O74471 (COX13_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 6A, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide VIa

Gene names

Name:	cox13
ORF Names:	SPCC1739.09c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport By similarity.
Subunit structure	Composed of at least 11 subunits By similarity.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 6A family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	mitochondrial respiratory chain complex IV Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Molecular function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro enzyme regulator activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion
	Chain	? – 130		Cytochrome c oxidase subunit 6A, mitochondrial		PRO_0000006126

Sequences

	Sequence		Length	Mass (Da)
	O74471 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 95127039255F3293	FASTA	130	15,199
	10 20 30 40 50 60 MSMMNRNIGF LSRTLKTSVP KRAGLLSFRA YSNEAKVNWL EEVQAEEEHA KRSSEFWKKV 70 80 90 100 110 120 TYYIGGPALI LASANAYYIY CKHQEHAKHV EDTDPGYSFE NLRFKKYPWG DGSKTLFWND 130 KVNHLKKDDE

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAA20783.1.
PIR	T41117.
RefSeq	NP_588417.1. NM_001023408.1.
3D structure databases
ProteinModelPortal	O74471.
ModBase	Search...
Protein-protein interaction databases
STRING	O74471.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC1739.09c.1; SPCC1739.09c.1:pep; SPCC1739.09c.
GeneID	2538807.
GenomeReviews	Gene locus cox13 in contig CU329672_GR.
KEGG	spo:SPCC1739.09c.
NMPDR	fig|4896.1.peg.755.
Organism-specific databases
GeneDB_Spombe	SPCC1739.09c.
Phylogenomic databases
eggNOG	fuNOG09266.
GeneTree	EFGT00050000005114.
HOGENOM	HBG324116.
OrthoDB	EOG41CB5V.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000329-MONOMER.
Gene expression databases
ArrayExpress	O74471.
Family and domain databases
InterPro	IPR001349. Cyt_c_oxidase_su6a. IPR018507. Cyt_c_oxidase_su6a_CS. [Graphical view]
Gene3D	G3DSA:4.10.95.10. COX6A. 1 hit.
KO	K02266.
PANTHER	PTHR11504. COX6A. 1 hit.
Pfam	PF02046. COX6A. 1 hit. [Graphical view]
PIRSF	PIRSF000277. COX6A1. 1 hit.
ProDom	PD006036. Cyt_c_oxidase_su6a. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF81411. COX6A. 1 hit.
PROSITE	PS01329. COX6A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX13_SCHPO

Accession

Primary (citable) accession number: O74471

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program