Reviewed, UniProtKB/Swiss-Prot O74624 (MPG1_TRIRE)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase
    GDP-mannose pyrophosphorylase

Gene names

Name:

mpg1

Organism

Trichoderma reesei (Hypocrea jecorina)

Taxonomic identifier

51453 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Hypocreaceae › Hypocrea

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose. Ref.1
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Mannose-1-phosphate guanyltransferase		PRO_0000238493

Sequences

	Sequence		Length	Mass (Da)
	O74624-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 66203BAF15284EBA	FASTA	364	40,285
	10 20 30 40 50 60 MKGLILVGGF GTRLRPLTLT LPKPLVEFCN KPMIVHQIEA LVAAGVTDIV LAVNYRPEIM 70 80 90 100 110 120 EKFLAEYEEK YNINIEFSVE SEPLDTAGPL KLAERILGKD DSPFFVLNSD VICDYPFKEL 130 140 150 160 170 180 LEFHKAHGDE GTIVVTKVEE PSKYGVVVHK PNHPSRIDRF VEKPVEFVGN RINAGMYIFN 190 200 210 220 230 240 PSVLKRIELR PTSIEKETFP AMVADNQLHS FDLEGFWMDV GQPKDFLSGT CLYLSSLTKK 250 260 270 280 290 300 GSKELTPPTE PYVHGGNVMI HPSAKIGKNC RIGPNVTIGP DVVVGDGVRL QRCVLLKGSK 310 320 330 340 350 360 VKDHAWVKST IVGWNSTVGR WARLENVTVL GDDVTIGDEI YVNGGSVLPH KSIKANVDVP AIIM

References

[1]

"Isolation of a Trichoderma reesei cDNA encoding GTP: alpha-D-mannose-1-phosphate guanyltransferase involved in early steps of protein glycosylation." Kruszewska J.S., Saloheimo M., Penttila M., Palamarczyk G. Curr. Genet. 33:445-450(1998) [PubMed: 9644208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY. Strain: QM9414 / Rut C-30.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U89991 mRNA. Translation: AAC39498.1.
3D structure databases
HSSP	HSSP built from PDB template 1HM0 based on UniProtKB Q97R46.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.13. 280374.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPG1_TRIRE

Accession

Primary (citable) accession number: O74624

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	November 1, 1998
Last modified:	September 22, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)