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Protein

Peroxisomal targeting signal receptor

Gene

PEX5

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.By similarity

GO - Molecular functioni

GO - Biological processi

  • fatty acid beta-oxidation Source: CGD
  • fatty acid metabolic process Source: CGD
  • protein import into peroxisome matrix Source: CGD
  • protein import into peroxisome matrix, docking Source: CGD
  • protein targeting to peroxisome Source: CGD

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
Peroxin-5
Gene namesi
Name:PEX5
Ordered Locus Names:CAALFM_C400150CA
ORF Names:CaO19.13085, CaO19.5640
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Organism-specific databases

CGDiCAL0000177775. PEX5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063081 – 592Peroxisomal targeting signal receptorAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitination at Cys-10 is UBC4-independent but requires the presence of PEX4. Ubiquitination at Lys-22 is UBC4-dependent (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Thioester bond, Ubl conjugation

Proteomic databases

PRIDEiO74711.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO74711.
SMRiO74711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati295 – 329TPR 1Add BLAST35
Repeati330 – 363TPR 2Add BLAST34
Repeati440 – 473TPR 3Add BLAST34
Repeati475 – 507TPR 4Add BLAST33
Repeati509 – 541TPR 5Add BLAST33

Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

InParanoidiO74711.
KOiK13342.
OrthoDBiEOG092C1NSE.

Family and domain databases

Gene3Di1.20.960.10. 1 hit.
1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR024111. PTS1R_family.
IPR023392. Tom20_dom_sf.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom_sf.
IPR019734. TPR_repeat.
PANTHERiPTHR10130. PTHR10130. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 4 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

O74711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVGGGSEC SVNGNAVAQF NKHTQQDRSL QQQVANQHGN VAQNQGFKKD
60 70 80 90 100
NLMNVRDRAN LDQFMNNGAP QNSFQFQPMR HELNTIQNQP NAIHQQQSNW
110 120 130 140 150
SQDFVAQSPS AQITTPIAKT GSPVNAQWAS EFSQAPATQQ HNQRPGQFGP
160 170 180 190 200
RLGGYRPMMG MSMAYQSQPQ QQQQQQHNQE PQVDWENQFK EIEELTNKAE
210 220 230 240 250
EVEEIQREQS PEIVVDDKYQ ATFQEVWDSL NSESFENDFI NQQYEDFKRT
260 270 280 290 300
QKDGFPADMN QWEKDFAKYA STRAHFGDYQ FEDKQSNQFL DLPKDQDPYE
310 320 330 340 350
IGLQLMENGA KLSEAALAFE AAIQRDENHV DAWLKLGEVQ TQNEKEIAGI
360 370 380 390 400
SALEKCLELH PENSEALMNL AISYINEGYD NAAFATLERW ISTKYPQIVE
410 420 430 440 450
KARQENPTIT DEDRFSLNKR VTELFLNAAQ LSPNQASMDA DVQMGLGVLF
460 470 480 490 500
YANEEFDKTI DCFKAALSIR PDDAILWNRL GASLANSNRS EEAVDAYFKA
510 520 530 540 550
LQLKPTFVRA RYNLGVSCIN IGCYKEAAEH LLSGLSMHQV EGVDTVSTLN
560 570 580 590
HNQSTSLTET LKRAFIAMER RDLLELVKPN MDLNQFRGEF SF
Length:592
Mass (Da):67,324
Last modified:January 24, 2006 - v2
Checksum:iFA5B271F220B38E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA. Translation: AOW28808.1.
AJ003115 Genomic DNA. Translation: CAA05870.1.
RefSeqiXP_713321.1. XM_708228.2.

Genome annotation databases

EnsemblFungiiAOW28808; AOW28808; CAALFM_C400150CA.
GeneIDi3645026.
KEGGical:CAALFM_C400150CA.

Similar proteinsi

Entry informationi

Entry nameiPEX5_CANAL
AccessioniPrimary (citable) accession number: O74711
Secondary accession number(s): A0A1D8PL28, Q59UT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 24, 2006
Last modified: November 22, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families