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Protein

Mitochondrial protein import protein mas5

Gene

mas5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Probably involved in mitochondrial protein import (By similarity). Plays a role in microtubule cytoskeleton organization.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110Substrate; via amide nitrogenBy similarity1
Metal bindingi137Zinc 1By similarity1
Metal bindingi140Zinc 1By similarity1
Metal bindingi153Zinc 2By similarity1
Metal bindingi156Zinc 2By similarity1
Metal bindingi179Zinc 2By similarity1
Metal bindingi182Zinc 2By similarity1
Metal bindingi195Zinc 1By similarity1
Metal bindingi198Zinc 1By similarity1
Sitei329Involved in dimerizationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri124 – 207CR-typeAdd BLAST84

GO - Molecular functioni

GO - Biological processi

  • microtubule cytoskeleton organization Source: PomBase
  • negative regulation of cellular response to heat Source: PomBase
  • protein folding Source: InterPro
  • protein transport Source: UniProtKB-KW
  • response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial protein import protein mas5
Gene namesi
Name:mas5
ORF Names:SPBC1734.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.11.
PomBaseiSPBC1734.11. mas5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141071 – 404Mitochondrial protein import protein mas5Add BLAST404
PropeptideiPRO_0000396683405 – 407Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei404Cysteine methyl esterBy similarity1
Lipidationi404S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO74752.
PRIDEiO74752.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi276226. 5 interactors.
IntActiO74752. 1 interactor.
MINTiMINT-4680451.

Structurei

3D structure databases

ProteinModelPortaliO74752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 68JAdd BLAST63
Repeati137 – 144CXXCXGXG motif8
Repeati153 – 160CXXCXGXG motif8
Repeati179 – 186CXXCXGXG motif8
Repeati195 – 202CXXCXGXG motif8

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 131Substrate bindingBy similarity3
Regioni209 – 210Substrate bindingBy similarity2
Regioni241 – 243Substrate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 107Gly-richAdd BLAST40

Sequence similaritiesi

Contains 1 CR-type zinc finger.Curated
Contains 1 J domain.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri124 – 207CR-typeAdd BLAST84

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000226718.
InParanoidiO74752.
KOiK09503.
OMAiETIRDED.
OrthoDBiEOG092C1UGR.
PhylomeDBiO74752.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ. 1 hit.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKETKLYEV LNVDVTASQA ELKKAYRKLA LKYHPDKNPN AGDKFKEISR
60 70 80 90 100
AYEILADEEK RATYDRFGEE GLQGGGADGG MSADDLFASF FGGGMFGGGM
110 120 130 140 150
PRGPRKGKDL VHTIKVTLED LYRGKTTKLA LQKKVICPKC SGRGGKEGSV
160 170 180 190 200
KSCASCNGSG VKFITRAMGP MIQRMQMTCP DCNGAGETIR DEDRCKECDG
210 220 230 240 250
AKVISQRKIL TVHVEKGMHN GQKIVFKEEG EQAPGIIPGD VIFVIDQKEH
260 270 280 290 300
PRFKRSGDHL FYEAHVDLLT ALAGGQIVVE HLDDRWLTIP IIPGECIRPN
310 320 330 340 350
ELKVLPGQGM LSQRHHQPGN LYIRFHVDFP EPNFATPEQL ALLEKALPPR
360 370 380 390 400
KIESAPKNAH TEECVLATVD PTEKVRIDNN VDPTTATSMD EDEDEEGGHP

GVQCAQQ
Length:407
Mass (Da):44,821
Last modified:November 1, 1998 - v1
Checksum:i3A76A614B7369426
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21305.1.
PIRiT39658.
RefSeqiNP_595428.1. NM_001021336.2.

Genome annotation databases

EnsemblFungiiSPBC1734.11.1; SPBC1734.11.1:pep; SPBC1734.11.
GeneIDi2539671.
KEGGispo:SPBC1734.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21305.1.
PIRiT39658.
RefSeqiNP_595428.1. NM_001021336.2.

3D structure databases

ProteinModelPortaliO74752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276226. 5 interactors.
IntActiO74752. 1 interactor.
MINTiMINT-4680451.

Proteomic databases

MaxQBiO74752.
PRIDEiO74752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1734.11.1; SPBC1734.11.1:pep; SPBC1734.11.
GeneIDi2539671.
KEGGispo:SPBC1734.11.

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.11.
PomBaseiSPBC1734.11. mas5.

Phylogenomic databases

HOGENOMiHOG000226718.
InParanoidiO74752.
KOiK09503.
OMAiETIRDED.
OrthoDBiEOG092C1UGR.
PhylomeDBiO74752.

Miscellaneous databases

PROiO74752.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ. 1 hit.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAS5_SCHPO
AccessioniPrimary (citable) accession number: O74752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.