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O74442

- UBP16_SCHPO

UniProt

O74442 - UBP16_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 16

Gene

ubp16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei134 – 1341NucleophilePROSITE-ProRule annotation
    Active sitei388 – 3881Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A66.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 16
    Ubiquitin thioesterase 16
    Ubiquitin-specific-processing protease 16
    Gene namesi
    Name:ubp16
    ORF Names:SPCC1682.12c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC1682.12c.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Probable ubiquitin carboxyl-terminal hydrolase 16PRO_0000248399Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611Phosphoserine1 Publication
    Modified residuei64 – 641Phosphothreonine1 Publication
    Modified residuei65 – 651Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO74442.

    Interactioni

    Protein-protein interaction databases

    BioGridi275521. 26 interactions.
    MINTiMINT-4679081.
    STRINGi4896.SPCC1682.12c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO74442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 429305USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    KOiK11855.
    OMAiIVCALEM.
    OrthoDBiEOG74BK2K.
    PhylomeDBiO74442.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74442-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLATLQGQS LDFAVKHSLD DLLKNPVRFR PAVVSSPSVP EGTYTVLNNP    50
    KQSTVSRKSF SAPTSPTRNK RSGSSSQEYK KSSGTRGDGA NDFVDEDPAF 100
    IPPARILFPE EKLSMEWDNI MPNAPGLVNL GNTCFMNSVL QLMTQTPPLV 150
    QYLLSGQHSL SCRMNACVLC RMEQHVARAY PNKGTKRASA FKPSGIQSML 200
    KVISSHFRPY RQEDAHEFMR YLVDAWQKSC LQNHKNLDHP SRETSVVHRI 250
    FGGYLRQQIL CSVCKKPSNT YQALLDLSVD AKGSSLADSL KHFVHAEKLT 300
    KQNKYRCENC KQLVDASKQM TIYRAPNILT IHFKRFTFNG FQSSKISKQI 350
    SYPESFNLGP YMSDPNCSCW YELIGVLVHA GGSTRSGHYY SFCKSSNGVW 400
    LKFDDDFVSN SSIDRVLNQQ AYILQYKRKS TSSSKHKLNT ENTVTKTSNK 450
    KRRKISF 457
    Length:457
    Mass (Da):51,582
    Last modified:November 1, 1998 - v1
    Checksum:i56AADB2AA996EFF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA20678.1.
    PIRiT41069.
    RefSeqiNP_587805.1. NM_001022798.2.

    Genome annotation databases

    EnsemblFungiiSPCC1682.12c.1; SPCC1682.12c.1:pep; SPCC1682.12c.
    GeneIDi2538947.
    KEGGispo:SPCC1682.12c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA20678.1 .
    PIRi T41069.
    RefSeqi NP_587805.1. NM_001022798.2.

    3D structure databases

    ProteinModelPortali O74442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275521. 26 interactions.
    MINTi MINT-4679081.
    STRINGi 4896.SPCC1682.12c-1.

    Protein family/group databases

    MEROPSi C19.A66.

    Proteomic databases

    MaxQBi O74442.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC1682.12c.1 ; SPCC1682.12c.1:pep ; SPCC1682.12c .
    GeneIDi 2538947.
    KEGGi spo:SPCC1682.12c.

    Organism-specific databases

    PomBasei SPCC1682.12c.

    Phylogenomic databases

    eggNOGi COG5077.
    KOi K11855.
    OMAi IVCALEM.
    OrthoDBi EOG74BK2K.
    PhylomeDBi O74442.

    Miscellaneous databases

    NextBioi 20800122.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; THR-64 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiUBP16_SCHPO
    AccessioniPrimary (citable) accession number: O74442
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3