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Protein

Mitochondrial protein import protein mas5

Gene

mas5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Probably involved in mitochondrial protein import (By similarity). Plays a role in microtubule cytoskeleton organization.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Substrate; via amide nitrogenBy similarity
Metal bindingi137 – 1371Zinc 1By similarity
Metal bindingi140 – 1401Zinc 1By similarity
Metal bindingi153 – 1531Zinc 2By similarity
Metal bindingi156 – 1561Zinc 2By similarity
Metal bindingi179 – 1791Zinc 2By similarity
Metal bindingi182 – 1821Zinc 2By similarity
Metal bindingi195 – 1951Zinc 1By similarity
Metal bindingi198 – 1981Zinc 1By similarity
Sitei329 – 3291Involved in dimerizationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri124 – 20784CR-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • microtubule cytoskeleton organization Source: PomBase
  • negative regulation of cellular response to heat Source: PomBase
  • protein folding Source: InterPro
  • protein transport Source: UniProtKB-KW
  • response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial protein import protein mas5
Gene namesi
Name:mas5
ORF Names:SPBC1734.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.11.
PomBaseiSPBC1734.11. mas5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Mitochondrial protein import protein mas5PRO_0000314107Add
BLAST
Propeptidei405 – 4073Removed in mature formBy similarityPRO_0000396683

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei404 – 4041Cysteine methyl esterBy similarity
Lipidationi404 – 4041S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO74752.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276226. 5 interactions.
IntActiO74752. 1 interaction.
MINTiMINT-4680451.

Structurei

3D structure databases

ProteinModelPortaliO74752.
SMRiO74752. Positions 3-68, 104-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6863JAdd
BLAST
Repeati137 – 1448CXXCXGXG motif
Repeati153 – 1608CXXCXGXG motif
Repeati179 – 1868CXXCXGXG motif
Repeati195 – 2028CXXCXGXG motif

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1313Substrate bindingBy similarity
Regioni209 – 2102Substrate bindingBy similarity
Regioni241 – 2433Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 10740Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 CR-type zinc finger.Curated
Contains 1 J domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri124 – 20784CR-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000226718.
InParanoidiO74752.
KOiK09503.
OMAiETIRDED.
OrthoDBiEOG77M90H.
PhylomeDBiO74752.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKETKLYEV LNVDVTASQA ELKKAYRKLA LKYHPDKNPN AGDKFKEISR
60 70 80 90 100
AYEILADEEK RATYDRFGEE GLQGGGADGG MSADDLFASF FGGGMFGGGM
110 120 130 140 150
PRGPRKGKDL VHTIKVTLED LYRGKTTKLA LQKKVICPKC SGRGGKEGSV
160 170 180 190 200
KSCASCNGSG VKFITRAMGP MIQRMQMTCP DCNGAGETIR DEDRCKECDG
210 220 230 240 250
AKVISQRKIL TVHVEKGMHN GQKIVFKEEG EQAPGIIPGD VIFVIDQKEH
260 270 280 290 300
PRFKRSGDHL FYEAHVDLLT ALAGGQIVVE HLDDRWLTIP IIPGECIRPN
310 320 330 340 350
ELKVLPGQGM LSQRHHQPGN LYIRFHVDFP EPNFATPEQL ALLEKALPPR
360 370 380 390 400
KIESAPKNAH TEECVLATVD PTEKVRIDNN VDPTTATSMD EDEDEEGGHP

GVQCAQQ
Length:407
Mass (Da):44,821
Last modified:November 1, 1998 - v1
Checksum:i3A76A614B7369426
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21305.1.
PIRiT39658.
RefSeqiNP_595428.1. NM_001021336.2.

Genome annotation databases

EnsemblFungiiSPBC1734.11.1; SPBC1734.11.1:pep; SPBC1734.11.
GeneIDi2539671.
KEGGispo:SPBC1734.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21305.1.
PIRiT39658.
RefSeqiNP_595428.1. NM_001021336.2.

3D structure databases

ProteinModelPortaliO74752.
SMRiO74752. Positions 3-68, 104-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276226. 5 interactions.
IntActiO74752. 1 interaction.
MINTiMINT-4680451.

Proteomic databases

MaxQBiO74752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1734.11.1; SPBC1734.11.1:pep; SPBC1734.11.
GeneIDi2539671.
KEGGispo:SPBC1734.11.

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.11.
PomBaseiSPBC1734.11. mas5.

Phylogenomic databases

HOGENOMiHOG000226718.
InParanoidiO74752.
KOiK09503.
OMAiETIRDED.
OrthoDBiEOG77M90H.
PhylomeDBiO74752.

Miscellaneous databases

PROiO74752.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast."
    Pardo M., Nurse P.
    J. Cell Sci. 118:1705-1714(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAS5_SCHPO
AccessioniPrimary (citable) accession number: O74752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.