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Protein

Probable uroporphyrinogen-III C-methyltransferase

Gene

SPCC1739.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Siroheme synthase involved in methionine biosynthesis.By similarity

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Gene namesi
ORF Names:SPCC1739.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.06c.
PomBaseiSPCC1739.06c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable uroporphyrinogen-III C-methyltransferasePRO_0000150386Add
BLAST

Proteomic databases

MaxQBiO74468.

Interactioni

Protein-protein interaction databases

BioGridi275519. 24 interactions.
STRINGi4896.SPCC1739.06c.1.

Structurei

3D structure databases

ProteinModelPortaliO74468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 155Poly-Val

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000194244.
InParanoidiO74468.
KOiK00589.
OMAiFIARKFP.
OrthoDBiEOG7WHHP1.
PhylomeDBiO74468.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR006367. Sirohaem_synthase_N.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PANTHERiPTHR21091:SF96. PTHR21091:SF96. 1 hit.
PfamiPF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEiPS00840. SUMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVSWSLKDA VVVVVGSGKN AYRRVNLCLS ENSSKIFWFC RSSADGGFDV
60 70 80 90 100
GHLQLDAKKS DAIEILPISE FDPVRSLTTL GKEETDFLVD AVFVSESNHH
110 120 130 140 150
EKEILHRTCK RYRIPLNIID NPSLCSFTLP ATWSEPPLQI SLSTSSNGCR
160 170 180 190 200
LAQRLLRHVV SSLPSGMPEA IERFGRVRAI TKTPEKKQWI NHVSDFWPLE
210 220 230 240 250
KLVRMTEDDL LAIVSDNFSL PLSSSQSSSL ANSYESLSTT LDKPSLTLDP
260 270 280 290 300
EAFPTHKRGS IALIGSGPGS PDLLTVAARK AIMKADYVLA DKLVPEAVLQ
310 320 330 340 350
LIPRHTPLFI ARKFPGNADK AQDELHQVAF DALSRGDYVV RLKQGDPYIY
360 370 380 390 400
GRGGEEYLFF TQHGYVPTVI PGISSALMAP ISAGIPVTHR GVADQFLVCT
410 420 430 440 450
GTGQKGSMPK IPSFVPTQTT VFLMALHRLE ILVQALIESG WPRVLPVCIA
460 470 480 490
ERVSCPDQRF IFSTLEDVVE EYNKYESLPP GLLITGYSCN TLRNTA
Length:496
Mass (Da):54,712
Last modified:November 1, 1998 - v1
Checksum:i296D3CD7B9C1536E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301F → L in BAA13785 (PubMed:9501991).Curated
Sequence conflicti343 – 3431K → E (PubMed:9501991).Curated
Sequence conflicti345 – 3451G → S (PubMed:9501991).Curated
Sequence conflicti379 – 3791A → P in BAA13785 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20780.1.
D89123 mRNA. Translation: BAA13785.1.
AB009602 mRNA. Translation: BAA23999.1.
PIRiT41114.
T42365.
T43302.
RefSeqiNP_588414.1. NM_001023405.2.

Genome annotation databases

EnsemblFungiiSPCC1739.06c.1; SPCC1739.06c.1:pep; SPCC1739.06c.
GeneIDi2538945.
KEGGispo:SPCC1739.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20780.1.
D89123 mRNA. Translation: BAA13785.1.
AB009602 mRNA. Translation: BAA23999.1.
PIRiT41114.
T42365.
T43302.
RefSeqiNP_588414.1. NM_001023405.2.

3D structure databases

ProteinModelPortaliO74468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275519. 24 interactions.
STRINGi4896.SPCC1739.06c.1.

Proteomic databases

MaxQBiO74468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1739.06c.1; SPCC1739.06c.1:pep; SPCC1739.06c.
GeneIDi2538945.
KEGGispo:SPCC1739.06c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.06c.
PomBaseiSPCC1739.06c.

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000194244.
InParanoidiO74468.
KOiK00589.
OMAiFIARKFP.
OrthoDBiEOG7WHHP1.
PhylomeDBiO74468.

Miscellaneous databases

NextBioi20800120.
PROiO74468.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR006367. Sirohaem_synthase_N.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PANTHERiPTHR21091:SF96. PTHR21091:SF96. 1 hit.
PfamiPF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEiPS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 246-496.
    Strain: PR745.
  3. "S.pombe MET1 homolog."
    Kawamukai M.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 407-496.

Entry informationi

Entry nameiSUMT_SCHPO
AccessioniPrimary (citable) accession number: O74468
Secondary accession number(s): P78775, Q9URL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.