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Protein

Septation initiation network scaffold protein cdc11

Gene

cdc11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the onset of septum formation. Involved in the organization of astral microtubules during mitosis. Acts as a bridge between sid4 and the other SIN proteins mediating their association with the spindle pole body (SPB). The sid4-cdc11 complex organizes a signaling hub on the SPB which coordinates cell and nuclear division.2 Publications

GO - Molecular functioni

  • protein complex scaffold Source: PomBase

GO - Biological processi

  • barrier septum assembly Source: PomBase
  • cellular protein localization Source: PomBase
  • mitotic cytokinesis Source: PomBase
  • septation initiation signaling Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Septation initiation network scaffold protein cdc11
Short name:
SIN scaffold protein cdc11
Alternative name(s):
Cell division control protein 11
Gene namesi
Name:cdc11
ORF Names:SPCC1739.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.11c.
PomBaseiSPCC1739.11c. cdc11.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cytoplasm Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi103S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi136S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi199S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi208S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi360S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi393S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi558S → A: No phosphorylation by cdk1. 1 Publication1
Mutagenesisi767N → M in cdc11-136; normal interaction with sid4; normal localization at the SPB. 1 Publication1
Mutagenesisi947R → A in cdc11-123; no interaction with sid4; does not localize at the SPB. 1 Publication1
Mutagenesisi1041T → I in cdc11-123; no interaction with sid4; does not localize at the SPB. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003391311 – 1045Septation initiation network scaffold protein cdc11Add BLAST1045

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei360Phosphoserine1 Publication1
Modified residuei558Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated by cdc7 and cdk1. Hyperphosphorylated during anaphase. Dephosphorylated by par1.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74473.
PRIDEiO74473.

PTM databases

iPTMnetiO74473.

Interactioni

Subunit structurei

Interacts with sid4. When hyperphosphorylated, interacts with byr4. Also interacts with spg1, sid2, cdc13 and cdc16.3 Publications

GO - Molecular functioni

  • protein complex scaffold Source: PomBase

Protein-protein interaction databases

BioGridi275721. 48 interactors.
IntActiO74473. 1 interactor.
MINTiMINT-4679361.

Structurei

3D structure databases

ProteinModelPortaliO74473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati604 – 625LRR 1Add BLAST22
Repeati627 – 646LRR 2Add BLAST20
Repeati647 – 668LRR 3Add BLAST22
Repeati669 – 690LRR 4Add BLAST22
Repeati691 – 712LRR 5Add BLAST22
Repeati713 – 734LRR 6Add BLAST22
Repeati736 – 757LRR 7Add BLAST22
Repeati758 – 779LRR 8Add BLAST22
Repeati780 – 801LRR 9Add BLAST22
Repeati802 – 822LRR 10Add BLAST21
Repeati846 – 867LRR 11Add BLAST22
Repeati868 – 889LRR 12Add BLAST22
Repeati892 – 913LRR 13Add BLAST22
Repeati914 – 935LRR 14Add BLAST22
Repeati940 – 962LRR 15Add BLAST23
Domaini1005 – 1043LRRCTAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 201Ser-richAdd BLAST108

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

InParanoidiO74473.
KOiK20237.
OMAiGESHAAN.
OrthoDBiEOG092C3MZS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLWLEHDL SEEWIPQPQE QGSDNSSEPP TTSNVNNTQS TGRGSSGTST
60 70 80 90 100
EHGTFKKGRN DAPDVPQWKQ VNAKNPVARD IFARLDLENM FEESSKQSPP
110 120 130 140 150
SKSPTKNPSK KSSNNSSRRS SSSVGKLSNV SNMQSSPSKD PFVSQDYEKE
160 170 180 190 200
SISSSQFSKK YSEGSLKSQQ SNTRSNSVHE KQNTDHASNA SSSSSVVSSP
210 220 230 240 250
SLKPNNTSPL KLFQGASDPF TREHLNQLTQ DVKSNSFENG EKQFSLPEPR
260 270 280 290 300
RPQKPMRTTE RKASLNTKDL YQEVEEVMAR LRGRMPNSGR ESTIFLPRKL
310 320 330 340 350
SGLREEEEQD EISVEVSQED SSNAFPSLSD QLHLKSLQSM KRVTSIFNDN
360 370 380 390 400
DDSFPSASSS PQRQAYMTDK MPLREIDVGS SQSSSKTARL NSSPKSTLKT
410 420 430 440 450
SSVKTRRSHS AQSSRKVSDY PNMVVITPAD LPEGIDTTQG SMEFDRIHNR
460 470 480 490 500
WRRKGHDSDL GFDFETDEDA SLSHPERTIL FKAASTRHQA NNDPNNLEKQ
510 520 530 540 550
QPHSFPLRKQ NVAQSEFPKH SLRDNSENAP QILSSFHDLS LQNESFDEMF
560 570 580 590 600
NGRYENGSPI PFISSGSGLK SKADKDAEYS FSVSRQSIIQ ILSDVEPYEP
610 620 630 640 650
FWKRIIQLDI SRRHLDSLIG LSELCPSIEE LTLEGNEIAY LTGCPVTIRD
660 670 680 690 700
LNAVENRLSS LTSFSNLLNL QYLDISYNQL EDLTGLSSLI HLRELKVDSN
710 720 730 740 750
HLWSLDGIQH LDGLLKLSAC NNRIKELSFT NSNLHRLEEL LLGNNEIEEI
760 770 780 790 800
EEISSLQNLM VLQLDNNKLT NLKASQPMIH LRILRISNNA IHQLEVDQFP
810 820 830 840 850
HLRTLYMDLN RFNRPPDIRR LKRLVNFSFR TQDPEASNFV IQPSLDIRNL
860 870 880 890 900
YLSNNTFVTL DCKHMFLGVR YLELANVQLK EVPKYIATSM PNLRVLDLSH
910 920 930 940 950
NYISDIESLK PLQMIHRLYL VGNRIKKMRN LCDILANLKQ LNVLDLRMNP
960 970 980 990 1000
LNFNIYPVID DSIYELSAAS KYQQSINQKG HHRKEDPQKQ WQEKELAFSS
1010 1020 1030 1040
TLSEAWRTRR KMYAEAILLA CPHLEWLDGS DVSQSSRAAF TKSSN
Length:1,045
Mass (Da):118,628
Last modified:November 1, 1998 - v1
Checksum:iE66CBF374B00B046
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20785.1.
PIRiT41119.
RefSeqiNP_588419.1. NM_001023410.2.

Genome annotation databases

EnsemblFungiiSPCC1739.11c.1; SPCC1739.11c.1:pep; SPCC1739.11c.
GeneIDi2539149.
KEGGispo:SPCC1739.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20785.1.
PIRiT41119.
RefSeqiNP_588419.1. NM_001023410.2.

3D structure databases

ProteinModelPortaliO74473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275721. 48 interactors.
IntActiO74473. 1 interactor.
MINTiMINT-4679361.

PTM databases

iPTMnetiO74473.

Proteomic databases

MaxQBiO74473.
PRIDEiO74473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1739.11c.1; SPCC1739.11c.1:pep; SPCC1739.11c.
GeneIDi2539149.
KEGGispo:SPCC1739.11c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.11c.
PomBaseiSPCC1739.11c. cdc11.

Phylogenomic databases

InParanoidiO74473.
KOiK20237.
OMAiGESHAAN.
OrthoDBiEOG092C3MZS.

Miscellaneous databases

PROiO74473.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC11_SCHPO
AccessioniPrimary (citable) accession number: O74473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.