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Protein

1,3-beta-glucan synthase component bgs4

Gene

bgs4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucose + ((1->3)-beta-D-glucosyl)(n) = UDP + ((1->3)-beta-D-glucosyl)(n+1).

GO - Molecular functioni

  • 1,3-beta-D-glucan synthase activity Source: PomBase

GO - Biological processi

  • fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process Source: PomBase
  • fungal-type cell wall biogenesis Source: PomBase
  • glucan biosynthetic process Source: PomBase
  • mitotic actomyosin contractile ring contraction Source: PomBase
  • primary cell septum biogenesis Source: PomBase
  • regulation of establishment of actomyosin contractile ring localization involved in mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.34. 5613.

Protein family/group databases

CAZyiGT48. Glycosyltransferase Family 48.

Names & Taxonomyi

Protein namesi
Recommended name:
1,3-beta-glucan synthase component bgs4 (EC:2.4.1.34)
Alternative name(s):
1,3-beta-D-glucan-UDP glucosyltransferase
Gene namesi
Name:bgs4
ORF Names:SPCC1840.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1840.02c.
PomBaseiSPCC1840.02c. bgs4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei519 – 53921HelicalSequence analysisAdd
BLAST
Transmembranei557 – 57721HelicalSequence analysisAdd
BLAST
Transmembranei596 – 61621HelicalSequence analysisAdd
BLAST
Transmembranei628 – 64821HelicalSequence analysisAdd
BLAST
Transmembranei687 – 70721HelicalSequence analysisAdd
BLAST
Transmembranei750 – 77021HelicalSequence analysisAdd
BLAST
Transmembranei1362 – 138221HelicalSequence analysisAdd
BLAST
Transmembranei1421 – 144121HelicalSequence analysisAdd
BLAST
Transmembranei1507 – 152721HelicalSequence analysisAdd
BLAST
Transmembranei1531 – 155121HelicalSequence analysisAdd
BLAST
Transmembranei1624 – 164421HelicalSequence analysisAdd
BLAST
Transmembranei1677 – 169721HelicalSequence analysisAdd
BLAST
Transmembranei1713 – 173321HelicalSequence analysisAdd
BLAST
Transmembranei1748 – 176821HelicalSequence analysisAdd
BLAST
Transmembranei1815 – 183521HelicalSequence analysisAdd
BLAST
Transmembranei1877 – 189721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • 1,3-beta-D-glucan synthase complex Source: InterPro
  • actomyosin contractile ring Source: PomBase
  • barrier septum Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytoplasm Source: PomBase
  • endoplasmic reticulum Source: PomBase
  • growing cell tip Source: PomBase
  • integral component of plasma membrane Source: PomBase
  • mating projection tip Source: PomBase
  • new growing cell tip Source: PomBase
  • plasma membrane of cell tip Source: PomBase
  • primary cell septum Source: PomBase
  • site of polarized growth Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195519551,3-beta-glucan synthase component bgs4PRO_0000121724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei965 – 9651Phosphotyrosine1 Publication
Modified residuei969 – 9691Phosphoserine1 Publication
Modified residuei971 – 9711Phosphoserine1 Publication
Modified residuei976 – 9761Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74475.
PRIDEiO74475.

PTM databases

iPTMnetiO74475.

Interactioni

Protein-protein interaction databases

BioGridi275403. 10 interactions.
MINTiMINT-4679385.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 48 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000216604.
InParanoidiO74475.
KOiK00706.
OMAiEMDYYGR.
OrthoDBiEOG7JT74G.
PhylomeDBiO74475.

