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O74499

- LSM7_SCHPO

UniProt

O74499 - LSM7_SCHPO

Protein

U6 snRNA-associated Sm-like protein LSm7

Gene

lsm7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Probable component of the spliceosome.

    GO - Molecular functioni

    1. RNA binding Source: PomBase

    GO - Biological processi

    1. maturation of SSU-rRNA Source: PomBase
    2. mRNA catabolic process Source: PomBase
    3. mRNA cis splicing, via spliceosome Source: PomBase
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing, rRNA processing, tRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U6 snRNA-associated Sm-like protein LSm7
    Gene namesi
    Name:lsm7
    ORF Names:SPCC285.12
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC285.12.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase
    3. spliceosomal complex Source: UniProtKB-KW
    4. U4/U6 x U5 tri-snRNP complex Source: PomBase
    5. U6 snRNP Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 113113U6 snRNA-associated Sm-like protein LSm7PRO_0000317308Add
    BLAST

    Proteomic databases

    MaxQBiO74499.
    PaxDbiO74499.

    Interactioni

    Protein-protein interaction databases

    BioGridi275538. 3 interactions.
    MINTiMINT-4679583.
    STRINGi4896.SPCC285.12-1.

    Structurei

    Secondary structure

    1
    113
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 407
    Beta strandi45 – 539
    Beta strandi59 – 679
    Beta strandi80 – 889
    Turni90 – 923
    Beta strandi93 – 986

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SWNX-ray2.50C/F/O/R1-113[»]
    4EMKX-ray2.30C1-113[»]
    ProteinModelPortaliO74499.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO74499.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the snRNP Sm proteins family.Curated

    Phylogenomic databases

    eggNOGiNOG276686.
    HOGENOMiHOG000223548.
    KOiK12626.
    OMAiKPIRVKF.
    OrthoDBiEOG7PZSB0.
    PhylomeDBiO74499.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR017132. U6_snRNA_Lsm7.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037188. U6_snRNA_Lsm7. 1 hit.
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O74499-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLQKRPGP GNSSQPTERP RKESILDLSR YQDQRIQATF TGGRQITGIL    50
    KGFDQLMNLV LDDVEEQLRN PEDGKLTGAI RKLGLVVVRG TTLVLIAPMD 100
    GSEEIPNPFV QAE 113
    Length:113
    Mass (Da):12,474
    Last modified:November 1, 1998 - v1
    Checksum:i4B257009949187E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA20851.1.
    PIRiT41258.
    RefSeqiNP_588340.1. NM_001023331.2.

    Genome annotation databases

    EnsemblFungiiSPCC285.12.1; SPCC285.12.1:pep; SPCC285.12.
    GeneIDi2538964.
    KEGGispo:SPCC285.12.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA20851.1 .
    PIRi T41258.
    RefSeqi NP_588340.1. NM_001023331.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SWN X-ray 2.50 C/F/O/R 1-113 [» ]
    4EMK X-ray 2.30 C 1-113 [» ]
    ProteinModelPortali O74499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275538. 3 interactions.
    MINTi MINT-4679583.
    STRINGi 4896.SPCC285.12-1.

    Proteomic databases

    MaxQBi O74499.
    PaxDbi O74499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC285.12.1 ; SPCC285.12.1:pep ; SPCC285.12 .
    GeneIDi 2538964.
    KEGGi spo:SPCC285.12.

    Organism-specific databases

    PomBasei SPCC285.12.

    Phylogenomic databases

    eggNOGi NOG276686.
    HOGENOMi HOG000223548.
    KOi K12626.
    OMAi KPIRVKF.
    OrthoDBi EOG7PZSB0.
    PhylomeDBi O74499.

    Miscellaneous databases

    EvolutionaryTracei O74499.
    NextBioi 20800139.
    PROi O74499.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR017132. U6_snRNA_Lsm7.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037188. U6_snRNA_Lsm7. 1 hit.
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLSM7_SCHPO
    AccessioniPrimary (citable) accession number: O74499
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3