.
GeneIDi2539839.
KEGGispo:SPBC1734.13.

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.13.
PomBaseiSPBC1734.13. atp3.

Phylogenomic databases

HOGENOMiHOG000215911.
InParanoidiO74754.
KOiK02136.
OMAiKCKAQLS.
OrthoDBiEOG092C3WLT.
PhylomeDBiO74754.

Miscellaneous databases

PROiO74754.

Family and domain databases

CDDicd12151. F1-ATPase_gamma. 1 hit.
InterProiIPR000131. ATP_synth_F1_gsu.
IPR023632. ATP_synth_F1_gsu_CS.
[Graphical view]
PANTHERiPTHR11693. PTHR11693. 1 hit.
PfamiPF00231. ATP-synt. 1 hit.
[Graphical view]
PRINTSiPR00126. ATPASEGAMMA.
SUPFAMiSSF52943. SSF52943. 1 hit.
TIGRFAMsiTIGR01146. ATPsyn_F1gamma. 1 hit.
PROSITEiPS00153. ATPASE_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPG_SCHPO
AccessioniPrimary (citable) accession number: O74754
Secondary accession number(s): Q9USC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.