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Protein

Shk1 kinase-binding protein 15

Gene

skb15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Negatively regulates pak1/shk1 kinase activity leading to proper execution of cytoskeletal remodeling and cytokinetic functions.1 Publication
Interacts with pak1/shk1.1 Publication

GO - Molecular functioni

  • protein kinase inhibitor activity Source: PomBase

GO - Biological processi

  • regulation of actin cytoskeleton organization Source: PomBase
  • regulation of microtubule cytoskeleton organization Source: PomBase
  • ribosome biogenesis Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Shk1 kinase-binding protein 15
Gene namesi
Name:skb15
ORF Names:SPCC16C4.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.08c
PomBaseiSPCC16C4.08c skb15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512171 – 341Shk1 kinase-binding protein 15Add BLAST341

Proteomic databases

MaxQBiO74453
PaxDbiO74453
PRIDEiO74453

PTM databases

iPTMnetiO74453

Interactioni

Protein-protein interaction databases

BioGridi275340, 2 interactors
STRINGi4896.SPCC16C4.08c.1

Structurei

3D structure databases

ProteinModelPortaliO74453
SMRiO74453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 70WD 1Add BLAST38
Repeati77 – 114WD 2Add BLAST38
Repeati119 – 157WD 3Add BLAST39
Repeati197 – 234WD 4Add BLAST38
Repeati237 – 274WD 5Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO74453
KOiK14830
OMAiSYEHNLL
OrthoDBiEOG092C3TDN
PhylomeDBiO74453

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR018391 PQQ_beta_propeller_repeat
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00564 PQQ, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

O74453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFVVGTYT HLIYGVDADI ERKKCKPLWL FEAHEGALTA LAVDGIYLAS
60 70 80 90 100
TSSDETIKIF DHTRNVQIAD VSVPTDIANA CIRDMCFTKN HLLACHDNGQ
110 120 130 140 150
ISMWSKGSWL LVHTLKSSSH KGITGIAVHP SEKLALTVGG DGKLRLWDLV
160 170 180 190 200
RGKGGKVLPL STIPESILFL NESSFVIMSR RGIDAFKLDL TSLFSFSSKS
210 220 230 240 250
QLNALCLYQS KLIVGRDNGT VLVLDTSDGK ILHEFTAHKK RVKSVYPVDD
260 270 280 290 300
YLITASSDGS VCIWDKDWNL VIEHNIPEGN RITCMVAMLA DSNSEPKNVE
310 320 330 340
DEAAKRQSLD SETSETSSES ESESEYYSTS KQPPVKRTKH A
Length:341
Mass (Da):37,710
Last modified:November 1, 1998 - v1
Checksum:i08E7A14D5C215BC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122G → C in AAK51600 (PubMed:11389855).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030407 Genomic DNA Translation: AAK51600.1
CU329672 Genomic DNA Translation: CAA20747.1
PIRiT41098
RefSeqiNP_587918.1, NM_001022909.2

Genome annotation databases

EnsemblFungiiSPCC16C4.08c.1; SPCC16C4.08c.1:pep; SPCC16C4.08c
GeneIDi2538757
KEGGispo:SPCC16C4.08c

Similar proteinsi

Entry informationi

Entry nameiSKB15_SCHPO
AccessioniPrimary (citable) accession number: O74453
Secondary accession number(s): Q96VR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health