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Protein
Submitted name:

Endoglucanase

Gene

eglA

Organism
Aspergillus niger
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradationUniRule annotation

Protein family/group databases

CAZyiGH12. Glycoside Hydrolase Family 12.
mycoCLAPiEGL12A_ASPNG.

Names & Taxonomyi

Protein namesi
Submitted name:
EndoglucanaseImported
Submitted name:
Endoglucanase AImported (EC:3.2.1.4Imported)
Gene namesi
Name:eglAImported
OrganismiAspergillus nigerImported
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 239223Sequence analysisPRO_5006963624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 48Combined sources

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00010994.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KS4X-ray2.50A17-239[»]
1KS5X-ray2.10A17-239[»]
SMRiO74705. Positions 17-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 12 (cellulase H) family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4111NZR. LUCA.

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR013319. GH11/12.
IPR002594. GH12.
[Graphical view]
PfamiPF01670. Glyco_hydro_12. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPVSLAML AATAMGQTMC SQYDSASSPP YSVNQNLWGE YQGTGSQCVY
60 70 80 90 100
VDKLSSSGAS WHTEWTWSGG EGTVKSYSNS GVTFNKKLVS DVSSIPTSVE
110 120 130 140 150
WKQDNTNVNA DVAYDLFTAA NVDHATSSGD YELMIWLARY GNIQPIGKQI
160 170 180 190 200
ATATVGGKSW EVWYGSTTQA GAEQRTYSFV SESPINSYSG DINAFFSYLT
210 220 230
QNQGFPASSQ YLINLQFGTE AFTGGPATFT VDNWTASVN
Length:239
Mass (Da):25,859
Last modified:November 1, 1998 - v1
Checksum:i5EB6267DA54A4A2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM281200 mRNA. Translation: AIX97359.1.
AJ224451 Genomic DNA. Translation: CAA11964.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM281200 mRNA. Translation: AIX97359.1.
AJ224451 Genomic DNA. Translation: CAA11964.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KS4X-ray2.50A17-239[»]
1KS5X-ray2.10A17-239[»]
SMRiO74705. Positions 17-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00010994.

Protein family/group databases

CAZyiGH12. Glycoside Hydrolase Family 12.
mycoCLAPiEGL12A_ASPNG.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4111NZR. LUCA.

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR013319. GH11/12.
IPR002594. GH12.
[Graphical view]
PfamiPF01670. Glyco_hydro_12. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional activator XlnR regulates both xylanolytic and endoglucanase gene expression in Aspergillus niger."
    van Peij N.N., Gielkens M.M., de Vries R.P., Visser J., de Graaff L.H.
    Appl. Environ. Microbiol. 64:3615-3619(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CBS 120.49Imported.
  2. Knight M.A., Drinkwater R.D.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CBS 120.49Imported.
  3. "Determination of the structure of an endoglucanase from Aspergillus niger and its mode of inhibition by palladium chloride."
    Khademi S., Zhang D., Swanson S.M., Wartenberg A., Witte K., Meyer E.F.
    Acta Crystallogr. D 58:660-667(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 17-239, DISULFIDE BONDS.
  4. "An acidothermophilic functionally active novel GH12 family endoglucanase from Aspergillus niger HO: purification, characterization and molecular interaction studies."
    Rawat R., Kumar S., Chadha B.S., Kumar D., Oberoi H.S.
    Antonie Van Leeuwenhoek 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HOImported.

Entry informationi

Entry nameiO74705_ASPNG
AccessioniPrimary (citable) accession number: O74705
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.