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Protein

Putative S-(hydroxymethyl)glutathione dehydrogenase 2

Gene

SPCC13B11.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi50 – 501Zinc 1; catalyticBy similarity
Metal bindingi72 – 721Zinc 1; catalyticBy similarity
Metal bindingi102 – 1021Zinc 2By similarity
Metal bindingi105 – 1051Zinc 2By similarity
Metal bindingi108 – 1081Zinc 2By similarity
Metal bindingi116 – 1161Zinc 2By similarity
Metal bindingi179 – 1791Zinc 1; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative S-(hydroxymethyl)glutathione dehydrogenase 2 (EC:1.1.1.284)
Alternative name(s):
Glutathione-dependent formaldehyde dehydrogenase 2 (EC:1.1.1.-)
Short name:
FALDH 2
Short name:
FDH 2
Short name:
FLD 2
Short name:
GSH-FDH 2
Gene namesi
ORF Names:SPCC13B11.04c, SPCC777.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC13B11.04c.
PomBaseiSPCC13B11.04c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrion Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Putative S-(hydroxymethyl)glutathione dehydrogenase 2PRO_0000160784Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-4679921.

Structurei

3D structure databases

ProteinModelPortaliO74540.
SMRiO74540. Positions 7-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294674.
InParanoidiO74540.
KOiK00121.
OMAiMITHVLK.
OrthoDBiEOG75F4PS.
PhylomeDBiO74540.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQSPTAGKI INCKAAVAWQ PAAPLSIENV QVFPPRVHEV RIKIVNSGVC
60 70 80 90 100
HTDAYTLSGK DPEGLFPVIL GHEGAGIVES VGPQVTTVQV GDPVIALYTP
110 120 130 140 150
ECKTCKFCKS GKTNLCGRIR TTQGKGLMPD GTSRFSCNGN TLLHFMGCST
160 170 180 190 200
FSEYTVVADI SVVAIERLAP LDSVCLLGCG ITTGYGAATI TADIKEGDSV
210 220 230 240 250
AVFGLGSVGL AVIQGAVKKR AGRIFGIDVN PEKKNWAMSF GATDFINPND
260 270 280 290 300
LQSPIQDVLI HETDGGLDWT FDCTGNVHVM RSALEACHKG WGQSIVIGVA
310 320 330 340 350
AAGQEISTRP FQLVTGRVWR GCAFGGVKGR SQLPDLVKEY LDHKLEIDKY
360 370 380
ITHRRPLKEI NEAFTDMHNG NCIKTVLSIP
Length:380
Mass (Da):40,712
Last modified:August 1, 1999 - v2
Checksum:i2E39F0F347BBBC45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21785.1.
PIRiT40965.
RefSeqiNP_588247.1. NM_001023237.2.

Genome annotation databases

EnsemblFungiiSPCC13B11.04c.1; SPCC13B11.04c.1:pep; SPCC13B11.04c.
GeneIDi2538802.
KEGGispo:SPCC13B11.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21785.1.
PIRiT40965.
RefSeqiNP_588247.1. NM_001023237.2.

3D structure databases

ProteinModelPortaliO74540.
SMRiO74540. Positions 7-379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4679921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC13B11.04c.1; SPCC13B11.04c.1:pep; SPCC13B11.04c.
GeneIDi2538802.
KEGGispo:SPCC13B11.04c.

Organism-specific databases

EuPathDBiFungiDB:SPCC13B11.04c.
PomBaseiSPCC13B11.04c.

Phylogenomic databases

HOGENOMiHOG000294674.
InParanoidiO74540.
KOiK00121.
OMAiMITHVLK.
OrthoDBiEOG75F4PS.
PhylomeDBiO74540.

Enzyme and pathway databases

ReactomeiR-SPO-71384. Ethanol oxidation.

Miscellaneous databases

NextBioi20799984.
PROiO74540.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiFADH2_SCHPO
AccessioniPrimary (citable) accession number: O74540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1999
Last modified: December 9, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.