Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O74468

- SUMT_SCHPO

UniProt

O74468 - SUMT_SCHPO

Protein

Probable uroporphyrinogen-III C-methyltransferase

Gene

SPCC1739.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Siroheme synthase involved in methionine biosynthesis.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

    GO - Molecular functioni

    1. precorrin-2 dehydrogenase activity Source: InterPro
    2. uroporphyrin-III C-methyltransferase activity Source: PomBase

    GO - Biological processi

    1. heme biosynthetic process Source: PomBase
    2. methionine biosynthetic process Source: PomBase
    3. siroheme biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
    Gene namesi
    ORF Names:SPCC1739.06c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC1739.06c.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Probable uroporphyrinogen-III C-methyltransferasePRO_0000150386Add
    BLAST

    Proteomic databases

    MaxQBiO74468.

    Interactioni

    Protein-protein interaction databases

    BioGridi275519. 24 interactions.
    STRINGi4896.SPCC1739.06c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO74468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi11 – 155Poly-Val

    Sequence similaritiesi

    Belongs to the precorrin methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0007.
    HOGENOMiHOG000194244.
    KOiK00589.
    OMAiFIARKFP.
    OrthoDBiEOG7WHHP1.
    PhylomeDBiO74468.

    Family and domain databases

    Gene3Di3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR016040. NAD(P)-bd_dom.
    IPR006367. Sirohaem_synthase_N.
    IPR012066. SUMT_yeast.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view]
    PfamiPF13241. NAD_binding_7. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036555. SUMT_yeast. 1 hit.
    SUPFAMiSSF53790. SSF53790. 1 hit.
    TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEiPS00840. SUMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74468-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVSWSLKDA VVVVVGSGKN AYRRVNLCLS ENSSKIFWFC RSSADGGFDV    50
    GHLQLDAKKS DAIEILPISE FDPVRSLTTL GKEETDFLVD AVFVSESNHH 100
    EKEILHRTCK RYRIPLNIID NPSLCSFTLP ATWSEPPLQI SLSTSSNGCR 150
    LAQRLLRHVV SSLPSGMPEA IERFGRVRAI TKTPEKKQWI NHVSDFWPLE 200
    KLVRMTEDDL LAIVSDNFSL PLSSSQSSSL ANSYESLSTT LDKPSLTLDP 250
    EAFPTHKRGS IALIGSGPGS PDLLTVAARK AIMKADYVLA DKLVPEAVLQ 300
    LIPRHTPLFI ARKFPGNADK AQDELHQVAF DALSRGDYVV RLKQGDPYIY 350
    GRGGEEYLFF TQHGYVPTVI PGISSALMAP ISAGIPVTHR GVADQFLVCT 400
    GTGQKGSMPK IPSFVPTQTT VFLMALHRLE ILVQALIESG WPRVLPVCIA 450
    ERVSCPDQRF IFSTLEDVVE EYNKYESLPP GLLITGYSCN TLRNTA 496
    Length:496
    Mass (Da):54,712
    Last modified:November 1, 1998 - v1
    Checksum:i296D3CD7B9C1536E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti330 – 3301F → L in BAA13785. (PubMed:9501991)Curated
    Sequence conflicti343 – 3431K → E(PubMed:9501991)Curated
    Sequence conflicti345 – 3451G → S(PubMed:9501991)Curated
    Sequence conflicti379 – 3791A → P in BAA13785. (PubMed:9501991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA20780.1.
    D89123 mRNA. Translation: BAA13785.1.
    AB009602 mRNA. Translation: BAA23999.1.
    PIRiT41114.
    T42365.
    T43302.
    RefSeqiNP_588414.1. NM_001023405.2.

    Genome annotation databases

    EnsemblFungiiSPCC1739.06c.1; SPCC1739.06c.1:pep; SPCC1739.06c.
    GeneIDi2538945.
    KEGGispo:SPCC1739.06c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA20780.1 .
    D89123 mRNA. Translation: BAA13785.1 .
    AB009602 mRNA. Translation: BAA23999.1 .
    PIRi T41114.
    T42365.
    T43302.
    RefSeqi NP_588414.1. NM_001023405.2.

    3D structure databases

    ProteinModelPortali O74468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275519. 24 interactions.
    STRINGi 4896.SPCC1739.06c-1.

    Proteomic databases

    MaxQBi O74468.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC1739.06c.1 ; SPCC1739.06c.1:pep ; SPCC1739.06c .
    GeneIDi 2538945.
    KEGGi spo:SPCC1739.06c.

    Organism-specific databases

    PomBasei SPCC1739.06c.

    Phylogenomic databases

    eggNOGi COG0007.
    HOGENOMi HOG000194244.
    KOi K00589.
    OMAi FIARKFP.
    OrthoDBi EOG7WHHP1.
    PhylomeDBi O74468.

    Miscellaneous databases

    NextBioi 20800120.
    PROi O74468.

    Family and domain databases

    Gene3Di 3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR016040. NAD(P)-bd_dom.
    IPR006367. Sirohaem_synthase_N.
    IPR012066. SUMT_yeast.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view ]
    Pfami PF13241. NAD_binding_7. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036555. SUMT_yeast. 1 hit.
    SUPFAMi SSF53790. SSF53790. 1 hit.
    TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEi PS00840. SUMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 246-496.
      Strain: PR745.
    3. "S.pombe MET1 homolog."
      Kawamukai M.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 407-496.

    Entry informationi

    Entry nameiSUMT_SCHPO
    AccessioniPrimary (citable) accession number: O74468
    Secondary accession number(s): P78775, Q9URL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3