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Protein

DNA mismatch repair protein msh6

Gene

msh6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1024 – 1031ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • maintenance of DNA repeat elements Source: PomBase
  • meiotic mismatch repair Source: GO_Central
  • mismatch repair Source: PomBase
  • reciprocal meiotic recombination Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein msh6
Gene namesi
Name:msh6
ORF Names:SPCC285.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC285.16c.
PomBaseiSPCC285.16c. msh6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromosome Source: GO_Central
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001152121 – 1254DNA mismatch repair protein msh6Add BLAST1254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Phosphoserine1 Publication1
Modified residuei299Phosphoserine1 Publication1
Modified residuei307Phosphoserine1 Publication1
Modified residuei309Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74502.
PRIDEiO74502.

PTM databases

iPTMnetiO74502.

Interactioni

Subunit structurei

Heterodimer of msh2 and msh6.By similarity

Protein-protein interaction databases

BioGridi275785. 41 interactors.
MINTiMINT-4679601.

Structurei

3D structure databases

ProteinModelPortaliO74502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

HOGENOMiHOG000189303.
InParanoidiO74502.
KOiK08737.
OMAiKVPSNWT.
OrthoDBiEOG092C0EWT.
PhylomeDBiO74502.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGNVGKQR EKTKDSSAKT KQKTLFGFFS KIPNVKQEKS DSTLSSSSNH
60 70 80 90 100
DSNHDTPADV DNSSNVNKNS SSPERELPTS PSHHANTEID SSSSMLPPPS
110 120 130 140 150
SDPFSSPLSS SLHRSSPKRP HDSLGEESPG KLLRTSVKQE PDSEEEIDSP
160 170 180 190 200
TKKKSFKSLD TSIFQAEDQF RHPVSSKLEN SELSEVDKPF IASRRSRKPV
210 220 230 240 250
SYAESDEDED FDDAPTKGSR HKRIVSDDES DDYVEPDHIS EASSEASLPI
260 270 280 290 300
DEVESMDEDV DGYSDHSVSV AAPIPKKESR KESSNSLYES YRLGSQIASP
310 320 330 340 350
SPSVSGSASP TKSNKNGVLN REEKRRQRME AFKKENNERY EWLLDVRDAD
360 370 380 390 400
QNRVGDPNYD PRTLYIPPSA WATFKPFEKQ FWKIKKDLMD TVVFFQKGKF
410 420 430 440 450
YELYENDAAI GHQVFSLKLT DRVNMKMVGI PEASFDYWAS QFIAKGYRIA
460 470 480 490 500
RVDQLETALG KEIKDRQRTQ KEEKVVQRGL TQVLTSGTLV DEAMLTSDLS
510 520 530 540 550
TYCMAIKESL QSDNEEPSFG ICFIDTSTGG FHMCEFTDDI HRTKLDTLLT
560 570 580 590 600
QVRPKELILE KSKISQKSIR AIKYCVSSSS IWNFIKPYTE FWDNERVERE
610 620 630 640 650
IIAGDYFKNG LEGAPKILKS YLSEKPLAIS AFGALFWYLR QLKLDKDMCS
660 670 680 690 700
MGNFDEYDAS QQSTSLLMNG QTLKNLEIFS NSFDGGSEGT LFHLLCRCVT
710 720 730 740 750
PFGKRLFHTW LCHPLRSGTA INARLDVVEL IADNPVIRDT IWGFLHKLPD
760 770 780 790 800
LERLISRVHA GRSKPADFVR VLEGFQRINS AFDQLREEFM EVAEGTLLGE
810 820 830 840 850
IIQSAPNMKE ELEAWTRAFN WQKASEEGVF EPEIGFEAEY DTSQKYQSEL
860 870 880 890 900
KNELYALLEQ YKKQLRCSSL NFKNIGKEVY QVEVPSDVKV PVNWCKMSGT
910 920 930 940 950
KKTNRYYNDE LRKKIKKLLE AEELHLAIMS RMQEKFYIRF DSNYEQWLAL
960 970 980 990 1000
IKYTASIDCF FSLSQAAAAL GEPYCRPEII EQKDGHLYFE ELRHPCINAS
1010 1020 1030 1040 1050
AASTFVPNDV VLGGESPNMI VLTGPNMAGK STLLRQVCIA VIMAQLGCWV
1060 1070 1080 1090 1100
PAKRASITPM TSIYTRLGAN DDIMSARSTF MVELSETKKI LDECGPKSLV
1110 1120 1130 1140 1150
ILDELGRGTS TYDGHAIAYA VLHHLVSNIG CLGFFSTHYQ SLCVDFMHHR
1160 1170 1180 1190 1200
QVRLMQMAAA VDEKIRRVTF LYKLEDGICP KSYGMNVASM AGLPEKVIDA
1210 1220 1230 1240 1250
AEEKASELEQ ASASFINASD DIALMSDFLQ VLRISKSIEP LTAVNIPLIL

DSFE
Length:1,254
Mass (Da):141,512
Last modified:November 1, 1998 - v1
Checksum:i7A28EC8DD8D2845B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207839 Genomic DNA. Translation: AAF20943.1.
CU329672 Genomic DNA. Translation: CAA20855.1.
PIRiT41262.
RefSeqiNP_588344.1. NM_001023335.2.

Genome annotation databases

EnsemblFungiiSPCC285.16c.1; SPCC285.16c.1:pep; SPCC285.16c.
GeneIDi2539215.
KEGGispo:SPCC285.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207839 Genomic DNA. Translation: AAF20943.1.
CU329672 Genomic DNA. Translation: CAA20855.1.
PIRiT41262.
RefSeqiNP_588344.1. NM_001023335.2.

3D structure databases

ProteinModelPortaliO74502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275785. 41 interactors.
MINTiMINT-4679601.

PTM databases

iPTMnetiO74502.

Proteomic databases

MaxQBiO74502.
PRIDEiO74502.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC285.16c.1; SPCC285.16c.1:pep; SPCC285.16c.
GeneIDi2539215.
KEGGispo:SPCC285.16c.

Organism-specific databases

EuPathDBiFungiDB:SPCC285.16c.
PomBaseiSPCC285.16c. msh6.

Phylogenomic databases

HOGENOMiHOG000189303.
InParanoidiO74502.
KOiK08737.
OMAiKVPSNWT.
OrthoDBiEOG092C0EWT.
PhylomeDBiO74502.

Enzyme and pathway databases

ReactomeiR-SPO-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Miscellaneous databases

PROiO74502.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSH6_SCHPO
AccessioniPrimary (citable) accession number: O74502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.