Reviewed, UniProtKB/Swiss-Prot O74657 (ALS2_CANAL)

Names and origin

Protein names

Recommended name:
    Agglutinin-like protein 2

Gene names

Name:	ALS2
ORF Names:	CaO19.1097, CaO19.8699

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	1756 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted.

General annotation (Comments)

Function	May play a role in adhesion and pathogenesis.
Post-translational modification	N-glycosylated and O-glycosylated Potential.

Ontologies

Keywords
Biological process	Cell adhesion
Domain	Repeat Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 1756	1739	Agglutinin-like protein 2		PRO_0000020692
Amino acid modifications
	Glycosylation	253	1	N-linked (GlcNAc...) Potential
	Glycosylation	315	1	N-linked (GlcNAc...) Potential
	Glycosylation	578	1	N-linked (GlcNAc...) Potential
	Glycosylation	614	1	N-linked (GlcNAc...) Potential
	Glycosylation	686	1	N-linked (GlcNAc...) Potential
	Glycosylation	866	1	N-linked (GlcNAc...) Potential
	Glycosylation	1010	1	N-linked (GlcNAc...) Potential
	Glycosylation	1154	1	N-linked (GlcNAc...) Potential
	Glycosylation	1370	1	N-linked (GlcNAc...) Potential
	Glycosylation	1406	1	N-linked (GlcNAc...) Potential
	Glycosylation	1442	1	N-linked (GlcNAc...) Potential
	Glycosylation	1514	1	N-linked (GlcNAc...) Potential
	Glycosylation	1550	1	N-linked (GlcNAc...) Potential
	Glycosylation	1586	1	N-linked (GlcNAc...) Potential
	Glycosylation	1622	1	N-linked (GlcNAc...) Potential
	Glycosylation	1658	1	N-linked (GlcNAc...) Potential
	Glycosylation	1730	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O74657-1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 10B72B1E480D5EB6	FASTA	1,756	188,008
	10 20 30 40 50 60 MLLQFLLLSL CVSVATAKVI TGVFNSFDSL TWTRAGNYAY KGPNRPTWNA VLGWSLDGTS 70 80 90 100 110 120 ANPGDTFTLN MPCVFKFITD QTSVDLTAEG VKYATCQFYS GEEFTTFSSL KCTVSNTLTS 130 140 150 160 170 180 SIKALGTVTL PISFNVGGTG SSVDLESSQC FKAGTNTVTF NDGDKKISID VDFEKTNEDA 190 200 210 220 230 240 SGYFIASRLI PSINKVSITY VAPQCANGYT SGAMGFIVLT GDTTIDCSNV HVGITKGLND 250 260 270 280 290 300 WNFPVSSDSL SYNKTCSSTG ISITYENVPA GYRPFFDVYT SVSGQNRQLR YTNDYACVGS 310 320 330 340 350 360 SLQSKPFNLR LRGYNNSEAN SNGFVIVATT RTVTDSTTAV TTLPFNPSVD KTKTIEILQP 370 380 390 400 410 420 IPTTTITTSY VGVTTSYSTK TAPIGETATV IVDVPYHTTT TVTSEWTGTI TTTTTRTNPT 430 440 450 460 470 480 DSIDTVVVQV PSPNPTVTTT EYWSQSYATT TTVTAPPGGT DSVIIREPPN PTVTTTEYWS 490 500 510 520 530 540 QSYATSSTVT APPGGTDTVI IREPPNPTVT TTEYWSQSYA TTTTVTAPPG GTDSVIIREP 550 560 570 580 590 600 PNPTVTTTEY WSQSFATTTT ITAPPGETDT VLIREPPNHT VTTTEYWSQS YVTTSTITAP 610 620 630 640 650 660 PGGTDTVIIR EPPNYTVTTT EYWSQSYATT TTVTAPPGGT DTVIIREPPN PTVTTTEYWS 670 680 690 700 710 720 QSYATTTTVT GPPGGTDTVI IREPPNQTVT TTEYWSQSYA TTTTVTAPPG GTDTVIIREP 730 740 