O74524 (PROD_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable proline dehydrogenase, mitochondrial
EC=1.5.99.8

Alternative name(s):
Probable proline oxidase

Gene names

ORF Names:

SPCC70.03c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate By similarity.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the proline oxidase family.

Ontologies

Keywords
Biological process	Proline metabolism
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe proline catabolic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	mitochondrial matrix Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Molecular function	proline dehydrogenase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 492		Probable proline dehydrogenase, mitochondrial		PRO_0000025805

Sequences

	Sequence		Length	Mass (Da)
	O74524 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 6710836E021D9D95	FASTA	492	55,813
	10 20 30 40 50 60 MRAFRLASGV LRNRKVILGI GAGSLITAGN IKIRNDSKFD AFFAKGFPDE LQHRSLFSVL 70 80 90 100 110 120 RSAFVYEICS RAWLVKLSLG AMSLCDVFHL SFLYNPFCRY TFYKHFCGGE TPQAVMATMD 130 140 150 160 170 180 TLQAAGITSC LNYSREVDLD GDMDVNKIAS QGVVPPQVPV PSEKNQKVLR QIADKAFESN 190 200 210 220 230 240 MHIIDMATYK PGTVCAVKLT PFINPLVLQR YNSILNQYPV ESACNYLEHL KSPELSTYEV 250 260 270 280 290 300 SELKKFWEYA DKLCQFAKEK QIPLFIDAEQ TYFQDCMHAV TVDLMRKYNK EVAIVHNTYQ 310 320 330 340 350 360 LYLKKSRKIM DDHIKKCVAE GWLMGAKLVR GAYLNSEPRF LIHDTKAETD KDFDSAVEAI 370 380 390 400 410 420 IAAAAKFAPG DPASASDPIA SRKGKWGIMV ASHNKKTMFE SVNLAETKKV DFTKTSFYLA 430 440 450 460 470 480 QLLGMADDIT YALAYSQRNQ QPNFCIVKYV SCGPISEVLP YLVRRARENI DALDRCKEER 490 AYYRQALRRR IF

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAA19353.1.
PIR	T41549.
RefSeq	NP_588537.1. NM_001023525.1.
3D structure databases
ProteinModelPortal	O74524.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC70.03c.1; SPCC70.03c.1:pep; SPCC70.03c.
GeneID	2539452.
KEGG	spo:SPCC70.03c.
NMPDR	fig|4896.1.peg.875.
Organism-specific databases
GeneDB_Spombe	SPCC70.03c.
Phylogenomic databases
eggNOG	fuNOG05623.
GeneTree	EFGT00050000002133.
OMA	CKEERAY.
OrthoDB	EOG4R53B7.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000435-MONOMER.
Gene expression databases
ArrayExpress	O74524.
Family and domain databases
InterPro	IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view]
KO	K00309.
PANTHER	PTHR13914. Proline_oxidase. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROD_SCHPO

Accession

Primary (citable) accession number: O74524

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program