O74499 (LSM7_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U6 snRNA-associated Sm-like protein LSm7

Gene names

Name:	lsm7
ORF Names:	SPCC285.12

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Probable component of the spliceosome.
Subcellular location	Cytoplasm. Nucleus Ref.2.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing rRNA processing tRNA processing
Cellular component	Cytoplasm Nucleus Spliceosome
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA catabolic process Inferred from sequence or structural similarity. Source: PomBase mRNA cis splicing, via spliceosome Inferred from sequence orthology. Source: PomBase maturation of SSU-rRNA Inferred from sequence orthology. Source: PomBase tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	U4/U6 x U5 tri-snRNP complex Inferred from sequence orthology. Source: PomBase U6 snRNP Inferred from sequence orthology. Source: PomBase cytosol Inferred from direct assay Ref.2. Source: PomBase spliceosomal complex Non-traceable author statement. Source: PomBase
Molecular_function	RNA binding Inferred from sequence or structural similarity. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 113

113

U6 snRNA-associated Sm-like protein LSm7

PRO_0000317308

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

113

Helix Strand Turn

Details...

Beta strand

34 – 40

7

Beta strand

45 – 53

9

Beta strand

59 – 67

9

Beta strand

80 – 88

9

Turn

90 – 92

3

Beta strand

93 – 98

6

Sequences

	Sequence		Length	Mass (Da)
	O74499 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 4B257009949187E5	FASTA	113	12,474
	10 20 30 40 50 60 MSSLQKRPGP GNSSQPTERP RKESILDLSR YQDQRIQATF TGGRQITGIL KGFDQLMNLV 70 80 90 100 110 LDDVEEQLRN PEDGKLTGAI RKLGLVVVRG TTLVLIAPMD GSEEIPNPFV QAE

References

[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CU329672 Genomic DNA. Translation: CAA20851.1.

PIR

T41258.

RefSeq

NP_588340.1. NM_001023331.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3SWN	X-ray	2.50	C/F/O/R	1-113	[»]
4EMK	X-ray	2.30	C	1-113	[»]

ProteinModelPortal

O74499.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-4679583.

STRING

4896.SPCC285.12-1.

Proteomic databases

PaxDb

O74499.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

SPCC285.12.1; SPCC285.12.1:pep; SPCC285.12.

GeneID

2538964.

KEGG

spo:SPCC285.12.

Organism-specific databases

PomBase

SPCC285.12.

Phylogenomic databases

eggNOG

NOG276686.

HOGENOM

HOG000223548.

KO

K12626.

OMA

VLDNTVE.

OrthoDB

EOG4BGD5N.

Family and domain databases

InterPro

IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017132. U6_snRNA_Lsm7.
[Graphical view]

Pfam

PF01423. LSM. 1 hit.
[Graphical view]

PIRSF

PIRSF037188. U6_snRNA_Lsm7. 1 hit.

SMART

SM00651. Sm. 1 hit.
[Graphical view]

SUPFAM

SSF50182. Sm_like_riboprot. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

O74499.

NextBio

20800139.

Entry information

Entry name

LSM7_SCHPO

Accession

Primary (citable) accession number: O74499

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 1, 1998
Last modified:	May 29, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program