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Protein

Probable ubiquitin carboxyl-terminal hydrolase 16

Gene

ubp16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134NucleophilePROSITE-ProRule annotation1
Active sitei388Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.A66

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene namesi
Name:ubp16
ORF Names:SPCC1682.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1682.12c
PomBaseiSPCC1682.12c ubp16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483991 – 457Probable ubiquitin carboxyl-terminal hydrolase 16Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Phosphoserine1 Publication1
Modified residuei64Phosphothreonine1 Publication1
Modified residuei65Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74442
PaxDbiO74442
PRIDEiO74442

PTM databases

iPTMnetiO74442

Interactioni

Protein-protein interaction databases

BioGridi275521, 25 interactors
STRINGi4896.SPCC1682.12c.1

Structurei

3D structure databases

ProteinModelPortaliO74442
SMRiO74442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 429USPAdd BLAST305

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

InParanoidiO74442
KOiK11855
OMAiADIDNIF
OrthoDBiEOG092C5R71
PhylomeDBiO74442

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

O74442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLATLQGQS LDFAVKHSLD DLLKNPVRFR PAVVSSPSVP EGTYTVLNNP
60 70 80 90 100
KQSTVSRKSF SAPTSPTRNK RSGSSSQEYK KSSGTRGDGA NDFVDEDPAF
110 120 130 140 150
IPPARILFPE EKLSMEWDNI MPNAPGLVNL GNTCFMNSVL QLMTQTPPLV
160 170 180 190 200
QYLLSGQHSL SCRMNACVLC RMEQHVARAY PNKGTKRASA FKPSGIQSML
210 220 230 240 250
KVISSHFRPY RQEDAHEFMR YLVDAWQKSC LQNHKNLDHP SRETSVVHRI
260 270 280 290 300
FGGYLRQQIL CSVCKKPSNT YQALLDLSVD AKGSSLADSL KHFVHAEKLT
310 320 330 340 350
KQNKYRCENC KQLVDASKQM TIYRAPNILT IHFKRFTFNG FQSSKISKQI
360 370 380 390 400
SYPESFNLGP YMSDPNCSCW YELIGVLVHA GGSTRSGHYY SFCKSSNGVW
410 420 430 440 450
LKFDDDFVSN SSIDRVLNQQ AYILQYKRKS TSSSKHKLNT ENTVTKTSNK

KRRKISF
Length:457
Mass (Da):51,582
Last modified:November 1, 1998 - v1
Checksum:i56AADB2AA996EFF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20678.1
PIRiT41069
RefSeqiNP_587805.1, NM_001022798.2

Genome annotation databases

EnsemblFungiiSPCC1682.12c.1; SPCC1682.12c.1:pep; SPCC1682.12c
GeneIDi2538947
KEGGispo:SPCC1682.12c

Similar proteinsi

Entry informationi

Entry nameiUBP16_SCHPO
AccessioniPrimary (citable) accession number: O74442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health