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Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

GO - Biological processi

  • ascospore-type prospore assembly Source: PomBase
  • late endosome to vacuole transport Source: PomBase
  • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-5689880. Ub-specific processing proteases.
R-SPO-5689901. Metalloprotease DUBs.

Names & Taxonomyi

Protein namesi
Recommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene namesi
Name:hse1
ORF Names:SPBC1734.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.08.
PomBaseiSPBC1734.08. hse1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • endosome Source: PomBase
  • endosome membrane Source: UniProtKB-SubCell
  • ESCRT-0 complex Source: PomBase
  • Golgi apparatus Source: PomBase
  • nucleus Source: PomBase
  • prospore membrane Source: PomBase
  • vacuolar membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002925031 – 373Class E vacuolar protein-sorting machinery protein hse1Add BLAST373

Proteomic databases

MaxQBiO74749.
PRIDEiO74749.

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of hse1 and sst4.By similarity

Protein-protein interaction databases

MINTiMINT-4680421.

Structurei

3D structure databases

ProteinModelPortaliO74749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 146VHSPROSITE-ProRule annotationAdd BLAST131
Domaini164 – 183UIMPROSITE-ProRule annotationAdd BLAST20
Domaini215 – 274SH3PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the STAM family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 UIM (ubiquitin-interacting motif) domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

InParanoidiO74749.
KOiK04705.
OMAiEFENDPT.
OrthoDBiEOG092C454D.
PhylomeDBiO74749.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGKPNSIE TLILQATDEK NTKEKWDVIM DACDQLSSTS GDVGRNSIKF
60 70 80 90 100
LNKRLDTANA NIQLLALTLT DAIVKNCKTS IVREISSRTF TDSLLKIASD
110 120 130 140 150
STTHNRVRSR IAVLVNEWAE IMKKDPNMSL MQDICEKIRK LDIVDLRAPK
160 170 180 190 200
KPEKEAMNEL ELKREEEELQ YALALSLSES TAQSNKVENP QSTKDEPLQK
210 220 230 240 250
TNQRQESNLA TSPASTVSRV RALYDFAATE QGELSFKKGD IILVLESVYK
260 270 280 290 300
DWWKGSCKNA VGIFPVNYVQ RVVEPTIEQQ RQSAHMEQQV FDALPQIDEL
310 320 330 340 350
LDTLSTTSPD AADDDALQGK YHAMIALRPK LVRLIEKYAS QKEELMDLNE
360 370
RLLVARRDYE KLYEQSMSEM RNF
Length:373
Mass (Da):42,497
Last modified:November 1, 1998 - v1
Checksum:i378F982DBE5E0E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21302.1.
PIRiT39655.
RefSeqiNP_595425.1. NM_001021333.2.

Genome annotation databases

EnsemblFungiiSPBC1734.08.1; SPBC1734.08.1:pep; SPBC1734.08.
GeneIDi2540055.
KEGGispo:SPBC1734.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21302.1.
PIRiT39655.
RefSeqiNP_595425.1. NM_001021333.2.

3D structure databases

ProteinModelPortaliO74749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4680421.

Proteomic databases

MaxQBiO74749.
PRIDEiO74749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1734.08.1; SPBC1734.08.1:pep; SPBC1734.08.
GeneIDi2540055.
KEGGispo:SPBC1734.08.

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.08.
PomBaseiSPBC1734.08. hse1.

Phylogenomic databases

InParanoidiO74749.
KOiK04705.
OMAiEFENDPT.
OrthoDBiEOG092C454D.
PhylomeDBiO74749.

Enzyme and pathway databases

ReactomeiR-SPO-5689880. Ub-specific processing proteases.
R-SPO-5689901. Metalloprotease DUBs.

Miscellaneous databases

PROiO74749.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSE1_SCHPO
AccessioniPrimary (citable) accession number: O74749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.