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Protein

Probable uroporphyrinogen-III C-methyltransferase

Gene

SPCC1739.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Siroheme synthase involved in methionine biosynthesis.By similarity

Catalytic activityi

2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Gene namesi
ORF Names:SPCC1739.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.06c
PomBaseiSPCC1739.06c

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001503861 – 496Probable uroporphyrinogen-III C-methyltransferaseAdd BLAST496

Proteomic databases

MaxQBiO74468
PaxDbiO74468
PRIDEiO74468

Interactioni

Protein-protein interaction databases

BioGridi275519, 25 interactors
STRINGi4896.SPCC1739.06c.1

Structurei

3D structure databases

ProteinModelPortaliO74468
SMRiO74468
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 15Poly-Val5

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

HOGENOMiHOG000194244
InParanoidiO74468
KOiK00589
OMAiQVSEYWP
OrthoDBiEOG092C3Q6X
PhylomeDBiO74468

Family and domain databases

CDDicd11642 SUMT, 1 hit
Gene3Di3.30.950.10, 1 hit
3.40.1010.10, 1 hit
InterProiView protein in InterPro
IPR000878 4pyrrol_Mease
IPR035996 4pyrrol_Methylase_sf
IPR014777 4pyrrole_Mease_sub1
IPR014776 4pyrrole_Mease_sub2
IPR006366 CobA/CysG_C
IPR012066 Met1_fungi
IPR003043 Uropor_MeTrfase_CS
PfamiView protein in Pfam
PF00590 TP_methylase, 1 hit
PIRSFiPIRSF036555 SUMT_yeast, 1 hit
SUPFAMiSSF53790 SSF53790, 1 hit
TIGRFAMsiTIGR01469 cobA_cysG_Cterm, 1 hit
PROSITEiView protein in PROSITE
PS00840 SUMT_2, 1 hit

Sequencei

Sequence statusi: Complete.

O74468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVSWSLKDA VVVVVGSGKN AYRRVNLCLS ENSSKIFWFC RSSADGGFDV
60 70 80 90 100
GHLQLDAKKS DAIEILPISE FDPVRSLTTL GKEETDFLVD AVFVSESNHH
110 120 130 140 150
EKEILHRTCK RYRIPLNIID NPSLCSFTLP ATWSEPPLQI SLSTSSNGCR
160 170 180 190 200
LAQRLLRHVV SSLPSGMPEA IERFGRVRAI TKTPEKKQWI NHVSDFWPLE
210 220 230 240 250
KLVRMTEDDL LAIVSDNFSL PLSSSQSSSL ANSYESLSTT LDKPSLTLDP
260 270 280 290 300
EAFPTHKRGS IALIGSGPGS PDLLTVAARK AIMKADYVLA DKLVPEAVLQ
310 320 330 340 350
LIPRHTPLFI ARKFPGNADK AQDELHQVAF DALSRGDYVV RLKQGDPYIY
360 370 380 390 400
GRGGEEYLFF TQHGYVPTVI PGISSALMAP ISAGIPVTHR GVADQFLVCT
410 420 430 440 450
GTGQKGSMPK IPSFVPTQTT VFLMALHRLE ILVQALIESG WPRVLPVCIA
460 470 480 490
ERVSCPDQRF IFSTLEDVVE EYNKYESLPP GLLITGYSCN TLRNTA
Length:496
Mass (Da):54,712
Last modified:November 1, 1998 - v1
Checksum:i296D3CD7B9C1536E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330F → L in BAA13785 (PubMed:9501991).Curated1
Sequence conflicti343K → E (PubMed:9501991).Curated1
Sequence conflicti345G → S (PubMed:9501991).Curated1
Sequence conflicti379A → P in BAA13785 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20780.1
D89123 mRNA Translation: BAA13785.1
AB009602 mRNA Translation: BAA23999.1
PIRiT41114
T42365
T43302
RefSeqiNP_588414.1, NM_001023405.2

Genome annotation databases

EnsemblFungiiSPCC1739.06c.1; SPCC1739.06c.1:pep; SPCC1739.06c
GeneIDi2538945
KEGGispo:SPCC1739.06c

Similar proteinsi

Entry informationi

Entry nameiSUMT_SCHPO
AccessioniPrimary (citable) accession number: O74468
Secondary accession number(s): P78775, Q9URL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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