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O74456 (PEF1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase pef1

EC=2.7.11.22
Alternative name(s):
Cyclin-dependent kinase pef1
PHO85 homolog
Gene names
Name:pef1
ORF Names:SPCC16C4.11
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with the pas1 cyclin.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Serine/threonine-protein kinase pef1
PRO_0000086505

Regions

Domain3 – 285283Protein kinase
Nucleotide binding9 – 179ATP By similarity

Sites

Active site1261Proton acceptor By similarity
Binding site321ATP By similarity

Amino acid modifications

Modified residue131Phosphothreonine By similarity
Modified residue141Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
O74456 [UniParc].

Last modified January 1, 1999. Version 2.
Checksum: 7A3077D33F40A8FA

FASTA28832,737
        10         20         30         40         50         60 
MNYQRLEKLG EGTYAHVYKG QNRVTGEIVA LKVIRIDADE GTPSTAIREI SLMKELRHPN 

        70         80         90        100        110        120 
IMSLSDVLQT ENKLMLVFEY MEKDLKKYMD TYGNQGALPP SQVKNFTQQL LKGISFCHEN 

       130        140        150        160        170        180 
RVLHRDLKPQ NLLINSRGEL KLADFGLARS IGIPVNTFSN EVVTLWYRAP DVLLGSRVYS 

       190        200        210        220        230        240 
TSIDIWSVGC IMAEMATGRP LFAGSNNEDQ LLKIFRLLGT PTEQSWPGIS LLPEYKPTFP 

       250        260        270        280 
IYKAQDLAYL FPTFDPLGLD LLRRMLRLQP ELRTTGQDAL QHAWFLTA 

« Hide

References

« Hide 'large scale' references
[1]"A pcl-like cyclin activates the Res2p-Cdc10p cell cycle 'start' transcriptional factor complex in fission yeast."
Tanaka K., Okayama H.
Mol. Biol. Cell 11:2845-2862(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA20750.1.
AB045127 Genomic DNA. Translation: BAB16402.1.
PIRT41101.
RefSeqNP_587921.1. NM_001022912.1.

3D structure databases

ProteinModelPortalO74456.
SMRO74456. Positions 15-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275932. 429 interactions.
MINTMINT-4679215.
STRING4896.SPCC16C4.11-1.

Proteomic databases

MaxQBO74456.
PRIDEO74456.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC16C4.11.1; SPCC16C4.11.1:pep; SPCC16C4.11.
GeneID2539366.
KEGGspo:SPCC16C4.11.

Organism-specific databases

PomBaseSPCC16C4.11.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK06655.
OMAQVPQNAY.
OrthoDBEOG7K3TWD.
PhylomeDBO74456.

Enzyme and pathway databases

BRENDA2.7.11.22. 5615.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800531.
PROO74456.

Entry information

Entry namePEF1_SCHPO
AccessionPrimary (citable) accession number: O74456
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 1, 1999
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names