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Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

GO - Biological processi

  • ascospore-type prospore assembly Source: PomBase
  • late endosome to vacuole transport Source: PomBase
  • protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: PomBase

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-5689901. Metalloprotease DUBs.

Names & Taxonomyi

Protein namesi
Recommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene namesi
Name:hse1
ORF Names:SPBC1734.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.08.
PomBaseiSPBC1734.08. hse1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002925031 – 373Class E vacuolar protein-sorting machinery protein hse1Add BLAST373

Proteomic databases

MaxQBiO74749.
PRIDEiO74749.

PTM databases

iPTMnetiO74749.

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of hse1 and sst4.By similarity

Protein-protein interaction databases

MINTiMINT-4680421.
STRINGi4896.SPBC1734.08.1.

Structurei

3D structure databases

ProteinModelPortaliO74749.
SMRiO74749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 146VHSPROSITE-ProRule annotationAdd BLAST131
Domaini164 – 183UIMPROSITE-ProRule annotationAdd BLAST20
Domaini215 – 274SH3PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the STAM family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

InParanoidiO74749.
KOiK04705.
OMAiMYAKLQS.
OrthoDBiEOG092C454D.
PhylomeDBiO74749.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR008942. ENTH_VHS.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.

Sequencei

Sequence statusi: Complete.

O74749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGKPNSIE TLILQATDEK NTKEKWDVIM DACDQLSSTS GDVGRNSIKF
60 70 80 90 100
LNKRLDTANA NIQLLALTLT DAIVKNCKTS IVREISSRTF TDSLLKIASD
110 120 130 140 150
STTHNRVRSR IAVLVNEWAE IMKKDPNMSL MQDICEKIRK LDIVDLRAPK
160 170 180 190 200
KPEKEAMNEL ELKREEEELQ YALALSLSES TAQSNKVENP QSTKDEPLQK
210 220 230 240 250
TNQRQESNLA TSPASTVSRV RALYDFAATE QGELSFKKGD IILVLESVYK
260 270 280 290 300
DWWKGSCKNA VGIFPVNYVQ RVVEPTIEQQ RQSAHMEQQV FDALPQIDEL
310 320 330 340 350
LDTLSTTSPD AADDDALQGK YHAMIALRPK LVRLIEKYAS QKEELMDLNE
360 370
RLLVARRDYE KLYEQSMSEM RNF
Length:373
Mass (Da):42,497
Last modified:November 1, 1998 - v1
Checksum:i378F982DBE5E0E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21302.1.
PIRiT39655.
RefSeqiNP_595425.1. NM_001021333.2.

Genome annotation databases

EnsemblFungiiSPBC1734.08.1; SPBC1734.08.1:pep; SPBC1734.08.
GeneIDi2540055.
KEGGispo:SPBC1734.08.

Similar proteinsi

Entry informationi

Entry nameiHSE1_SCHPO
AccessioniPrimary (citable) accession number: O74749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families