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Protein

26S proteasome regulatory subunit rpn8

Gene

rpn8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiM67.973.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit rpn8
Gene namesi
Name:rpn8
ORF Names:SPCC1682.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1682.10.
PomBaseiSPCC1682.10. rpn8.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • mitotic spindle midzone Source: PomBase
  • nuclear envelope Source: PomBase
  • nucleus Source: PomBase
  • proteasome complex Source: GO_Central
  • proteasome regulatory particle, lid subcomplex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139501 – 32426S proteasome regulatory subunit rpn8Add BLAST324

Proteomic databases

MaxQBiO74440.
PRIDEiO74440.

Interactioni

Protein-protein interaction databases

BioGridi275489. 4 interactors.
IntActiO74440. 1 interactor.
MINTiMINT-4679063.

Structurei

3D structure databases

ProteinModelPortaliO74440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M67A family.Curated
Contains 1 MPN (JAB/Mov34) domain.Curated

Phylogenomic databases

HOGENOMiHOG000209236.
InParanoidiO74440.
KOiK03038.
OMAiRIANIVQ.
OrthoDBiEOG092C3ND9.
PhylomeDBiO74440.

Family and domain databases

CDDicd08062. MPN_RPN7_8. 1 hit.
InterProiIPR000555. JAMM/MPN+_dom.
IPR033858. MPN_RPN7_8.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAVSSETS TIVPQQVIVH PLVLLSAVDS YNRSAKGTKR RVVGILLGQN
60 70 80 90 100
NGDVVNVANS YAIPFEEDEK NASVWFLDHN FMESMNEMFK KINANEKLVG
110 120 130 140 150
WYHTGPQLRP SDLEINNLLK KYIPNPVLVI IDVKPKSVGL PTNAYFAIDE
160 170 180 190 200
IEDDGSKSSR TFVHLPSSIE AEEAEEIGVE HLLRDTRDAS VGTLATRVTQ
210 220 230 240 250
QAQSLQGLGQ RLTEIADYLR KVVDGQLPIN HAILAELQSV FNLLPNIFSG
260 270 280 290 300
PVVSEQALES EAQRAFNVNS NDQLMSIYIS SIVRAVIALH DLLDSLAASK
310 320
AMEQQDIKPT VQNGEVSANA EQKA
Length:324
Mass (Da):35,595
Last modified:November 1, 1998 - v1
Checksum:i538538D1863789E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20676.1.
PIRiT41067.
RefSeqiNP_587803.1. NM_001022796.2.

Genome annotation databases

EnsemblFungiiSPCC1682.10.1; SPCC1682.10.1:pep; SPCC1682.10.
GeneIDi2538912.
KEGGispo:SPCC1682.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20676.1.
PIRiT41067.
RefSeqiNP_587803.1. NM_001022796.2.

3D structure databases

ProteinModelPortaliO74440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275489. 4 interactors.
IntActiO74440. 1 interactor.
MINTiMINT-4679063.

Protein family/group databases

MEROPSiM67.973.

Proteomic databases

MaxQBiO74440.
PRIDEiO74440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1682.10.1; SPCC1682.10.1:pep; SPCC1682.10.
GeneIDi2538912.
KEGGispo:SPCC1682.10.

Organism-specific databases

EuPathDBiFungiDB:SPCC1682.10.
PomBaseiSPCC1682.10. rpn8.

Phylogenomic databases

HOGENOMiHOG000209236.
InParanoidiO74440.
KOiK03038.
OMAiRIANIVQ.
OrthoDBiEOG092C3ND9.
PhylomeDBiO74440.

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO74440.

Family and domain databases

CDDicd08062. MPN_RPN7_8. 1 hit.
InterProiIPR000555. JAMM/MPN+_dom.
IPR033858. MPN_RPN7_8.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPN8_SCHPO
AccessioniPrimary (citable) accession number: O74440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.