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O74548 (ARGD_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable acetylornithine aminotransferase, mitochondrial
Short name=ACOAT
EC=2.6.1.11
Gene names
Name:arg1
ORF Names:SPCC777.09c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Sequence caution

The sequence BAA13776.1 differs from that shown. Reason: Frameshift at positions 223 and 285.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 441Probable acetylornithine aminotransferase, mitochondrialPRO_0000002081

Amino acid modifications

Modified residue2941N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Sequence conflict131S → A in BAA13776. Ref.1
Sequence conflict1521A → D in BAA13776. Ref.1
Sequence conflict1581K → R in BAA13776. Ref.1
Sequence conflict3031G → E in BAA13776. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O74548 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 9EC88B1AC1B9ADB3

FASTA44147,509
        10         20         30         40         50         60 
MFQRRSLLSV RSSGSQIAFR RFVSLTHKDP TPDTTSCNII KKEGANIISV YARYPVVAAK 

        70         80         90        100        110        120 
GEGSYLFDKE GRKYIDFTSG VAVTSLGHAH PEVARLAADQ CSKLVHSSNL FYNEPAIELS 

       130        140        150        160        170        180 
NVINNSLAKN SGIAGPTKIF FANCGTEANE TALKFARKAA FEKYGEGKSQ IVYFNNSFHG 

       190        200        210        220        230        240 
RSLGSLSITA NPKYKRGFQP LLPDVVQAVY NDPASIEQFV NDKTAAVIVE PVQGEGGICP 

       250        260        270        280        290        300 
AKPEFLIALR KACDKVGASL IYDEIQCGLG RSGDLWAHSI VKDVASPDII TVAKPLANGL 

       310        320        330        340        350        360 
PIGATIVSSK IAAEIHPGEH GSTFGGNPVA CRVGTFCVNE LGSSKILQNV RKQHKALTSR 

       370        380        390        400        410        420 
FDDFVAKYPN LIRGYAGRGL LLGLQFTEPP AKFIELARQQ GLLLLPGGNN NTRVLPSLNV 

       430        440 
KDEVIAKGLD IMESTLKALS K

« Hide

References

[1]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: PR745.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D89114 mRNA. Translation: BAA13776.1. Frameshift.
CU329672 Genomic DNA. Translation: CAA20713.1.
PIRT11715.
T42091.
RefSeqNP_588255.1. NM_001023245.1.

3D structure databases

ProteinModelPortalO74548.
ModBaseSearch...

Protein-protein interaction databases

STRINGO74548.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC777.09c.1; SPCC777.09c.1:pep; SPCC777.09c.
GeneID2538726.
GenomeReviewsGene locus arg1 in contig CU329672_GR.
KEGGspo:SPCC777.09c.
NMPDRfig|4896.1.peg.593.

Organism-specific databases

GeneDB_SpombeSPCC777.09c.

Phylogenomic databases

eggNOGfuNOG06187.
GeneTreeEFGT00050000003450.
HOGENOMHBG725944.
OMATTYARPN.
OrthoDBEOG4HMNJM.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-000185-MONOMER.

Gene expression databases

ArrayExpressO74548.

Family and domain databases

InterProIPR004636. AcOrn/SuccinylOrn_aminoTrfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KOK00818.
PANTHERPTHR11986. Aminotrans_3. 1 hit.
PTHR11986:SF19. ArgD_aminotrans. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR00707. ArgD. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGD_SCHPO
AccessionPrimary (citable) accession number: O74548
Secondary accession number(s): P78766
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1998
Last modified: December 14, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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