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Protein

Shk1 kinase-binding protein 15

Gene

skb15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Negatively regulates pak1/shk1 kinase activity leading to proper execution of cytoskeletal remodeling and cytokinetic functions.1 Publication
Interacts with pak1/shk1.1 Publication

GO - Molecular functioni

  • protein kinase inhibitor activity Source: PomBase

GO - Biological processi

  • regulation of actin cytoskeleton organization Source: PomBase
  • regulation of microtubule cytoskeleton organization Source: PomBase
  • ribosome biogenesis Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Shk1 kinase-binding protein 15
Gene namesi
Name:skb15
ORF Names:SPCC16C4.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.08c.
PomBaseiSPCC16C4.08c. skb15.

Subcellular locationi

GO - Cellular componenti

  • nucleolar preribosome Source: PomBase
  • nucleus Source: PomBase
  • protein complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Shk1 kinase-binding protein 15PRO_0000051217Add
BLAST

Proteomic databases

MaxQBiO74453.

Interactioni

Protein-protein interaction databases

BioGridi275340. 2 interactions.
MINTiMINT-4679172.

Structurei

3D structure databases

ProteinModelPortaliO74453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati33 – 7038WD 1Add
BLAST
Repeati77 – 11438WD 2Add
BLAST
Repeati119 – 15739WD 3Add
BLAST
Repeati197 – 23438WD 4Add
BLAST
Repeati237 – 27438WD 5Add
BLAST

Sequence similaritiesi

Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO74453.
KOiK14830.
OMAiSEFKAHE.
OrthoDBiEOG092C3TDN.
PhylomeDBiO74453.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR018391. PQQ_beta_propeller_repeat.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00564. PQQ. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFVVGTYT HLIYGVDADI ERKKCKPLWL FEAHEGALTA LAVDGIYLAS
60 70 80 90 100
TSSDETIKIF DHTRNVQIAD VSVPTDIANA CIRDMCFTKN HLLACHDNGQ
110 120 130 140 150
ISMWSKGSWL LVHTLKSSSH KGITGIAVHP SEKLALTVGG DGKLRLWDLV
160 170 180 190 200
RGKGGKVLPL STIPESILFL NESSFVIMSR RGIDAFKLDL TSLFSFSSKS
210 220 230 240 250
QLNALCLYQS KLIVGRDNGT VLVLDTSDGK ILHEFTAHKK RVKSVYPVDD
260 270 280 290 300
YLITASSDGS VCIWDKDWNL VIEHNIPEGN RITCMVAMLA DSNSEPKNVE
310 320 330 340
DEAAKRQSLD SETSETSSES ESESEYYSTS KQPPVKRTKH A
Length:341
Mass (Da):37,710
Last modified:November 1, 1998 - v1
Checksum:i08E7A14D5C215BC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221G → C in AAK51600 (PubMed:11389855).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030407 Genomic DNA. Translation: AAK51600.1.
CU329672 Genomic DNA. Translation: CAA20747.1.
PIRiT41098.
RefSeqiNP_587918.1. NM_001022909.2.

Genome annotation databases

EnsemblFungiiSPCC16C4.08c.1; SPCC16C4.08c.1:pep; SPCC16C4.08c.
GeneIDi2538757.
KEGGispo:SPCC16C4.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030407 Genomic DNA. Translation: AAK51600.1.
CU329672 Genomic DNA. Translation: CAA20747.1.
PIRiT41098.
RefSeqiNP_587918.1. NM_001022909.2.

3D structure databases

ProteinModelPortaliO74453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275340. 2 interactions.
MINTiMINT-4679172.

Proteomic databases

MaxQBiO74453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC16C4.08c.1; SPCC16C4.08c.1:pep; SPCC16C4.08c.
GeneIDi2538757.
KEGGispo:SPCC16C4.08c.

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.08c.
PomBaseiSPCC16C4.08c. skb15.

Phylogenomic databases

InParanoidiO74453.
KOiK14830.
OMAiSEFKAHE.
OrthoDBiEOG092C3TDN.
PhylomeDBiO74453.

Miscellaneous databases

PROiO74453.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR018391. PQQ_beta_propeller_repeat.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00564. PQQ. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSKB15_SCHPO
AccessioniPrimary (citable) accession number: O74453
Secondary accession number(s): Q96VR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.