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Protein

Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Gene

coq3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.UniRule annotation
S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651S-adenosyl-L-methionineUniRule annotation
Binding sitei88 – 881S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei109 – 1091S-adenosyl-L-methionineUniRule annotation
Binding sitei154 – 1541S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-SPO-2142789. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferase, mitochondrialUniRule annotation
Alternative name(s):
3-demethylubiquinol 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Polyprenyldihydroxybenzoate methyltransferaseUniRule annotation (EC:2.1.1.114UniRule annotation)
Gene namesi
Name:coq3UniRule annotation
ORF Names:SPCC162.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC162.05.
PomBaseiSPCC162.05. coq3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Leads to respiration deficiency.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 274244Ubiquinone biosynthesis O-methyltransferase, mitochondrialPRO_0000035931Add
BLAST

Proteomic databases

MaxQBiO74421.

PTM databases

SwissPalmiO74421.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9.UniRule annotation

Protein-protein interaction databases

MINTiMINT-4678908.

Structurei

3D structure databases

ProteinModelPortaliO74421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000278065.
InParanoidiO74421.
KOiK00568.
OMAiVIRACHR.
OrthoDBiEOG092C3VU8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSMNILNKV KNVKSYTRLV RQGFLSQQRN HSVSVNEVDH FNELAKTWWD
60 70 80 90 100
WDGGSRLLHL MNSTRLDFMT EVFRERNCFS GKKILDIGCG GGILSESMAR
110 120 130 140 150
LGASVTAVDA SPMAIEVAKK HASLDPVLNG RLEYIHGSVE GSQLPTTFDV
160 170 180 190 200
VTCMEVLEHV EQPRDFLFSL MEKVKPNGRL VLSTISRTLL ARLLTITLAE
210 220 230 240 250
HVLRIVPVGT HTFEKFIRAD ELSNFLKEQN WIINDIRGVC YNPLKQQWTL
260 270
DKPGSSGLGL SCNYFLSAQK PMSA
Length:274
Mass (Da):30,827
Last modified:July 11, 2012 - v2
Checksum:i152CEC61E9F02797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19585.2.
PIRiT41026.
RefSeqiNP_588239.2. NM_001023229.2.

Genome annotation databases

EnsemblFungiiSPCC162.05.1; SPCC162.05.1:pep; SPCC162.05.
GeneIDi2538771.
KEGGispo:SPCC162.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19585.2.
PIRiT41026.
RefSeqiNP_588239.2. NM_001023229.2.

3D structure databases

ProteinModelPortaliO74421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4678908.

PTM databases

SwissPalmiO74421.

Proteomic databases

MaxQBiO74421.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC162.05.1; SPCC162.05.1:pep; SPCC162.05.
GeneIDi2538771.
KEGGispo:SPCC162.05.

Organism-specific databases

EuPathDBiFungiDB:SPCC162.05.
PomBaseiSPCC162.05. coq3.

Phylogenomic databases

HOGENOMiHOG000278065.
InParanoidiO74421.
KOiK00568.
OMAiVIRACHR.
OrthoDBiEOG092C3VU8.

Enzyme and pathway databases

UniPathwayiUPA00232.
ReactomeiR-SPO-2142789. Ubiquinol biosynthesis.

Miscellaneous databases

PROiO74421.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOQ3_SCHPO
AccessioniPrimary (citable) accession number: O74421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2012
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.