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Protein

Uridine kinase

Gene

urk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway.By similarity

Catalytic activityi

ATP + uridine = ADP + UMP.
ATP + cytidine = ADP + CMP.

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (urk1), Putative uridine kinase C227.14 (SPAC227.14)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (urk1), Putative uridine kinase C227.14 (SPAC227.14)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinase (EC:2.7.1.48)
Alternative name(s):
Uridine monophosphokinase
Gene namesi
Name:urk1
ORF Names:SPCC162.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC162.11c.
PomBaseiSPCC162.11c.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Uridine kinasePRO_0000311758Add
BLAST

Proteomic databases

MaxQBiO74427.

Interactioni

Protein-protein interaction databases

BioGridi275520. 236 interactions.
MINTiMINT-4678947.

Structurei

3D structure databases

ProteinModelPortaliO74427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000262757.
InParanoidiO74427.
KOiK00876.
OMAiMDCFYKI.
OrthoDBiEOG7BKD5H.
PhylomeDBiO74427.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
PF14681. UPRTase. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

O74427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAFERYSS NPTYEPPWRK VRFIGIAGPS GSGKTSVAQL IVKALNLPHV
60 70 80 90 100
VILSLDSFYK SLNAEQKKRA FNNDYDFDSP EAIDWDLLFV KLLELKQGRK
110 120 130 140 150
VDIPIYSFNE HNRLPETNTL FGASIIILEG IFALYDEKIR SLLDVSVFLD
160 170 180 190 200
TDSDVCLSRR LNRDINYRGR DIVGVLEQYN KFVKPSYENF VRRQLSYTDL
210 220 230 240 250
IVPRGRDNKL AIDMVINFIR RTLSIQSETH VKNIDSLQQI VPTIPHLPLN
260 270 280 290 300
LVQLKITPEI SAIRTILINK NTHPDDLQFF LSRIGTMLMN LAGDSLAYEK
310 320 330 340 350
KTITLHNGNQ WEGLQMAKEL CGVSVLRSGG TLETALCRQF PTVCLGKILV
360 370 380 390 400
QINKVTQEPT LHYHKLPRGI ATMNVVLMAS HLTTHADVLM ATQILVDFGV
410 420 430 440 450
PEENIIIVVY VCYSESIKAL AYIFPKVTIV TAFLESVAEP VVGRLDIEKV

YYGC
Length:454
Mass (Da):51,390
Last modified:November 1, 1998 - v1
Checksum:i80EC445495854654
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19591.1.
PIRiT41020.
RefSeqiNP_588233.1. NM_001023223.2.

Genome annotation databases

EnsemblFungiiSPCC162.11c.1; SPCC162.11c.1:pep; SPCC162.11c.
GeneIDi2538946.
KEGGispo:SPCC162.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19591.1.
PIRiT41020.
RefSeqiNP_588233.1. NM_001023223.2.

3D structure databases

ProteinModelPortaliO74427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275520. 236 interactions.
MINTiMINT-4678947.

Proteomic databases

MaxQBiO74427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC162.11c.1; SPCC162.11c.1:pep; SPCC162.11c.
GeneIDi2538946.
KEGGispo:SPCC162.11c.

Organism-specific databases

EuPathDBiFungiDB:SPCC162.11c.
PomBaseiSPCC162.11c.

Phylogenomic databases

HOGENOMiHOG000262757.
InParanoidiO74427.
KOiK00876.
OMAiMDCFYKI.
OrthoDBiEOG7BKD5H.
PhylomeDBiO74427.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Miscellaneous databases

PROiO74427.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR000764. Uridine_kinase-like.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
PF14681. UPRTase. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiURK1_SCHPO
AccessioniPrimary (citable) accession number: O74427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.