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Protein

13 kDa ribonucleoprotein-associated protein

Gene

snu13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing, Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-SPO-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
13 kDa ribonucleoprotein-associated protein
Gene namesi
Name:snu13
ORF Names:SPAC607.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC607.03c.
PomBaseiSPAC607.03c. snu13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002906621 – 12513 kDa ribonucleoprotein-associated proteinAdd BLAST125

Proteomic databases

MaxQBiO74690.
PRIDEiO74690.

Interactioni

Subunit structurei

Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA (By similarity).By similarity

Protein-protein interaction databases

BioGridi279116. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliO74690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7Ae family.Curated

Phylogenomic databases

HOGENOMiHOG000055226.
InParanoidiO74690.
KOiK12845.
OMAiWPLADQK.
OrthoDBiEOG092C5PRN.
PhylomeDBiO74690.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNPKAFPL ADSGLTQQIL DLVQQASHYK QLRKGANEAT KTLNRGISEF
60 70 80 90 100
IVMAADTEPI EILLHLPLLC EDKNVPYVFV PSKAALGRAC GVSRPVISAS
110 120
ITTNEASDLL PQIQAIKLAI EKLLI
Length:125
Mass (Da):13,535
Last modified:November 1, 1998 - v1
Checksum:iAAE05D2194DAEB9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087136 Genomic DNA. Translation: AAC62085.1.
CU329670 Genomic DNA. Translation: CAB63790.1.
PIRiT50223.
RefSeqiNP_593592.1. NM_001019023.2.

Genome annotation databases

EnsemblFungiiSPAC607.03c.1; SPAC607.03c.1:pep; SPAC607.03c.
GeneIDi2542663.
KEGGispo:SPAC607.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087136 Genomic DNA. Translation: AAC62085.1.
CU329670 Genomic DNA. Translation: CAB63790.1.
PIRiT50223.
RefSeqiNP_593592.1. NM_001019023.2.

3D structure databases

ProteinModelPortaliO74690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279116. 5 interactors.

Proteomic databases

MaxQBiO74690.
PRIDEiO74690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC607.03c.1; SPAC607.03c.1:pep; SPAC607.03c.
GeneIDi2542663.
KEGGispo:SPAC607.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC607.03c.
PomBaseiSPAC607.03c. snu13.

Phylogenomic databases

HOGENOMiHOG000055226.
InParanoidiO74690.
KOiK12845.
OMAiWPLADQK.
OrthoDBiEOG092C5PRN.
PhylomeDBiO74690.

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-SPO-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiO74690.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNU13_SCHPO
AccessioniPrimary (citable) accession number: O74690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.