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Protein

Eukaryotic translation initiation factor 4E-2

Gene

tif452

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.By similarity

GO - Molecular functioni

  • RNA cap binding Source: PomBase
  • translation initiation factor activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

ReactomeiR-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-72649 Translation initiation complex formation
R-SPO-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-SPO-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E-2
Short name:
eIF-4E-2
Short name:
eIF4E-2
Alternative name(s):
eIF-4F 25 kDa subunit 2
mRNA cap-binding protein 2
Gene namesi
Name:tif452
ORF Names:SPBC1709.18, SPBC409.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1709.18
PomBaseiSPBC1709.18 tif452

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001936521 – 243Eukaryotic translation initiation factor 4E-2Add BLAST243

Proteomic databases

MaxQBiO74743
PaxDbiO74743
PRIDEiO74743

PTM databases

iPTMnetiO74743

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity).By similarity

Protein-protein interaction databases

BioGridi276416, 30 interactors
STRINGi4896.SPBC1709.18.1

Structurei

3D structure databases

ProteinModelPortaliO74743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000186751
InParanoidiO74743
KOiK03259
OMAiNKFGGRW
OrthoDBiEOG092C4INY
PhylomeDBiO74743

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit

Sequencei

Sequence statusi: Complete.

O74743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAEDSRHS KNEGFPNTSL ITEKLDLLDL FGSPKVKTER EGRPARLLEG
60 70 80 90 100
LSAVNAETAF VKTHPLQHEW TLWFLKPPTQ GLEWSDLLKE IISFKTVEEF
110 120 130 140 150
WGIFKTISKA SMLPAKSDYS YFLKGIRPEW EDPQNMNGGK WAYQSKHKGS
160 170 180 190 200
NLDELWLYMV LAAIGETLDP TGKEVTGVVC NMRKGFYRIA VWTRNCNDKD
210 220 230 240
VLEKIGLRFK EVLGISDKET IEYSAHEDSS KAGSMRAKTR MSL
Length:243
Mass (Da):27,654
Last modified:November 1, 1998 - v1
Checksum:i3CAD4E82E07D1B13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21257.1
PIRiT39646
RefSeqiNP_595451.1, NM_001021360.2

Genome annotation databases

EnsemblFungiiSPBC1709.18.1; SPBC1709.18.1:pep; SPBC1709.18
GeneIDi2539870
KEGGispo:SPBC1709.18

Similar proteinsi

Entry informationi

Entry nameiIF4E2_SCHPO
AccessioniPrimary (citable) accession number: O74743
Secondary accession number(s): Q9UUB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health