750 760 770 780 PNPTVTTTEY WSQSYATTTT VTGPPGGTDT VIIREPPNPT VTTTEYWSQS YATTTTVTAP 790 800 810 820 830 840 PGGTATVIIR EPPNPTVTTT EYWSQSYATT TTVTGPPGGT DTVIIREPPN PTVTTTEYWS 850 860 870 880 890 900 QSYATTTTVT APPGGTATVI IREPPNYTVT TTEYWSQSYA TTTTVTGPPG GTDTVIIREP 910 920 930 940 950 960 PSPTVTTTEY WSQSYATTTT VTAPPGGTAT VIIREPPNPT VTTTEYWSQS YATTTTVTGP 970 980 990 1000 1010 1020 PGGTDTVIIR EPPNPTVTTT EYWSQSYATT TTVTAPPGGT ATVIIREPPN YTVTTTEYWS 1030 1040 1050 1060 1070 1080 QSYATTTTVT GPPGGTDTVI IREPPSPTVT TTEYWSQSYA TTTTVTAPPG GTATVIIWEP 1090 1100 1110 1120 1130 1140 PNPTVTTTEY WSQSYATTTT VTGPPGGTDT VIIREPPSPT VTTTEYWSQS YATTTTVTAP 1150 1160 1170 1180 1190 1200 PGGTATVIIR EPPNYTVTTT EYWSQSYATT TTVTGPPGGT DTVIIREPPN PTVTTTEYWS 1210 1220 1230 1240 1250 1260 QSFATTTTVT APPGGTDSVI IREPPNPTVT TTEYWSQSYA TTTTVTAPPG GTDSVIIREP 1270 1280 1290 1300 1310 1320 PNPTVTTTEY WSQSFATTTT VTAPPGGTDS VIIREPPNPT VTTTEYWSQS YATTTTVTAP 1330 1340 1350 1360 1370 1380 PGGTDSVIIR EPPNPTVTTT EYWSQSYATT TTVTAPPGGT ATVIIREPPN YTVTTTEYWS 1390 1400 1410 1420 1430 1440 QSYATTTTVT APPGGTATVI IREPPNYTVT TTEYWSQSYA TTTTITAPPG DTDTVIIREP 1450 1460 1470 1480 1490 1500 PNYTVTTTEY WSQSFATTTT VTAPPGGTDS VIIREPPNPT VTTTEYWSQS YATTTTVTAP 1510 1520 1530 1540 1550 1560 PGGTATVIIR EPPNYTVTTT EYWSQSYATT TTVTAPPGGT ATVIIREPPN YTVTTTEYWS 1570 1580 1590 1600 1610 1620 QSYATTTTIT APPGDTDTVI IREPPNYTVT TTEYWSQSYA TTTTVTAPPG GTDTVIIREP 1630 1640 1650 1660 1670 1680 PNYTVTTTEY WSQSYATTTT VTAPPGGTAT VIIREPPNYT VTTTEYWSQS YATTTTVTGP 1690 1700 1710 1720 1730 1740 PGSTDTVIIR EPPNPTVTTT EYWSQSYATT TTVTAPPGGT ATVIIREPPN YTVTTTEYWS 1750 QSYATTTTVT APPRWY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.
[2]	"Identification of Candida albicans ALS2 and ALS4 and localization of als proteins to the fungal cell surface." Hoyer L.L., Payne T.L., Hecht J.E. J. Bacteriol. 180:5334-5343(1998) [PubMed: 9765564] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-468. Strain: 1161.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000169 Genomic DNA. Translation: EAK92889.1. AACQ01000168 Genomic DNA. Translation: EAK92914.1. AF024580 Genomic DNA. Translation: AAC64235.1.
RefSeq	XP_712085.1. XP_712109.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3646295. 3646321.
KEGG	cal:CaO19.1097. cal:CaO19.8699.
Organism-specific databases
CGD	CAL0075525. ALS2.
Family and domain databases
InterPro	IPR008966. Adhesion_bac. IPR008440. Candida_ALS. [Graphical view]
Pfam	PF05792. Candida_ALS. 6 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALS2_CANAL

Accession

Primary (citable) accession number: O74657
Secondary accession number(s): Q59QW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 5, 2009
Last modified:	November 24, 2009
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)