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Protein

13 kDa ribonucleoprotein-associated protein

Gene

snu13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing, Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-SPO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-SPO-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
13 kDa ribonucleoprotein-associated protein
Gene namesi
Name:snu13
ORF Names:SPAC607.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC607.03c
PomBaseiSPAC607.03c snu13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002906621 – 12513 kDa ribonucleoprotein-associated proteinAdd BLAST125

Proteomic databases

MaxQBiO74690
PaxDbiO74690
PRIDEiO74690

Interactioni

Subunit structurei

Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA (By similarity).By similarity

Protein-protein interaction databases

BioGridi2791165 interactors.
STRINGi4896.SPAC607.03c.1

Structurei

3D structure databases

ProteinModelPortaliO74690
SMRiO74690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000055226
InParanoidiO74690
KOiK12845
OMAiKPFYVRF
OrthoDBiEOG092C5PRN
PhylomeDBiO74690

Family and domain databases

Gene3Di3.30.1330.301 hit
InterProiView protein in InterPro
IPR002415 H/ACA_rnp_Nhp2_euk
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00883 NUCLEARHMG
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequencei

Sequence statusi: Complete.

O74690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNPKAFPL ADSGLTQQIL DLVQQASHYK QLRKGANEAT KTLNRGISEF
60 70 80 90 100
IVMAADTEPI EILLHLPLLC EDKNVPYVFV PSKAALGRAC GVSRPVISAS
110 120
ITTNEASDLL PQIQAIKLAI EKLLI
Length:125
Mass (Da):13,535
Last modified:November 1, 1998 - v1
Checksum:iAAE05D2194DAEB9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087136 Genomic DNA Translation: AAC62085.1
CU329670 Genomic DNA Translation: CAB63790.1
PIRiT50223
RefSeqiNP_593592.1, NM_001019023.2

Genome annotation databases

EnsemblFungiiSPAC607.03c.1; SPAC607.03c.1:pep; SPAC607.03c
GeneIDi2542663
KEGGispo:SPAC607.03c

Similar proteinsi

Entry informationi

Entry nameiSNU13_SCHPO
AccessioniPrimary (citable) accession number: O74690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome