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Protein

Probable 6-phosphogluconolactonase

Gene

SPCC16C4.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf1), Probable glucose-6-phosphate 1-dehydrogenase C794.01c (SPCC794.01c), Probable glucose-6-phosphate 1-dehydrogenase C7.13c (SPAC3C7.13c)
  2. Probable 6-phosphogluconolactonase (SPCC16C4.10)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SPBC660.16)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-SPO-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
ORF Names:SPCC16C4.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.10
PomBaseiSPCC16C4.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900861 – 257Probable 6-phosphogluconolactonaseAdd BLAST257

Proteomic databases

MaxQBiO74455
PaxDbiO74455
PRIDEiO74455

Interactioni

Protein-protein interaction databases

BioGridi275499, 179 interactors
STRINGi4896.SPCC16C4.10.1

Structurei

3D structure databases

ProteinModelPortaliO74455
SMRiO74455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000256285
InParanoidiO74455
KOiK01057
OMAiRTIMERP
OrthoDBiEOG092C54SY
PhylomeDBiO74455

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

O74455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYSFSDVS LVAKALGAFV KEKSEASIKR HGVFTLALSG GSLPKVLAEG
60 70 80 90 100
LAQQRGIEFS KWEVFFADER IVPLDDENSN YALCKKLIFD KFEGFDPKKI
110 120 130 140 150
HTINPELLKE NPIDPQNVAD EYEKQLVHVF ANSSTVKVPV FDLLLLGCGP
160 170 180 190 200
DGHTCSLFPD HEVLQEDVAW VAPVTDSPKP PKDRITLTLP VVTHAQAIAF
210 220 230 240 250
VTTGAGKKDI LPIVIEDFTS KLPSALITRN NLTRTSWFVD DEASANLERS

SLKVFPQ
Length:257
Mass (Da):28,351
Last modified:November 1, 1998 - v1
Checksum:iBCA71AB0BA7086DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20749.1
PIRiT41100
RefSeqiNP_587920.1, NM_001022911.2

Genome annotation databases

EnsemblFungiiSPCC16C4.10.1; SPCC16C4.10.1:pep; SPCC16C4.10
GeneIDi2538922
KEGGispo:SPCC16C4.10

Similar proteinsi

Entry informationi

Entry namei6PGL_SCHPO
AccessioniPrimary (citable) accession number: O74455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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