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Protein

Histone chaperone cia1

Gene

cia1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chromatin assembly Source: PomBase
  • chromatin organization Source: PomBase
  • chromatin silencing Source: PomBase
  • histone acetylation Source: PomBase
  • histone exchange Source: PomBase
  • nucleosome assembly Source: InterPro
  • nucleosome disassembly Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone chaperone cia1
Alternative name(s):
Anti-silencing function protein 1
Gene namesi
Name:cia1
Synonyms:asf1
ORF Names:SPCC663.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC663.05c.
PomBaseiSPCC663.05c. cia1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897431 – 262Histone chaperone cia1Add BLAST262

Proteomic databases

MaxQBiO74515.
PRIDEiO74515.

Interactioni

Subunit structurei

Interacts with histone H3 and histone H4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276128. 72 interactors.
MINTiMINT-4679711.

Structurei

Secondary structure

1262
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Beta strandi15 – 17Combined sources3
Beta strandi22 – 30Combined sources9
Beta strandi38 – 47Combined sources10
Helixi51 – 53Combined sources3
Beta strandi54 – 62Combined sources9
Beta strandi67 – 76Combined sources10
Helixi81 – 83Combined sources3
Beta strandi84 – 86Combined sources3
Helixi87 – 90Combined sources4
Beta strandi91 – 102Combined sources12
Beta strandi105 – 118Combined sources14
Helixi123 – 125Combined sources3
Helixi128 – 131Combined sources4
Helixi138 – 140Combined sources3
Beta strandi141 – 145Combined sources5
Beta strandi151 – 154Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CU9X-ray1.80A1-161[»]
2DZEX-ray1.80A/B1-161[»]
2Z34X-ray2.40A/B1-161[»]
2Z3FX-ray2.70A/B/C/D/E/F/G/H1-161[»]
ProteinModelPortaliO74515.
SMRiO74515.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO74515.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili173 – 196Sequence analysisAdd BLAST24
Coiled coili223 – 253Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi176 – 259Glu-richAdd BLAST84

Sequence similaritiesi

Belongs to the ASF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000197425.
InParanoidiO74515.
KOiK10753.
OMAiCAYEDNE.
OrthoDBiEOG092C4LUM.
PhylomeDBiO74515.

Family and domain databases

Gene3Di2.60.40.1490. 1 hit.
InterProiIPR006818. ASF1-like.
IPR017282. Hist_deposition_Asf1.
[Graphical view]
PANTHERiPTHR12040. PTHR12040. 1 hit.
PfamiPF04729. ASF1_hist_chap. 1 hit.
[Graphical view]
PIRSFiPIRSF037759. Histone_Asf1. 1 hit.
SUPFAMiSSF101546. SSF101546. 1 hit.

Sequencei

Sequence statusi: Complete.

O74515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVNILSVN VLNNPAKFSD PYKFEITFEC LEPLKSDLEW KLTYVGSATS
60 70 80 90 100
QSYDQILDTL LVGPIPIGIN KFVFEADPPN IDLLPQLSDV LGVTVILLSC
110 120 130 140 150
AYEDNEFVRV GYYVNNEMEG LNLQEMDDAE IKKVKVDISK VWRSILAEKP
160 170 180 190 200
RVTRFNIQWD NPDFDDAPPV QPDADEEEEE EEADEMEEEF DEEGEGDEEE
210 220 230 240 250
EEEDDGDGDG EGDGDGEGEN DGKGSEEEEE EEIDIEEEEE ESALANASAA
260
EEKPEEKPET SQ
Length:262
Mass (Da):29,431
Last modified:November 1, 1998 - v1
Checksum:iFA4E491BC8B49171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031397 Genomic DNA. Translation: BAB82475.1.
CU329672 Genomic DNA. Translation: CAA20365.1.
PIRiT41536.
RefSeqiNP_588267.1. NM_001023257.2.

Genome annotation databases

EnsemblFungiiSPCC663.05c.1; SPCC663.05c.1:pep; SPCC663.05c.
GeneIDi2539568.
KEGGispo:SPCC663.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031397 Genomic DNA. Translation: BAB82475.1.
CU329672 Genomic DNA. Translation: CAA20365.1.
PIRiT41536.
RefSeqiNP_588267.1. NM_001023257.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CU9X-ray1.80A1-161[»]
2DZEX-ray1.80A/B1-161[»]
2Z34X-ray2.40A/B1-161[»]
2Z3FX-ray2.70A/B/C/D/E/F/G/H1-161[»]
ProteinModelPortaliO74515.
SMRiO74515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276128. 72 interactors.
MINTiMINT-4679711.

Proteomic databases

MaxQBiO74515.
PRIDEiO74515.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC663.05c.1; SPCC663.05c.1:pep; SPCC663.05c.
GeneIDi2539568.
KEGGispo:SPCC663.05c.

Organism-specific databases

EuPathDBiFungiDB:SPCC663.05c.
PomBaseiSPCC663.05c. cia1.

Phylogenomic databases

HOGENOMiHOG000197425.
InParanoidiO74515.
KOiK10753.
OMAiCAYEDNE.
OrthoDBiEOG092C4LUM.
PhylomeDBiO74515.

Miscellaneous databases

EvolutionaryTraceiO74515.
PROiO74515.

Family and domain databases

Gene3Di2.60.40.1490. 1 hit.
InterProiIPR006818. ASF1-like.
IPR017282. Hist_deposition_Asf1.
[Graphical view]
PANTHERiPTHR12040. PTHR12040. 1 hit.
PfamiPF04729. ASF1_hist_chap. 1 hit.
[Graphical view]
PIRSFiPIRSF037759. Histone_Asf1. 1 hit.
SUPFAMiSSF101546. SSF101546. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiASF1_SCHPO
AccessioniPrimary (citable) accession number: O74515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.