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Protein

Probable lipase C1672.09

Gene

SPCC1672.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable lipase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei222 – 2221NucleophileBy similarity
Active sitei389 – 3891Charge relay systemBy similarity
Active sitei415 – 4151Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-SPO-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERischpo-SPCC1672.09. Acidic_Lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipase C1672.09 (EC:3.1.1.-)
Gene namesi
ORF Names:SPCC1672.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1672.09.
PomBaseiSPCC1672.09.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini39 – 467429LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Probable lipase C1672.09PRO_0000312659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661Phosphoserine1 Publication
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO74430.

PTM databases

iPTMnetiO74430.

Interactioni

Protein-protein interaction databases

BioGridi275910. 9 interactions.
MINTiMINT-4678980.

Structurei

3D structure databases

ProteinModelPortaliO74430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000173756.
InParanoidiO74430.
KOiK01052.
OrthoDBiEOG790G8X.
PhylomeDBiO74430.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

O74430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQLPFIQRL KWEEYMALFL GFFFVIFEKL LSCLAFMIHN TLGLFYRSVV
60 70 80 90 100
RNEIKKRSKK RSRSRSVSLQ RAKAIHDAAD IREMCKISGY YVEDHLVRTE
110 120 130 140 150
DDYILCIHRI SKDSPGRIGS PHPKKLPVVY CHHGLLMNSE VWVCNVDPRN
160 170 180 190 200
CLVFDLVNKG YDVWLGNNRG NKYSRQHLRF DSTDKEFWDF SIDDFAQYDI
210 220 230 240 250
PDTIDYILKT SGQTKLTYIG FSQGTAQAFA SLSIHPLLND KINSLIALAP
260 270 280 290 300
AISPKGLHNR VVDAFVKARP SILFFLFGRK SILPSAGFWQ SFLAPKFFDA
310 320 330 340 350
VLAYCLSQLF NWSCQNISSY QRLVSFAHLY SYTSVKCLVH WFQIMRSAEF
360 370 380 390 400
RMYDNDQLGH DYFLKYYKAA KFPTNNIRTP IYLIWGGSDS LVDIQAMLNA
410 420 430 440 450
LPAEVEHVKV DSYEHLDMIW ADTVKDYVIP PVLRRLRDIH HPPEHEENDK
460
ENREIQKNHI APRNKPI
Length:467
Mass (Da):54,381
Last modified:November 1, 1998 - v1
Checksum:i2ED7D0A3F5D86FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20447.1.
PIRiT41053.
RefSeqiNP_587880.1. NM_001022872.2.

Genome annotation databases

EnsemblFungiiSPCC1672.09.1; SPCC1672.09.1:pep; SPCC1672.09.
GeneIDi2539344.
KEGGispo:SPCC1672.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20447.1.
PIRiT41053.
RefSeqiNP_587880.1. NM_001022872.2.

3D structure databases

ProteinModelPortaliO74430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275910. 9 interactions.
MINTiMINT-4678980.

Protein family/group databases

ESTHERischpo-SPCC1672.09. Acidic_Lipase.

PTM databases

iPTMnetiO74430.

Proteomic databases

MaxQBiO74430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1672.09.1; SPCC1672.09.1:pep; SPCC1672.09.
GeneIDi2539344.
KEGGispo:SPCC1672.09.

Organism-specific databases

EuPathDBiFungiDB:SPCC1672.09.
PomBaseiSPCC1672.09.

Phylogenomic databases

HOGENOMiHOG000173756.
InParanoidiO74430.
KOiK01052.
OrthoDBiEOG790G8X.
PhylomeDBiO74430.

Enzyme and pathway databases

ReactomeiR-SPO-192456. Digestion of dietary lipid.

Miscellaneous databases

NextBioi20800509.
PROiO74430.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTGCE1_SCHPO
AccessioniPrimary (citable) accession number: O74430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1998
Last modified: February 17, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.