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Protein

Peptidyl-prolyl cis-trans isomerase pin1

Gene

pin1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has a role in the G1/S stage transition of mitosis where it is involved in the dephosphorylation of cdc25 and wee1.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase pin1 (EC:5.2.1.8)
Short name:
PPIase pin1
Gene namesi
Name:pin1
ORF Names:SPCC16C4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.03.
PomBaseiSPCC16C4.03. pin1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Peptidyl-prolyl cis-trans isomerase pin1PRO_0000193443Add
BLAST

Proteomic databases

MaxQBiO74448.

Interactioni

Protein-protein interaction databases

BioGridi275788. 3 interactions.
MINTiMINT-4679132.

Structurei

3D structure databases

ProteinModelPortaliO74448.
SMRiO74448. Positions 66-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 3835WWPROSITE-ProRule annotationAdd
BLAST
Domaini64 – 175112PpiCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PpiC domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000275331.
InParanoidiO74448.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG7HHX51.
PhylomeDBiO74448.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTGLPKPW IVKISRSRNR PYFFNTETHE SLWEPPAATD MAALKKFIAN
60 70 80 90 100
ELQESVTPTE ASNSPKIRAS HLLVKHRESR RPSSWKEEHI TRSKEEARKL
110 120 130 140 150
AEHYEQLLKS GSVSMHDLAM KESDCSSARR GGELGEFGRD EMQKPFEDAA
160 170
FALKPGEISG VVETSSGFHI IQRHA
Length:175
Mass (Da):19,773
Last modified:November 1, 1998 - v1
Checksum:iABA637835471BD25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20742.1.
PIRiT41093.
RefSeqiNP_587913.1. NM_001022904.2.

Genome annotation databases

EnsemblFungiiSPCC16C4.03.1; SPCC16C4.03.1:pep; SPCC16C4.03.
GeneIDi2539218.
KEGGispo:SPCC16C4.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20742.1.
PIRiT41093.
RefSeqiNP_587913.1. NM_001022904.2.

3D structure databases

ProteinModelPortaliO74448.
SMRiO74448. Positions 66-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275788. 3 interactions.
MINTiMINT-4679132.

Proteomic databases

MaxQBiO74448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC16C4.03.1; SPCC16C4.03.1:pep; SPCC16C4.03.
GeneIDi2539218.
KEGGispo:SPCC16C4.03.

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.03.
PomBaseiSPCC16C4.03. pin1.

Phylogenomic databases

HOGENOMiHOG000275331.
InParanoidiO74448.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG7HHX51.
PhylomeDBiO74448.

Miscellaneous databases

NextBioi20800388.
PROiO74448.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50198. PPIC_PPIASE_2. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe."
    Huang H.-K., Forsburg S.L., John U.P., O'Connell M.J., Hunter T.
    J. Cell Sci. 114:3779-3788(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPIN1_SCHPO
AccessioniPrimary (citable) accession number: O74448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.