ID   PROD_SCHPO              Reviewed;         492 AA.
AC   O74524;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Probable proline dehydrogenase, mitochondrial;
DE            EC=1.5.99.8;
DE   AltName: Full=Probable proline oxidase;
DE   Flags: Precursor;
GN   ORFNames=SPCC70.03c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: L-proline + acceptor = (S)-1-pyrroline-5-
CC       carboxylate + reduced acceptor.
CC   -!- COFACTOR: FAD.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
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DR   EMBL; CU329672; CAA19353.1; -; Genomic_DNA.
DR   PIR; T41549; T41549.
DR   RefSeq; NP_588537.1; -.
DR   GeneID; 2539452; -.
DR   KEGG; spo:SPCC70.03c; -.
DR   NMPDR; fig|4896.1.peg.875; -.
DR   GeneDB_Spombe; SPCC70.03c; -.
DR   OMA; O74524; RARENID.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-000435-MON; -.
DR   BRENDA; 1.5.99.8; 653.
DR   ArrayExpress; O74524; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:EC.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR   InterPro; IPR002872; Proline_DH.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914; Proline_oxidase; 1.
DR   Pfam; PF01619; Pro_dh; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase;
KW   Proline metabolism; Transit peptide.
FT   TRANSIT       1      ?       Mitochondrion (Potential).
FT   CHAIN         ?    492       Probable proline dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000025805.
SQ   SEQUENCE   492 AA;  55813 MW;  6710836E021D9D95 CRC64;
     MRAFRLASGV LRNRKVILGI GAGSLITAGN IKIRNDSKFD AFFAKGFPDE LQHRSLFSVL
     RSAFVYEICS RAWLVKLSLG AMSLCDVFHL SFLYNPFCRY TFYKHFCGGE TPQAVMATMD
     TLQAAGITSC LNYSREVDLD GDMDVNKIAS QGVVPPQVPV PSEKNQKVLR QIADKAFESN
     MHIIDMATYK PGTVCAVKLT PFINPLVLQR YNSILNQYPV ESACNYLEHL KSPELSTYEV
     SELKKFWEYA DKLCQFAKEK QIPLFIDAEQ TYFQDCMHAV TVDLMRKYNK EVAIVHNTYQ
     LYLKKSRKIM DDHIKKCVAE GWLMGAKLVR GAYLNSEPRF LIHDTKAETD KDFDSAVEAI
     IAAAAKFAPG DPASASDPIA SRKGKWGIMV ASHNKKTMFE SVNLAETKKV DFTKTSFYLA
     QLLGMADDIT YALAYSQRNQ QPNFCIVKYV SCGPISEVLP YLVRRARENI DALDRCKEER
     AYYRQALRRR IF
//