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Protein

Peptidyl-prolyl cis-trans isomerase cyp3

Gene

cyp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase cyp3 (EC:5.2.1.8)
Short name:
PPIase cyp3
Alternative name(s):
Rotamase cyp3
Gene namesi
Name:cyp3
ORF Names:SPBC1709.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1709.04c.
PomBaseiSPBC1709.04c. cyp3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • spindle pole body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Peptidyl-prolyl cis-trans isomerase cyp3PRO_0000232959Add
BLAST

Proteomic databases

MaxQBiO74729.

Interactioni

Protein-protein interaction databases

BioGridi276731. 19 interactions.
MINTiMINT-4680273.

Structurei

3D structure databases

ProteinModelPortaliO74729.
SMRiO74729. Positions 5-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 172165PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000065981.
InParanoidiO74729.
KOiK09567.
OMAiMANAGEP.
OrthoDBiEOG092C5DG5.
PhylomeDBiO74729.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEPVVFMD IAIDGRLLGR IKIRLFSSIV PKTAENFRQF CTGETLGVNQ
60 70 80 90 100
KPIGYKNSTF HRIIQGFMIQ GGDFVSGDGT GSATIFNSRT FPDENFTLKH
110 120 130 140 150
DRPGLLSMAN AGKDSNGCQF FITTVPCDFL DGKHVVFGEV IEGYDIVKEI
160 170
ESTPVGANSR PKSNVAIVEC GEM
Length:173
Mass (Da):18,906
Last modified:November 1, 1998 - v1
Checksum:i116DA3AF5FED08B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21243.1.
PIRiT39632.
RefSeqiNP_595437.1. NM_001021345.2.

Genome annotation databases

EnsemblFungiiSPBC1709.04c.1; SPBC1709.04c.1:pep; SPBC1709.04c.
GeneIDi2540198.
KEGGispo:SPBC1709.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21243.1.
PIRiT39632.
RefSeqiNP_595437.1. NM_001021345.2.

3D structure databases

ProteinModelPortaliO74729.
SMRiO74729. Positions 5-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276731. 19 interactions.
MINTiMINT-4680273.

Proteomic databases

MaxQBiO74729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1709.04c.1; SPBC1709.04c.1:pep; SPBC1709.04c.
GeneIDi2540198.
KEGGispo:SPBC1709.04c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1709.04c.
PomBaseiSPBC1709.04c. cyp3.

Phylogenomic databases

HOGENOMiHOG000065981.
InParanoidiO74729.
KOiK09567.
OMAiMANAGEP.
OrthoDBiEOG092C5DG5.
PhylomeDBiO74729.

Miscellaneous databases

PROiO74729.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIH_SCHPO
AccessioniPrimary (citable) accession number: O74729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.