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Protein

Peptidyl-prolyl cis-trans isomerase pin1

Gene

pin1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Has a role in the G1/S stage transition of mitosis where it is involved in the dephosphorylation of cdc25 and wee1.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase pin1 (EC:5.2.1.8)
Short name:
PPIase pin1
Gene namesi
Name:pin1
ORF Names:SPCC16C4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.03.
PomBaseiSPCC16C4.03. pin1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934431 – 175Peptidyl-prolyl cis-trans isomerase pin1Add BLAST175

Proteomic databases

MaxQBiO74448.
PRIDEiO74448.

PTM databases

iPTMnetiO74448.

Interactioni

Protein-protein interaction databases

BioGridi275788. 3 interactors.
MINTiMINT-4679132.
STRINGi4896.SPCC16C4.03.1.

Structurei

3D structure databases

ProteinModelPortaliO74448.
SMRiO74448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 38WWPROSITE-ProRule annotationAdd BLAST35
Domaini64 – 175PpiCPROSITE-ProRule annotationAdd BLAST112

Phylogenomic databases

HOGENOMiHOG000275331.
InParanoidiO74448.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG092C4TRA.
PhylomeDBiO74448.

Family and domain databases

CDDicd00201. WW. 1 hit.
InterProiView protein in InterPro
IPR000297. PPIase_PpiC.
IPR001202. WW_dom.
IPR036020. WW_dom_sf.
PfamiView protein in Pfam
PF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
SMARTiView protein in SMART
SM00456. WW. 1 hit.
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS50198. PPIC_PPIASE_2. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O74448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTGLPKPW IVKISRSRNR PYFFNTETHE SLWEPPAATD MAALKKFIAN
60 70 80 90 100
ELQESVTPTE ASNSPKIRAS HLLVKHRESR RPSSWKEEHI TRSKEEARKL
110 120 130 140 150
AEHYEQLLKS GSVSMHDLAM KESDCSSARR GGELGEFGRD EMQKPFEDAA
160 170
FALKPGEISG VVETSSGFHI IQRHA
Length:175
Mass (Da):19,773
Last modified:November 1, 1998 - v1
Checksum:iABA637835471BD25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20742.1.
PIRiT41093.
RefSeqiNP_587913.1. NM_001022904.2.

Genome annotation databases

EnsemblFungiiSPCC16C4.03.1; SPCC16C4.03.1:pep; SPCC16C4.03.
GeneIDi2539218.
KEGGispo:SPCC16C4.03.

Entry informationi

Entry nameiPIN1_SCHPO
AccessioniPrimary (citable) accession number: O74448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names