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Protein

Aconitate hydratase, mitochondrial

Gene

Aco

Organism
Aspergillus terreus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

Iron, Iron-sulfurUniRule annotation, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13634.

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydratase, mitochondrialUniRule annotation (EC:4.2.1.-UniRule annotation)
Short name:
AconitaseUniRule annotation
Gene namesi
Name:AcoImported
OrganismiAspergillus terreusImported
Taxonomic identifieri33178 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MitochondrionUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO74699.
SMRiO74699. Positions 28-771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 500437AconitaseInterPro annotationAdd
BLAST
Domaini581 – 708128Aconitase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR006248. Aconitase_mito-like.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01340. aconitase_mito. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALAPKSRL LLGTRGLATV ADSPLDKKVE MTNHEKGNYI NYKKMSENLD
60 70 80 90 100
IVRRRLSRPL TYAEKVLYSH LDDPHGQDIE RGVSYLKLRP DRVACQDATA
110 120 130 140 150
QMAILQFMSA GMPSVATPTT VHCDHLIEAQ VGGEKDLARA NEINKEVYDF
160 170 180 190 200
LATATAKYNI GFWKPGSGII HQIVLENYAF PGGLMIGTDS HTPNAGGLAM
210 220 230 240 250
AAIGVGGADA VDVMAGLPWE LKAPKVIGVK LTGEMSGWTT PKDIILKVAG
260 270 280 290 300
LLTVKGGTGA IIEYHGPGVN SLSCTGMGTI CNMGAEIGAT TSMFPFNDRM
310 320 330 340 350
YDYLKATKRQ HIGEFARSYA KELREDEGAE YDQLIEINLS ELEPHINGPF
360 370 380 390 400
TPDLATPISK FKEAVDANGW PEELKVGLIG SCTNSSYEDM SRAASIARDA
410 420 430 440 450
LNHGVKSKSL FTVTPGSEQI RATIERDGQL QTLEEFGGVI LANACGPCIG
460 470 480 490 500
QWDRKDVKKG EPNSIISSYN RNFTGRNDAN PATHAFVASP DLVVAMCVAG
510 520 530 540 550
TLKFNPLTDT VKDKDGKEFK LAPPSGDGLP SKGYDAGRNT YQAPPQDRAS
560 570 580 590 600
INVAVSPTSD RLQLLAGFEA WDGKDANGIP ILIKCQGKTT TDHISMAGPW
610 620 630 640 650
LKYRGHLDNI SNNMLIGAVN AENGEANKVK NKFTGEYGAV PATARDYKAR
660 670 680 690 700
GVKWVVIGDW NYGEGSSREH AALEPRHLGG LAIITRSFAR IHETNLKKQG
710 720 730 740 750
MLPLTFADPA DYDKIQPEDT VDLLCTELEV GKPMTLRVHP KNGSTFDVKL
760 770
NHTFNESQIE WFKDGSALNT MARKAASN
Length:778
Mass (Da):84,327
Last modified:November 1, 1998 - v1
Checksum:i12D38227F7709C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093142 mRNA. Translation: AAC61778.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093142 mRNA. Translation: AAC61778.1.

3D structure databases

ProteinModelPortaliO74699.
SMRiO74699. Positions 28-771.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13634.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR006248. Aconitase_mito-like.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01340. aconitase_mito. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO74699_ASPTE
AccessioniPrimary (citable) accession number: O74699
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.