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Protein

U6 snRNA-associated Sm-like protein LSm7

Gene

lsm7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Probable component of the spliceosome.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing, rRNA processing, tRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-430039. mRNA decay by 5' to 3' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm7
Gene namesi
Name:lsm7
ORF Names:SPCC285.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC285.12.
PomBaseiSPCC285.12. lsm7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173081 – 113U6 snRNA-associated Sm-like protein LSm7Add BLAST113

Proteomic databases

MaxQBiO74499.
PRIDEiO74499.

Interactioni

Protein-protein interaction databases

BioGridi275538. 7 interactors.
MINTiMINT-4679583.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 40Combined sources7
Beta strandi45 – 53Combined sources9
Beta strandi59 – 67Combined sources9
Turni71 – 73Combined sources3
Beta strandi80 – 88Combined sources9
Turni90 – 92Combined sources3
Beta strandi93 – 98Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SWNX-ray2.50C/F/O/R1-113[»]
4EMKX-ray2.30C1-113[»]
ProteinModelPortaliO74499.
SMRiO74499.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO74499.

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

HOGENOMiHOG000223548.
InParanoidiO74499.
KOiK12626.
OMAiICPVDGM.
OrthoDBiEOG092C5VL3.
PhylomeDBiO74499.

Family and domain databases

InterProiIPR017132. Lsm7/snRNP-G.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037188. U6_snRNA_Lsm7. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

O74499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLQKRPGP GNSSQPTERP RKESILDLSR YQDQRIQATF TGGRQITGIL
60 70 80 90 100
KGFDQLMNLV LDDVEEQLRN PEDGKLTGAI RKLGLVVVRG TTLVLIAPMD
110
GSEEIPNPFV QAE
Length:113
Mass (Da):12,474
Last modified:November 1, 1998 - v1
Checksum:i4B257009949187E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20851.1.
PIRiT41258.
RefSeqiNP_588340.1. NM_001023331.2.

Genome annotation databases

EnsemblFungiiSPCC285.12.1; SPCC285.12.1:pep; SPCC285.12.
GeneIDi2538964.
KEGGispo:SPCC285.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20851.1.
PIRiT41258.
RefSeqiNP_588340.1. NM_001023331.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SWNX-ray2.50C/F/O/R1-113[»]
4EMKX-ray2.30C1-113[»]
ProteinModelPortaliO74499.
SMRiO74499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275538. 7 interactors.
MINTiMINT-4679583.

Proteomic databases

MaxQBiO74499.
PRIDEiO74499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC285.12.1; SPCC285.12.1:pep; SPCC285.12.
GeneIDi2538964.
KEGGispo:SPCC285.12.

Organism-specific databases

EuPathDBiFungiDB:SPCC285.12.
PomBaseiSPCC285.12. lsm7.

Phylogenomic databases

HOGENOMiHOG000223548.
InParanoidiO74499.
KOiK12626.
OMAiICPVDGM.
OrthoDBiEOG092C5VL3.
PhylomeDBiO74499.

Enzyme and pathway databases

ReactomeiR-SPO-430039. mRNA decay by 5' to 3' exoribonuclease.

Miscellaneous databases

EvolutionaryTraceiO74499.
PROiO74499.

Family and domain databases

InterProiIPR017132. Lsm7/snRNP-G.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037188. U6_snRNA_Lsm7. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM7_SCHPO
AccessioniPrimary (citable) accession number: O74499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.