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Protein

Mannose-1-phosphate guanyltransferase

Gene

mpg1

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).By similarity

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.1 Publication

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanyltransferase (mpg1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCell cycle
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.13. 6451.
UniPathwayiUPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase
GTP-mannose-1-phosphate guanylyltransferase
Gene namesi
Name:mpg1
OrganismiHypocrea jecorina (Trichoderma reesei)
Taxonomic identifieri51453 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384931 – 364Mannose-1-phosphate guanyltransferaseAdd BLAST364

Structurei

3D structure databases

ProteinModelPortaliO74624.
SMRiO74624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1322. Eukaryota.
COG1208. LUCA.
OMAiYWMDVGQ.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR001451. Hexapep.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiView protein in PROSITE
PS00101. HEXAPEP_TRANSFERASES. 1 hit.

Sequencei

Sequence statusi: Complete.

O74624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLILVGGF GTRLRPLTLT LPKPLVEFCN KPMIVHQIEA LVAAGVTDIV
60 70 80 90 100
LAVNYRPEIM EKFLAEYEEK YNINIEFSVE SEPLDTAGPL KLAERILGKD
110 120 130 140 150
DSPFFVLNSD VICDYPFKEL LEFHKAHGDE GTIVVTKVEE PSKYGVVVHK
160 170 180 190 200
PNHPSRIDRF VEKPVEFVGN RINAGMYIFN PSVLKRIELR PTSIEKETFP
210 220 230 240 250
AMVADNQLHS FDLEGFWMDV GQPKDFLSGT CLYLSSLTKK GSKELTPPTE
260 270 280 290 300
PYVHGGNVMI HPSAKIGKNC RIGPNVTIGP DVVVGDGVRL QRCVLLKGSK
310 320 330 340 350
VKDHAWVKST IVGWNSTVGR WARLENVTVL GDDVTIGDEI YVNGGSVLPH
360
KSIKANVDVP AIIM
Length:364
Mass (Da):40,285
Last modified:November 1, 1998 - v1
Checksum:i66203BAF15284EBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89991 mRNA. Translation: AAC39498.1.

Similar proteinsi

Entry informationi

Entry nameiMPG1_HYPJE
AccessioniPrimary (citable) accession number: O74624
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1998
Last modified: July 5, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families