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Protein

NADH-cytochrome b5 reductase 1

Gene

cbr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity).By similarity

Catalytic activityi

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 157FADBy similarityAdd BLAST16
Nucleotide bindingi168 – 199FADBy similarityAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-cytochrome b5 reductase 1 (EC:1.6.2.2)
Alternative name(s):
Microsomal cytochrome b reductase
Gene namesi
Name:cbr1
ORF Names:SPCC970.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC970.03
PomBaseiSPCC970.03 cbr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei32 – 49HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108441 – 301NADH-cytochrome b5 reductase 1Add BLAST301

Proteomic databases

MaxQBiO74557
PaxDbiO74557
PRIDEiO74557

PTM databases

iPTMnetiO74557

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi4896.SPCC970.03.1

Structurei

3D structure databases

ProteinModelPortaliO74557
SMRiO74557
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 162FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000175005
InParanoidiO74557
KOiK00326
OMAiHNTAIYR
OrthoDBiEOG092C43G8
PhylomeDBiO74557

Family and domain databases

InterProiView protein in InterPro
IPR017927 Fd_Rdtase_FAD-bd
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR001834 NADH-Cyt_B5_reductase
IPR008333 OxRdtase_FAD-bd_dom
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00970 FAD_binding_6, 1 hit
PF00175 NAD_binding_1, 1 hit
PRINTSiPR00406 CYTB5RDTASE
PR00371 FPNCR
SUPFAMiSSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

O74557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQTLLSTP LHGVYIPVFL IIFGTYIVKR EWVGYAIVVA FSLGFHKFWR
60 70 80 90 100
GRVRKVLSDK IQQFELSDKA VLNHNTAIYR FRLPRANDVL GLPIGQHLKV
110 120 130 140 150
FVDVDGKEYS RSYTPLSSDA DKGYFDLLVK SYPNGKVSKK FSELKIGDTI
160 170 180 190 200
GVRGPKGNWK HRTGLARHFG MIAGGTGITP MLQIIRAVLS NFEDPTEITL
210 220 230 240 250
LYANVSEGDI VLRDEIDALA KKDPRFTVHY VLNNPPENWK GSVGFVTQEL
260 270 280 290 300
IKAHFPAPSP ETKVLICGPT PMVNSLREAT VALGYEKSRA ISKLEDQVFV

F
Length:301
Mass (Da):33,723
Last modified:November 1, 1998 - v1
Checksum:i455412A9AB47AA6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20696.1
PIRiT41677
RefSeqiNP_587852.1, NM_001022845.2

Genome annotation databases

EnsemblFungiiSPCC970.03.1; SPCC970.03.1:pep; SPCC970.03
GeneIDi2539526
KEGGispo:SPCC970.03

Similar proteinsi

Entry informationi

Entry nameiNCB5R_SCHPO
AccessioniPrimary (citable) accession number: O74557
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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