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Protein

Branchpoint-bridging protein

Gene

bpb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the splicing of pre-mRNA. The BPB1(SF1)-u2af59-u2af23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri309 – 326CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri334 – 351CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

  • mRNA cis splicing, via spliceosome Source: PomBase
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Branchpoint-bridging protein
Alternative name(s):
Splicing factor 1
Zinc finger protein bpb1
Gene namesi
Name:bpb1
Synonyms:bbp, sf1
ORF Names:SPCC962.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC962.06c.
PomBaseiSPCC962.06c. bpb1.

Subcellular locationi

GO - Cellular componenti

  • commitment complex Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • U2-type prespliceosome Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002561501 – 587Branchpoint-bridging proteinAdd BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Phosphoserine1 Publication1
Modified residuei133Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74555.
PRIDEiO74555.

PTM databases

iPTMnetiO74555.

Interactioni

Subunit structurei

U2AF large subunit (u2af59), U2AF small subunit (u2af23) and bpb1 interact to form a complex required for complex A formation.

Protein-protein interaction databases

BioGridi275413. 9 interactors.
MINTiMINT-4680054.

Structurei

3D structure databases

ProteinModelPortaliO74555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 271KHPROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi401 – 561Pro-richAdd BLAST161

Sequence similaritiesi

Belongs to the BBP/SF1 family.Curated
Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri309 – 326CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri334 – 351CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000197271.
InParanoidiO74555.
KOiK13095.
OMAiCKFARPG.
OrthoDBiEOG092C2J4N.
PhylomeDBiO74555.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR031150. BBP/SF1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR032570. SF1-HH.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR11208:SF45. PTHR11208:SF45. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF16275. SF1-HH. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSRSVGST GSNNTPLGRR RFDEKPDSLP PLPDANGMSN GYRDSYKSNS
60 70 80 90 100
RMDHRPDGYH DGRGRRAYRK HYWGHPTPIE EMLPSQMELE TAVKSCMTME
110 120 130 140 150
QLELYSLNVR LEEITQKLRT GDVVPHHRER SPSPPPQYDN HGRRLNTREI
160 170 180 190 200
RYKKKLEDER HRIIERAMKM VPGFRAPSDY RRPAKTQEKV YVPVKDYPEI
210 220 230 240 250
NFIGLLIGPR GHTLKDMEAK SGAKIAIRGK GSVKEGKGRS DPSVRGNMEE
260 270 280 290 300
DLHCLVTADS EDKINHAIKL IDNVIQTAAS VPEGQNDLKR NQLRQLATLN
310 320 330 340 350
GTLRDDENQV CQNCGNVGHR RFDCPERINH TMNIVCRHCG SIGHIARDCP
360 370 380 390 400
VRDQQPPMAD STADREYQSL MQELGGGSAI SNGNGEPQKS IEFSESGAAS
410 420 430 440 450
PQAGHPPPWA AASTSVSSST SSPAPWAKPA SSAAPSNPAP WQQPAAPQSA
460 470 480 490 500
PALSMNPSSL PPWQQPTQQS AVQPSNLVPS QNAPFIPGTS APLPPTTFAP
510 520 530 540 550
PGVPLPPIPG APGMPNLNMS QPPMVPPGMA LPPGMPAPFP GYPAVPAMPG
560 570 580
IPGATAPPGA PGSYNTSESS NLNAPPGVSM PNGYSNR
Length:587
Mass (Da):63,622
Last modified:November 1, 1998 - v1
Checksum:i2680FAEDF793ACF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073779 mRNA. Translation: AAF02214.1.
CU329672 Genomic DNA. Translation: CAA20438.1.
PIRiT41653.
RefSeqiNP_587871.1. NM_001022863.2.

Genome annotation databases

EnsemblFungiiSPCC962.06c.1; SPCC962.06c.1:pep; SPCC962.06c.
GeneIDi2538832.
KEGGispo:SPCC962.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073779 mRNA. Translation: AAF02214.1.
CU329672 Genomic DNA. Translation: CAA20438.1.
PIRiT41653.
RefSeqiNP_587871.1. NM_001022863.2.

3D structure databases

ProteinModelPortaliO74555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275413. 9 interactors.
MINTiMINT-4680054.

PTM databases

iPTMnetiO74555.

Proteomic databases

MaxQBiO74555.
PRIDEiO74555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC962.06c.1; SPCC962.06c.1:pep; SPCC962.06c.
GeneIDi2538832.
KEGGispo:SPCC962.06c.

Organism-specific databases

EuPathDBiFungiDB:SPCC962.06c.
PomBaseiSPCC962.06c. bpb1.

Phylogenomic databases

HOGENOMiHOG000197271.
InParanoidiO74555.
KOiK13095.
OMAiCKFARPG.
OrthoDBiEOG092C2J4N.
PhylomeDBiO74555.

Miscellaneous databases

PROiO74555.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR031150. BBP/SF1.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR032570. SF1-HH.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR11208:SF45. PTHR11208:SF45. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF16275. SF1-HH. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBBP_SCHPO
AccessioniPrimary (citable) accession number: O74555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.