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O74468 (SUMT_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable uroporphyrinogen-III C-methyltransferase

EC=2.1.1.107
Gene names
ORF Names:SPCC1739.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Siroheme synthase involved in methionine biosynthesis By similarity.

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Sequence similarities

Belongs to the precorrin methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Probable uroporphyrinogen-III C-methyltransferase
PRO_0000150386

Regions

Compositional bias11 – 155Poly-Val

Experimental info

Sequence conflict3301F → L in BAA13785. Ref.2
Sequence conflict3431K → E Ref.2
Sequence conflict3451G → S Ref.2
Sequence conflict3791A → P in BAA13785. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O74468 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 296D3CD7B9C1536E

FASTA49654,712
        10         20         30         40         50         60 
MIVSWSLKDA VVVVVGSGKN AYRRVNLCLS ENSSKIFWFC RSSADGGFDV GHLQLDAKKS 

        70         80         90        100        110        120 
DAIEILPISE FDPVRSLTTL GKEETDFLVD AVFVSESNHH EKEILHRTCK RYRIPLNIID 

       130        140        150        160        170        180 
NPSLCSFTLP ATWSEPPLQI SLSTSSNGCR LAQRLLRHVV SSLPSGMPEA IERFGRVRAI 

       190        200        210        220        230        240 
TKTPEKKQWI NHVSDFWPLE KLVRMTEDDL LAIVSDNFSL PLSSSQSSSL ANSYESLSTT 

       250        260        270        280        290        300 
LDKPSLTLDP EAFPTHKRGS IALIGSGPGS PDLLTVAARK AIMKADYVLA DKLVPEAVLQ 

       310        320        330        340        350        360 
LIPRHTPLFI ARKFPGNADK AQDELHQVAF DALSRGDYVV RLKQGDPYIY GRGGEEYLFF 

       370        380        390        400        410        420 
TQHGYVPTVI PGISSALMAP ISAGIPVTHR GVADQFLVCT GTGQKGSMPK IPSFVPTQTT 

       430        440        450        460        470        480 
VFLMALHRLE ILVQALIESG WPRVLPVCIA ERVSCPDQRF IFSTLEDVVE EYNKYESLPP 

       490 
GLLITGYSCN TLRNTA 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 246-496.
Strain: PR745.
[3]"S.pombe MET1 homolog."
Kawamukai M.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 407-496.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA20780.1.
D89123 mRNA. Translation: BAA13785.1.
AB009602 mRNA. Translation: BAA23999.1.
PIRT41114.
T42365.
T43302.
RefSeqNP_588414.1. NM_001023405.2.

3D structure databases

ProteinModelPortalO74468.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275519. 24 interactions.
STRING4896.SPCC1739.06c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1739.06c.1; SPCC1739.06c.1:pep; SPCC1739.06c.
GeneID2538945.
KEGGspo:SPCC1739.06c.

Organism-specific databases

PomBaseSPCC1739.06c.

Phylogenomic databases

eggNOGCOG0007.
HOGENOMHOG000194244.
KOK00589.
OMAQASFIMP.
OrthoDBEOG7WHHP1.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR006367. Sirohaem_synthase_N.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
PIRSFPIRSF036555. SUMT_yeast. 1 hit.
SUPFAMSSF53790. SSF53790. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEPS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800120.
PROO74468.

Entry information

Entry nameSUMT_SCHPO
AccessionPrimary (citable) accession number: O74468
Secondary accession number(s): P78775, Q9URL1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names