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Protein

Probable phosphoribomutase

Gene

SPCC1840.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Converts ribose 1-phosphate to ribose 5-phosphate. Involved in ribose salvage via the pentose phosphate pathway.By similarity

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491SubstrateBy similarity
Binding sitei53 – 531SubstrateBy similarity
Active sitei149 – 1491Phosphoserine intermediateBy similarity
Metal bindingi149 – 1491Magnesium; via phosphate groupBy similarity
Metal bindingi306 – 3061MagnesiumBy similarity
Metal bindingi308 – 3081MagnesiumBy similarity
Metal bindingi310 – 3101MagnesiumBy similarity
Binding sitei380 – 3801SubstrateBy similarity
Binding sitei418 – 4181SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-3322077. Glycogen synthesis.
R-SPO-70221. Glycogen breakdown (glycogenolysis).
R-SPO-70370. Galactose catabolism.
R-SPO-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoribomutaseBy similarity (EC:5.4.2.7By similarity)
Short name:
PRM
Alternative name(s):
Phosphoglucomutase 3 homologBy similarity
Short name:
PGM 3 homolog
Gene namesi
ORF Names:SPCC1840.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1840.05c.
PomBaseiSPCC1840.05c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Probable phosphoribomutasePRO_0000315630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74478.
PRIDEiO74478.

PTM databases

iPTMnetiO74478.

Interactioni

Protein-protein interaction databases

BioGridi275497. 15 interactions.
MINTiMINT-4679430.

Structurei

3D structure databases

ProteinModelPortaliO74478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 1502Substrate bindingBy similarity
Regioni310 – 3112Substrate bindingBy similarity
Regioni404 – 4063Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

HOGENOMiHOG000268676.
InParanoidiO74478.
KOiK01835.
OMAiQAGSMGM.
OrthoDBiEOG092C13NP.
PhylomeDBiO74478.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPILQELVD EWFKLDQDET TRNEVSQLIK AEDYATLKQI MHPRIGFGTS
60 70 80 90 100
GLRAEIGAGF ARMNCLTVIQ ASQGFAEYLL QTVPSAAKLG VVIGHDHRHK
110 120 130 140 150
SNTFARLTAA VFLQKGFKTY FFDHLVHTPL VPFAVKTLGT AAGVMITASH
160 170 180 190 200
NPAAYNGYKV YWGNGCAIIP PHDKGIAACI EKNLTPITWD KNLVENHKLA
210 220 230 240 250
DRDFAVGLLK NYWSQLHEFH SENNFSLEMK SLKFVYTPIH GVGLPFVTSA
260 270 280 290 300
LHLFGEQGDM ISVPLQDSPN PDFPTVKFPN PEEEGALDLA YEQADANGIS
310 320 330 340 350
YVLATDPDAD RFAFAEKING AWRRFTGDEV GCILAYFIFQ EYKNVGKPID
360 370 380 390 400
DFYVLSTTVS SAMVKSMAKV EGFHHVETLT GFKWLGNKAL ELEKQGKFIG
410 420 430 440 450
LAYEEALGYM VGSIVRDKDG VNALITFLHL LKRLQLQNLS ITEVFEQMSK
460 470 480 490 500
KYGYYTTQNS YFLSRDTPKL RALVDALRHY DTKSGYPATL GSKKITNVRD
510 520 530 540 550
LTTGYDSSST DGKATLPVSK SSDNVTFELE NGEVIMTIRT SGTEPKLKFY
560 570 580
ICARGHSLED SIKNATEVKQ AIKSEWFHPQ QNGLEEP
Length:587
Mass (Da):65,494
Last modified:November 1, 1998 - v1
Checksum:i3A818C1C02CD5845
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20128.1.
PIRiT41173.
RefSeqiNP_588504.1. NM_001023494.2.

Genome annotation databases

EnsemblFungiiSPCC1840.05c.1; SPCC1840.05c.1:pep; SPCC1840.05c.
GeneIDi2538920.
KEGGispo:SPCC1840.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20128.1.
PIRiT41173.
RefSeqiNP_588504.1. NM_001023494.2.

3D structure databases

ProteinModelPortaliO74478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275497. 15 interactions.
MINTiMINT-4679430.

PTM databases

iPTMnetiO74478.

Proteomic databases

MaxQBiO74478.
PRIDEiO74478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1840.05c.1; SPCC1840.05c.1:pep; SPCC1840.05c.
GeneIDi2538920.
KEGGispo:SPCC1840.05c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1840.05c.
PomBaseiSPCC1840.05c.

Phylogenomic databases

HOGENOMiHOG000268676.
InParanoidiO74478.
KOiK01835.
OMAiQAGSMGM.
OrthoDBiEOG092C13NP.
PhylomeDBiO74478.

Enzyme and pathway databases

ReactomeiR-SPO-3322077. Glycogen synthesis.
R-SPO-70221. Glycogen breakdown (glycogenolysis).
R-SPO-70370. Galactose catabolism.
R-SPO-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

PROiO74478.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGM3_SCHPO
AccessioniPrimary (citable) accession number: O74478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.