Family and domain databases

InterProiIPR026899. FKS1-like_dom1.
IPR003440. Glyco_trans_48.
[Graphical view]
PfamiPF14288. FKS1_dom1. 1 hit.
PF02364. Glucan_synthase. 1 hit.
[Graphical view]
SMARTiSM01205. FKS1_dom1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNNENVSG ITGHDAVSDD QYAYDSEVYD DQNAYQRQPA DAYSNEEFLD
60 70 80 90 100
QADYDSMYGE GYNGYDYPTG VTESYGDEYT PVDTASSGIN QYSTEKGKFT
110 120 130 140 150
RPSDEYESEY SDYNAQPSDA NNFYNLRGDG RYNAYDPSSD SLANVYNSVP
160 170 180 190 200
YGSSPYDFSN SSFVGNSGSG TPLDGDSGSF YADSANLTNR EPYPAWTPEN
210 220 230 240 250
ELPLTKEEIE DIFIDLTNKL GFQRDSMRNM YDFFMCLLDS RASRMTPDQA
260 270 280 290 300
LLTLHADYIG SDIANYKKWY FASQMDREDA VGLANVGIYG GKVTSIKEKG
310 320 330 340 350
KFFSRNKKAP KVVKPPRKSR FKRKKKKEQP EEAEDEYIDV NTDDSLESAE
360 370 380 390 400
YRWRSHMRSM TQFERAQQIA LWLLLWGEAN NVRFMPEVIA FLFKCAYDYI
410 420 430 440 450
ISPEAQNVTE PVPEGYYLDN IVSPLYQYMH DQQFEIINGK YVRRERPHDQ
460 470 480 490 500
LIGYDDINQL FWHAEGIARL IFEDGTRLID IPASERFHRL PEVQWNRAFY
510 520 530 540 550
KTYYESRSWF HLITNFNRIW VIHFGMFWYF TAFNSPTLYT KPFHQRDGPK
560 570 580 590 600
PTGASQWAAV ACTSVVSCII MAAASLCEYL FVPRRFPGSK PIWKRLCIIV
610 620 630 640 650
LIAIINLIPI VYIFGFSSKH QQRSGRRIAV GVVAFLMSIA TYVYFSLVPL
660 670 680 690 700
QSTFGKLSVK DSRKYLANKY FTSNFAPLKF DNQALSVIIW VCVFTCKFAE
710 720 730 740 750
SYFFLTLSIR DPIIVLSTMR PYLCSIYWAG SRLCFVQPRI ILGIMYFTDL
760 770 780 790 800
ILFFLDTYLW YIIFNTIFSV LRSFVLGISI LTPWRNIFSR MPQRIYGKIL
810 820 830 840 850
ATNDMEIKYK PKILISQIWN AIVISMYREH LLSIDHVQRL LYHQVPAEEG
860 870 880 890 900
RRTLRTPTFF VSQDDNIVHT TFFPANSEAE RRLSFFAQSL ATPIPEPVPV
910 920 930 940 950
DNMPTFTVLI PHYAEKILLS LREIIREEDQ LSRVTLLEYL KQLHPVEWDC
960 970 980 990 1000
FVKDTKILVE ENAPYENDSV SEKEGTYKSK VDDLPFYCIG FKSAMPEYTL
1010 1020 1030 1040 1050
RTRIWASLRS QTLYRTISGF MNYSRAIKLL YRVENPEIVQ MFGGNTDRLE
1060 1070 1080 1090 1100
RELDRMARRK FKLVVSMQRY AKFTKEEYEN AEFLLRAYPD LQIAYLDEDP
1110 1120 1130 1140 1150
PEEEGAEPQL FAALIDGHSE IMENERRRPK YRIRLSGNPI LGDGKSDNQN
1160 1170 1180 1190 1200
MSLPFYRGEY IQLIDANQDN YLEECLKIRS VLAEFEEMET DNVNPYSESA
1210 1220 1230 1240 1250
RERNKHPVAI LGAREYIFSE NIGILGDVAA GKEQTFGTLF SRTLAQIGGK
1260 1270 1280 1290 1300
LHYGHPDFLN GIFMTTRGGV SKAQKGLHVN EDIYAGMNAM LRGGRIKHCE
1310 1320 1330 1340 1350
YFQCGKGRDL GFGSILNFNT KVGTGMGEQM LSREYYYLGT QLQLDRFLSF
1360 1370 1380 1390 1400
YFAHPGFHLN NMFIMLSVQL FMVVLINLGA IYHVVTVCYY NGNQKLSYDT
1410 1420 1430 1440 1450
SIVPRGCYQL GPVLSWLKRC VISIFIVFWI SFIPLTVHEL IERGVWRATK
1460 1470 1480 1490 1500
RFFKQIGSFS PLFEVFTCQV YSQAITSDLA YGGARYIGTG RGFATARLPF
1510 1520 1530 1540 1550
SILYSRFAVP SIYIGARFLM MLLFGTMTVW VAHLIYWWVS IMALCVAPFL
1560 1570 1580 1590 1600
FNPHQFDWND FFVDYREFIR WLSRGNSRSH ANSWIGYCRL TRTRITGYKR
1610 1620 1630 1640 1650
RVLGQPSDKI SMDTPRAKFT NVFFSDVLIP ALLAAGAIIP YFFINSQPGN
1660 1670 1680 1690 1700
PMFITDPNNP SPYVHDTKTG TNPILRLVII SLIPIAAGFG MSGFFGGMAC
1710 1720 1730 1740 1750
CLGPAFGLCC KKFPSIFAAI AHTIQIFIFI AIFEVCWFLD GWSLPKTVLA
1760 1770 1780 1790 1800
FCAVTAIHRF IFKILTLLCL SREVKQDSAN ISWWSGKWYG KGYGYHAFTL
1810 1820 1830 1840 1850
PAREFVCKAI ELNLFATDFF LGHLLLFFML PVICIPYIDR WHSVLLFWLR
1860 1870 1880 1890 1900
PSRQIRPPIF STKQNRLRKR IVRRYSALYF SILVIFLILI IVPLAAGAEI
1910 1920 1930 1940 1950
RQGLTASEAV AKGAVGWNQT NSSIGSGIIQ PRDTNYTANY SFWYDRYHFE

