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Protein

Serine/threonine-protein kinase pef1

Gene

pef1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  • signal transduction Source: PomBase
  • traversing start control point of mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase pef1 (EC:2.7.11.22)
Alternative name(s):
Cyclin-dependent kinase pef1
PHO85 homolog
Gene namesi
Name:pef1
ORF Names:SPCC16C4.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.11.
PomBaseiSPCC16C4.11. pef1.

Subcellular locationi

GO - Cellular componenti

  • ascospore-type prospore Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Serine/threonine-protein kinase pef1PRO_0000086505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphothreonineBy similarity
Modified residuei14 – 141PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74456.
PRIDEiO74456.

Interactioni

Subunit structurei

Interacts with the pas1 cyclin.

Protein-protein interaction databases

BioGridi275932. 432 interactions.
MINTiMINT-4679215.

Structurei

3D structure databases

ProteinModelPortaliO74456.
SMRiO74456. Positions 15-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 285283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiO74456.
KOiK06655.
OMAiTLYDVIH.
OrthoDBiEOG7K3TWD.
PhylomeDBiO74456.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYQRLEKLG EGTYAHVYKG QNRVTGEIVA LKVIRIDADE GTPSTAIREI
60 70 80 90 100
SLMKELRHPN IMSLSDVLQT ENKLMLVFEY MEKDLKKYMD TYGNQGALPP
110 120 130 140 150
SQVKNFTQQL LKGISFCHEN RVLHRDLKPQ NLLINSRGEL KLADFGLARS
160 170 180 190 200
IGIPVNTFSN EVVTLWYRAP DVLLGSRVYS TSIDIWSVGC IMAEMATGRP
210 220 230 240 250
LFAGSNNEDQ LLKIFRLLGT PTEQSWPGIS LLPEYKPTFP IYKAQDLAYL
260 270 280
FPTFDPLGLD LLRRMLRLQP ELRTTGQDAL QHAWFLTA
Length:288
Mass (Da):32,737
Last modified:January 1, 1999 - v2
Checksum:i7A3077D33F40A8FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20750.1.
AB045127 Genomic DNA. Translation: BAB16402.1.
PIRiT41101.
RefSeqiNP_587921.1. NM_001022912.1.

Genome annotation databases

EnsemblFungiiSPCC16C4.11.1; SPCC16C4.11.1:pep; SPCC16C4.11.
GeneIDi2539366.
KEGGispo:SPCC16C4.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20750.1.
AB045127 Genomic DNA. Translation: BAB16402.1.
PIRiT41101.
RefSeqiNP_587921.1. NM_001022912.1.

3D structure databases

ProteinModelPortaliO74456.
SMRiO74456. Positions 15-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275932. 432 interactions.
MINTiMINT-4679215.

Proteomic databases

MaxQBiO74456.
PRIDEiO74456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC16C4.11.1; SPCC16C4.11.1:pep; SPCC16C4.11.
GeneIDi2539366.
KEGGispo:SPCC16C4.11.

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.11.
PomBaseiSPCC16C4.11. pef1.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiO74456.
KOiK06655.
OMAiTLYDVIH.
OrthoDBiEOG7K3TWD.
PhylomeDBiO74456.

Enzyme and pathway databases

BRENDAi2.7.11.22. 5613.

Miscellaneous databases

NextBioi20800531.
PROiO74456.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A pcl-like cyclin activates the Res2p-Cdc10p cell cycle 'start' transcriptional factor complex in fission yeast."
    Tanaka K., Okayama H.
    Mol. Biol. Cell 11:2845-2862(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPEF1_SCHPO
AccessioniPrimary (citable) accession number: O74456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 1, 1999
Last modified: July 22, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.