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O74468

- SUMT_SCHPO

UniProt

O74468 - SUMT_SCHPO

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Protein

Probable uroporphyrinogen-III C-methyltransferase

Gene

SPCC1739.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Siroheme synthase involved in methionine biosynthesis.By similarity

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

GO - Molecular functioni

  1. precorrin-2 dehydrogenase activity Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: PomBase

GO - Biological processi

  1. heme biosynthetic process Source: PomBase
  2. methionine biosynthetic process Source: PomBase
  3. siroheme biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Gene namesi
ORF Names:SPCC1739.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC1739.06c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable uroporphyrinogen-III C-methyltransferasePRO_0000150386Add
BLAST

Proteomic databases

MaxQBiO74468.

Interactioni

Protein-protein interaction databases

BioGridi275519. 24 interactions.
STRINGi4896.SPCC1739.06c-1.

Structurei

3D structure databases

ProteinModelPortaliO74468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 155Poly-Val

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000194244.
InParanoidiO74468.
KOiK00589.
OMAiFIARKFP.
OrthoDBiEOG7WHHP1.
PhylomeDBiO74468.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR006367. Sirohaem_synthase_N.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
PIRSFiPIRSF036555. SUMT_yeast. 1 hit.
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEiPS00840. SUMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74468-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVSWSLKDA VVVVVGSGKN AYRRVNLCLS ENSSKIFWFC RSSADGGFDV
60 70 80 90 100
GHLQLDAKKS DAIEILPISE FDPVRSLTTL GKEETDFLVD AVFVSESNHH
110 120 130 140 150
EKEILHRTCK RYRIPLNIID NPSLCSFTLP ATWSEPPLQI SLSTSSNGCR
160 170 180 190 200
LAQRLLRHVV SSLPSGMPEA IERFGRVRAI TKTPEKKQWI NHVSDFWPLE
210 220 230 240 250
KLVRMTEDDL LAIVSDNFSL PLSSSQSSSL ANSYESLSTT LDKPSLTLDP
260 270 280 290 300
EAFPTHKRGS IALIGSGPGS PDLLTVAARK AIMKADYVLA DKLVPEAVLQ
310 320 330 340 350
LIPRHTPLFI ARKFPGNADK AQDELHQVAF DALSRGDYVV RLKQGDPYIY
360 370 380 390 400
GRGGEEYLFF TQHGYVPTVI PGISSALMAP ISAGIPVTHR GVADQFLVCT
410 420 430 440 450
GTGQKGSMPK IPSFVPTQTT VFLMALHRLE ILVQALIESG WPRVLPVCIA
460 470 480 490
ERVSCPDQRF IFSTLEDVVE EYNKYESLPP GLLITGYSCN TLRNTA
Length:496
Mass (Da):54,712
Last modified:November 1, 1998 - v1
Checksum:i296D3CD7B9C1536E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301F → L in BAA13785. (PubMed:9501991)Curated
Sequence conflicti343 – 3431K → E(PubMed:9501991)Curated
Sequence conflicti345 – 3451G → S(PubMed:9501991)Curated
Sequence conflicti379 – 3791A → P in BAA13785. (PubMed:9501991)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA20780.1.
D89123 mRNA. Translation: BAA13785.1.
AB009602 mRNA. Translation: BAA23999.1.
PIRiT41114.
T42365.
T43302.
RefSeqiNP_588414.1. NM_001023405.2.

Genome annotation databases

EnsemblFungiiSPCC1739.06c.1; SPCC1739.06c.1:pep; SPCC1739.06c.
GeneIDi2538945.
KEGGispo:SPCC1739.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA20780.1 .
D89123 mRNA. Translation: BAA13785.1 .
AB009602 mRNA. Translation: BAA23999.1 .
PIRi T41114.
T42365.
T43302.
RefSeqi NP_588414.1. NM_001023405.2.

3D structure databases

ProteinModelPortali O74468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275519. 24 interactions.
STRINGi 4896.SPCC1739.06c-1.

Proteomic databases

MaxQBi O74468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC1739.06c.1 ; SPCC1739.06c.1:pep ; SPCC1739.06c .
GeneIDi 2538945.
KEGGi spo:SPCC1739.06c.

Organism-specific databases

PomBasei SPCC1739.06c.

Phylogenomic databases

eggNOGi COG0007.
HOGENOMi HOG000194244.
InParanoidi O74468.
KOi K00589.
OMAi FIARKFP.
OrthoDBi EOG7WHHP1.
PhylomeDBi O74468.

Miscellaneous databases

NextBioi 20800120.
PROi O74468.

Family and domain databases

Gene3Di 3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR016040. NAD(P)-bd_dom.
IPR006367. Sirohaem_synthase_N.
IPR012066. SUMT_yeast.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view ]
Pfami PF13241. NAD_binding_7. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036555. SUMT_yeast. 1 hit.
SUPFAMi SSF53790. SSF53790. 1 hit.
TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEi PS00840. SUMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 246-496.
    Strain: PR745.
  3. "S.pombe MET1 homolog."
    Kawamukai M.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 407-496.

Entry informationi

Entry nameiSUMT_SCHPO
AccessioniPrimary (citable) accession number: O74468
Secondary accession number(s): P78775, Q9URL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3