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Protein

Serine/threonine-protein kinase pef1

Gene

pef1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  • signal transduction Source: PomBase
  • traversing start control point of mitotic cell cycle Source: PomBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase pef1 (EC:2.7.11.22)
Alternative name(s):
Cyclin-dependent kinase pef1
PHO85 homolog
Gene namesi
Name:pef1
ORF Names:SPCC16C4.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.11
PomBaseiSPCC16C4.11 pef1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865051 – 288Serine/threonine-protein kinase pef1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineBy similarity1
Modified residuei14PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74456
PaxDbiO74456
PRIDEiO74456

Interactioni

Subunit structurei

Interacts with the pas1 cyclin.

Protein-protein interaction databases

BioGridi275932, 436 interactors
STRINGi4896.SPCC16C4.11.1

Structurei

3D structure databases

ProteinModelPortaliO74456
SMRiO74456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 285Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiO74456
KOiK06655
OMAiRHTNETI
OrthoDBiEOG092C2FL8
PhylomeDBiO74456

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

O74456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYQRLEKLG EGTYAHVYKG QNRVTGEIVA LKVIRIDADE GTPSTAIREI
60 70 80 90 100
SLMKELRHPN IMSLSDVLQT ENKLMLVFEY MEKDLKKYMD TYGNQGALPP
110 120 130 140 150
SQVKNFTQQL LKGISFCHEN RVLHRDLKPQ NLLINSRGEL KLADFGLARS
160 170 180 190 200
IGIPVNTFSN EVVTLWYRAP DVLLGSRVYS TSIDIWSVGC IMAEMATGRP
210 220 230 240 250
LFAGSNNEDQ LLKIFRLLGT PTEQSWPGIS LLPEYKPTFP IYKAQDLAYL
260 270 280
FPTFDPLGLD LLRRMLRLQP ELRTTGQDAL QHAWFLTA
Length:288
Mass (Da):32,737
Last modified:January 1, 1999 - v2
Checksum:i7A3077D33F40A8FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20750.1
AB045127 Genomic DNA Translation: BAB16402.1
PIRiT41101
RefSeqiNP_587921.1, NM_001022912.1

Genome annotation databases

EnsemblFungiiSPCC16C4.11.1; SPCC16C4.11.1:pep; SPCC16C4.11
GeneIDi2539366
KEGGispo:SPCC16C4.11

Similar proteinsi

Entry informationi

Entry nameiPEF1_SCHPO
AccessioniPrimary (citable) accession number: O74456
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 1, 1999
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health