FNTTY
Length:1,955
Mass (Da):225,187
Last modified:November 1, 1998 - v1
Checksum:i4B37A5F0A862E401
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1733 – 17331F → W in BAA13851 (PubMed:9501991).Curated
Sequence conflicti1809 – 18091A → D in BAA13851 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20125.1.
D89189 mRNA. Translation: BAA13851.1.
PIRiT41170.
T42747.
RefSeqiNP_588501.1. NM_001023491.2.

Genome annotation databases

EnsemblFungiiSPCC1840.02c.1; SPCC1840.02c.1:pep; SPCC1840.02c.
GeneIDi2538822.
KEGGispo:SPCC1840.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20125.1.
D89189 mRNA. Translation: BAA13851.1.
PIRiT41170.
T42747.
RefSeqiNP_588501.1. NM_001023491.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275403. 10 interactions.
MINTiMINT-4679385.

Protein family/group databases

CAZyiGT48. Glycosyltransferase Family 48.

PTM databases

iPTMnetiO74475.

Proteomic databases

MaxQBiO74475.
PRIDEiO74475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1840.02c.1; SPCC1840.02c.1:pep; SPCC1840.02c.
GeneIDi2538822.
KEGGispo:SPCC1840.02c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1840.02c.
PomBaseiSPCC1840.02c. bgs4.

Phylogenomic databases

HOGENOMiHOG000216604.
InParanoidiO74475.
KOiK00706.
OMAiEMDYYGR.
OrthoDBiEOG7JT74G.
PhylomeDBiO74475.

Enzyme and pathway databases

BRENDAi2.4.1.34. 5613.

Miscellaneous databases

PROiO74475.

Family and domain databases

InterProiIPR026899. FKS1-like_dom1.
IPR003440. Glyco_trans_48.
[Graphical view]
PfamiPF14288. FKS1_dom1. 1 hit.
PF02364. Glucan_synthase. 1 hit.
[Graphical view]
SMARTiSM01205. FKS1_dom1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1681-1955.
    Strain: PR745.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-965; SER-969; SER-971 AND THR-976, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiBGS4_SCHPO
AccessioniPrimary (citable) accession number: O74475
Secondary accession number(s): P78840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.