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Protein

Importin subunit beta-3

Gene

sal3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the nuclear import of cdc25 and mcs1.1 Publication
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Involved in the nuclear import of cdc25 and mcs1 (PubMed:12399381). Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity1 Publication

GO - Molecular functioni

  • GTP binding Source: PomBase
  • nuclear import signal receptor activity Source: PomBase
  • nuclear localization sequence binding Source: GO_Central

GO - Biological processi

  • NLS-bearing protein import into nucleus Source: GO_Central
  • protein import into nucleus Source: PomBase
  • protein import into nucleus, translocation Source: GO_Central
  • regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • ribosomal protein import into nucleus Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit beta-3By similarity
Alternative name(s):
Importin beta sal31 Publication
Gene namesi
Name:sal31 Publication
Synonyms:pse1By similarity
ORF Names:SPCC1840.03Imported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1840.03
PomBaseiSPCC1840.03 sal3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207731 – 1095Importin subunit beta-3Add BLAST1095

Proteomic databases

MaxQBiO74476
PaxDbiO74476
PRIDEiO74476

Interactioni

Subunit structurei

Interacts with Ran; interacts specifically with the GTP-bound form of Ran (GTP-Ran), protecting it from GTP hydrolysis and nucleotide exchange.By similarity

Protein-protein interaction databases

BioGridi275952, 9 interactors
STRINGi4896.SPCC1840.03.1

Structurei

3D structure databases

ProteinModelPortaliO74476
SMRiO74476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 40HEAT 1By similarityAdd BLAST34
Repeati44 – 78HEAT 2By similarityAdd BLAST35
Repeati109 – 132HEAT 3By similarityAdd BLAST24
Repeati138 – 165HEAT 4By similarityAdd BLAST28
Repeati174 – 206HEAT 5By similarityAdd BLAST33
Repeati215 – 251HEAT 6By similarityAdd BLAST37
Repeati259 – 294HEAT 7By similarityAdd BLAST36
Repeati303 – 363HEAT 8By similarityAdd BLAST61
Repeati365 – 399HEAT 9By similarityAdd BLAST35
Repeati403 – 443HEAT 10By similarityAdd BLAST41
Repeati445 – 484HEAT 11By similarityAdd BLAST40
Repeati487 – 527HEAT 12By similarityAdd BLAST41
Repeati529 – 572HEAT 13By similarityAdd BLAST44
Repeati575 – 617HEAT 14By similarityAdd BLAST43
Repeati619 – 694HEAT 15By similarityAdd BLAST76
Repeati697 – 740HEAT 16By similarityAdd BLAST44
Repeati747 – 786HEAT 17By similarityAdd BLAST40
Repeati792 – 858HEAT 18By similarityAdd BLAST67
Repeati861 – 899HEAT 19By similarityAdd BLAST39
Repeati907 – 939HEAT 20By similarityAdd BLAST33
Repeati947 – 987HEAT 21By similarityAdd BLAST41
Repeati995 – 1026HEAT 22By similarityAdd BLAST32
Repeati1045 – 1073HEAT 23By similarityAdd BLAST29

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000209725
InParanoidiO74476
KOiK20222
OMAiNCNLPRI
OrthoDBiEOG092C0HC0
PhylomeDBiO74476

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

O74476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGFPPEVL SPLLNLVQGL SSPDNTVRND AEKSLSSDWI SQRADLLLNG
60 70 80 90 100
LAILAYQSED PAVRSFCLVL CRRISFRTLP GDSELEVFSS ISNESKQSLQ
110 120 130 140 150
SQLLACFVKE SVPTVRNKLC DTIAEIARSI YDCQGEWPEL INVIFNAVNS
160 170 180 190 200
PDESFRESVF RTITSLPRLL SGQDSAVTPL FTTGLADPSI RVRISAARAY
210 220 230 240 250
SAVILESKQS TRDQVIPLLP SLMNILPPLQ QDRDSDNLAD CLMAITEIAE
260 270 280 290 300
VFPKLFKPIF ESVIAFGLGI IKDKELDNSA RQAALELLVC FSEGAPAMCR
310 320 330 340 350
KSSDYTDQLV LQCLLLMTDV AGDPEDEAEE LQEWLNTDDL DQDESDANHV
360 370 380 390 400
VAEQAMDRLS RKLGGKTILP PSFTWLPRLI PSQKWSERHA ALMAISSIAE
410 420 430 440 450
GAEKLMKKEL SRVLDMVLPL LADPHPRVRW AACNAVGQMS TDFAPDMQVK
460 470 480 490 500
YPSRILEALV PVLESPESRV QAHAAAAMVN FSEEADNKVL EPYLDDILQR
510 520 530 540 550
LLTLLQSPKR YVQEQAVTTI ATVADAAAKK FEKYFDAIMP LLFNVLQQAD
560 570 580 590 600
GKEFRTLRGK TMECATLIAL AVGKQRFLPV SQELIQILGN IQMGITDSDD
610 620 630 640 650
PQASYLISAW GRICRVLGSD FVPFLSSVMP PLLVAATSKP DFTIIDDEVD
660 670 680 690 700
ESKYSEQDGW EFIPVHGQQV GIRTSTLEDK CTATEMLVCY AAELKADFDP
710 720 730 740 750
YVNEVLTSVV LPGLKFFFHD GVRSACCKCI PQLLNARILA SNRDPAKVNE
760 770 780 790 800
LWEPILRKLL DHIQNEPSVE MLADYFECFY QSLEISGLNL SPSSMEALVA
810 820 830 840 850
AVDLQLKGFI SRVQQREEEA KNGDIDIEED EDMILAVEND QNLLNEINKT
860 870 880 890 900
FSVVLKIHKT AFCPFWERLL PYMDGFLSGN DTVAKQWALC MMDDLIEFTG
910 920 930 940 950
PDSWNYKDHF LPYLAEGIQS SEPEIRQAAS YGIGVAAQHG GELYAEICSS
960 970 980 990 1000
ALPALFKMLE LPDARDEEQI YATENICVAI CKICRFCSQR VQDLDKVVTY
1010 1020 1030 1040 1050
WINTLPVTHD EDDAPYAYTF LAELMEQNHV AVASQMPTII TILAETFASG
1060 1070 1080 1090
VLRGRTLTRL MEASKVYLAR FPADQVNSVI ATLSVDNQRA LSAHF
Length:1,095
Mass (Da):121,869
Last modified:November 1, 1998 - v1
Checksum:i4FD3D581C7BFBC68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20126.1
AB027999 Genomic DNA Translation: BAA87303.1
PIRiT41171
RefSeqiNP_588502.1, NM_001023492.2

Genome annotation databases

EnsemblFungiiSPCC1840.03.1; SPCC1840.03.1:pep; SPCC1840.03
GeneIDi2539387
KEGGispo:SPCC1840.03

Entry informationi

Entry nameiIMB3_SCHPO
AccessioniPrimary (citable) accession number: O74476
Secondary accession number(s): Q9US74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health