Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionine--tRNA ligase, mitochondrial

Gene

MSM1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei332 – 3321ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.10. 1096.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligase, mitochondrial (EC:6.1.1.10)
Alternative name(s):
Methionyl-tRNA synthetase
Short name:
MetRS
Gene namesi
Name:MSM1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Methionine--tRNA ligase, mitochondrialPRO_0000139270Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO74634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi25 – 3713"HIGH" regionAdd
BLAST
Motifi329 – 3335"KMSKS" region

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProiIPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.

Sequencei

Sequence statusi: Complete.

O74634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKIRGPLI QLRYKSTKAF YITTPIFYVN AAPHIGHLYS MLIADTRNKW
60 70 80 90 100
EKLNPSKESF MLTGTDEHGL KIQSTAEKLG LEPKVLVDKV SQNFSKLAEQ
110 120 130 140 150
FDVNYDRFIR TTDNDHIELV RYFWNLMMEK GFIYTDTHSG WYSISDETFF
160 170 180 190 200
PETQIEEVVK NGKAVKISSE TKNEVVYQEE TNYFFKLSMF QEQLIQFLKQ
210 220 230 240 250
NPEFIKPKHR YQFILKELED TKLPDLSISR PSSRLKWSIE VPNDSTQKIY
260 270 280 290 300
VWFDALLNYL TATKFPHGFE VQDSKFVTPE NSIWPATHVI GKDIIRFHCI
310 320 330 340 350
YWPIFLMAAG IELPKQVIVH SHWLCDGFKM SKSLGNLVDP MEISEYYGVD
360 370 380 390 400
PVRFFLVENS NIDDDCKFSE ELLQRSRDAV LGKYCNLISR IGGKNFSIEE
410 420 430 440 450
AVKSFASGEF NNIREIIETY TINKDSVEGL LSSLNKLTTD LNDLYNQMDH
460 470 480 490 500
YFTNFDYIRA IQCWWSVINQ ANQIFQSAEP WTYVKLINSP ETPAELKEKY
510 520 530 540 550
RILNNYFVYL CAETTRISSI LIQPVMPQLS KKILDRLNVS GRTSEFTTLS
560 570
ADLQYGSGAN SKSHKVPLEK IAPRDIK
Length:577
Mass (Da):67,120
Last modified:November 1, 1998 - v1
Checksum:i129413ACD5B14728
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006140 Genomic DNA. Translation: BAA33373.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006140 Genomic DNA. Translation: BAA33373.1.

3D structure databases

ProteinModelPortaliO74634.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi6.1.1.10. 1096.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProiIPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of mitochondrial methionyl-tRNA synthetase from a pathogenic fungi Candida albicans."
    Lee S.W., Jo Y.J., Kim S.
    Gene 215:311-318(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSYMM_CANAX
AccessioniPrimary (citable) accession number: O74634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.