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O74442 (UBP16_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase 16

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene names
Name:ubp16
ORF Names:SPCC1682.12c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Probable ubiquitin carboxyl-terminal hydrolase 16
PRO_0000248399

Regions

Domain125 – 429305USP

Sites

Active site1341Nucleophile By similarity
Active site3881Proton acceptor By similarity

Amino acid modifications

Modified residue611Phosphoserine Ref.2
Modified residue641Phosphothreonine Ref.2
Modified residue651Phosphoserine Ref.2

Sequences

Sequence LengthMass (Da)Tools
O74442 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 56AADB2AA996EFF3

FASTA45751,582
        10         20         30         40         50         60 
MSLATLQGQS LDFAVKHSLD DLLKNPVRFR PAVVSSPSVP EGTYTVLNNP KQSTVSRKSF 

        70         80         90        100        110        120 
SAPTSPTRNK RSGSSSQEYK KSSGTRGDGA NDFVDEDPAF IPPARILFPE EKLSMEWDNI 

       130        140        150        160        170        180 
MPNAPGLVNL GNTCFMNSVL QLMTQTPPLV QYLLSGQHSL SCRMNACVLC RMEQHVARAY 

       190        200        210        220        230        240 
PNKGTKRASA FKPSGIQSML KVISSHFRPY RQEDAHEFMR YLVDAWQKSC LQNHKNLDHP 

       250        260        270        280        290        300 
SRETSVVHRI FGGYLRQQIL CSVCKKPSNT YQALLDLSVD AKGSSLADSL KHFVHAEKLT 

       310        320        330        340        350        360 
KQNKYRCENC KQLVDASKQM TIYRAPNILT IHFKRFTFNG FQSSKISKQI SYPESFNLGP 

       370        380        390        400        410        420 
YMSDPNCSCW YELIGVLVHA GGSTRSGHYY SFCKSSNGVW LKFDDDFVSN SSIDRVLNQQ 

       430        440        450 
AYILQYKRKS TSSSKHKLNT ENTVTKTSNK KRRKISF 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; THR-64 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA20678.1.
PIRT41069.
RefSeqNP_587805.1. NM_001022798.2.

3D structure databases

ProteinModelPortalO74442.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275521. 26 interactions.
MINTMINT-4679081.
STRING4896.SPCC1682.12c-1.

Protein family/group databases

MEROPSC19.A66.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1682.12c.1; SPCC1682.12c.1:pep; SPCC1682.12c.
GeneID2538947.
KEGGspo:SPCC1682.12c.

Organism-specific databases

PomBaseSPCC1682.12c.

Phylogenomic databases

eggNOGCOG5077.
KOK11855.
OMAIVCALEM.
OrthoDBEOG74BK2K.
PhylomeDBO74442.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800122.

Entry information

Entry nameUBP16_SCHPO
AccessionPrimary (citable) accession number: O74442
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries