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Reviewed, UniProtKB/Swiss-Prot O74685 (FADH_PICPA)

Last modified June 16, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    S-(hydroxymethyl)glutathione dehydrogenase
    EC=1.1.1.284
Alternative name(s):
    Glutathione-dependent formaldehyde dehydrogenase
      Short name=GSH-FDH
      Short name=FALDH
      Short name=FDH
      Short name=FLD
    EC=1.1.1.-
Gene names
Name: FLD1
OrganismPichia pastoris (Yeast)
Taxonomic identifier4922 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia

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Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379S-(hydroxymethyl)glutathione dehydrogenase
PRO_0000160782

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding991Zinc 2 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1131Zinc 2 By similarity
Metal binding1761Zinc 1; catalytic By similarity

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Sequences

Sequence LengthMass (Da)Tools
O74685-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: CEB8E9229A54BDE2

FASTA37940,559
        10         20         30         40         50         60 
MSTEGQIIKC KAAVAWEAGK DLSIEEIEVL PPRAHEVRVK VEFTGVCHTD AYTLSGADAE 

        70         80         90        100        110        120 
GSFPVVFGHE GAGVVESVGE GVESVKVGDS VVLLYTPECR ECKFCLSGKT NLCGKIRATQ 

       130        140        150        160        170        180 
GKGLLPDGTS RFRCKGKDLF HYMGCSSFSQ YTVVADISVV KVQDEAPKDK TCLLGCGVTT 

       190        200        210        220        230        240 
GYGAAINTAK ISKGDKIGVF GAGCIGLSVI QGAVSKGASE IIVIDINDSK KAWADQFGAT 

       250        260        270        280        290        300 
KFVNPTTLPE GTNIVDYLID ITDGGFDYTF DCTGNVQVMR NALESCHKGW GESIIIGVAA 

       310        320        330        340        350        360 
AGKEISTRPF QLVTGRVWRG CAFGGIKGRT QMPSLVQDYL DGKIKVDEFI THRHDLDNIN 

       370 
KAFHDMHAGN CIRAVITMH

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References

[1]"A strong nitrogen source-regulated promoter for controlled expression of foreign genes in the yeast Pichia pastoris."
Shen S., Sulter G., Jeffries T.W., Cregg J.M.
Gene 216:93-102(1998) [PubMed: 9714758] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: JC100.

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Cross-references

Sequence databases

AF066054 Genomic DNA. Translation: AAC35913.1.

3D structure databases

HSSPHSSP built from PDB template 1M6H based on UniProtKB P11766.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.1.1.284. 390.

Family and domain databases

InterProIPR014183. ADH_3.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameFADH_PICPA
AccessionPrimary (citable) accession number: O74685
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents