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Protein

Chorismate synthase

Gene

SPCC1223.14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.

Cofactori

FMNH2By similarity

Pathwayi: chorismate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited (aro4), Putative phospho-2-dehydro-3-deoxyheptonate aldolase (SPAC24H6.10c)
  2. Pentafunctional AROM polypeptide (aro1)
  3. Pentafunctional AROM polypeptide (aro1)
  4. Pentafunctional AROM polypeptide (aro1)
  5. Pentafunctional AROM polypeptide (aro1)
  6. Pentafunctional AROM polypeptide (aro1)
  7. Chorismate synthase (SPCC1223.14)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00090.

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate synthase (EC:4.2.3.5)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene namesi
ORF Names:SPCC1223.14, SPCC297.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.14.
PomBaseiSPCC1223.14.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Chorismate synthasePRO_0000140703Add
BLAST

Proteomic databases

MaxQBiO74413.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

MINTiMINT-4678838.

Structurei

3D structure databases

ProteinModelPortaliO74413.
SMRiO74413. Positions 1-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chorismate synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000060335.
InParanoidiO74413.
KOiK01736.
OMAiMLSINAV.
OrthoDBiEOG7BP8C2.
PhylomeDBiO74413.

Family and domain databases

Gene3Di3.60.150.10. 1 hit.
HAMAPiMF_00300. Chorismate_synth.
InterProiIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
PANTHERiPTHR21085. PTHR21085. 2 hits.
PfamiPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMiSSF103263. SSF103263. 1 hit.
TIGRFAMsiTIGR00033. aroC. 1 hit.
PROSITEiPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFGTLFKV TTYGESHCKS VGCIVEGCPP GMNLTESDVQ VQLTRRRPGQ
60 70 80 90 100
SNLTTPRNEK DKVQIQSGTE FGVTLGTPIG MLVLNQDQKP HDYSDMDNYP
110 120 130 140 150
RPSHADYTYL EKYGVKASSG GGRSSARETI GRVAAGAIAE KYLLEAYGVE
160 170 180 190 200
IVAFVSSVGK IAIPLHETAS SAILDPEDDT FESPITAEYL KFLNKITREE
210 220 230 240 250
VDKTTVRCPH AATAAKMAER ITRARDNHDS IGGTVTCVIR NVPTGLGEPC
260 270 280 290 300
FDKLEAKLAH AMMSIPATKS FEIGSGREGC KVAGSKHNDL FYRNADTGKL
310 320 330 340 350
GTLTNNSGGV QGGISNGENV YFTIGFKSPA TIGVEQSTSR YDGSDGVLAA
360 370 380 390
KGRHDPCVVP RAIPIVEAMA ALVVMDAVMI QQSRIASRNL LPNAQ
Length:395
Mass (Da):42,325
Last modified:January 11, 2001 - v2
Checksum:iB551505160696DE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20883.1.
PIRiT41268.
RefSeqiNP_588359.2. NM_001023350.2.

Genome annotation databases

EnsemblFungiiSPCC1223.14.1; SPCC1223.14.1:pep; SPCC1223.14.
GeneIDi2538817.
KEGGispo:SPCC1223.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20883.1.
PIRiT41268.
RefSeqiNP_588359.2. NM_001023350.2.

3D structure databases

ProteinModelPortaliO74413.
SMRiO74413. Positions 1-384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4678838.

Proteomic databases

MaxQBiO74413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1223.14.1; SPCC1223.14.1:pep; SPCC1223.14.
GeneIDi2538817.
KEGGispo:SPCC1223.14.

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.14.
PomBaseiSPCC1223.14.

Phylogenomic databases

HOGENOMiHOG000060335.
InParanoidiO74413.
KOiK01736.
OMAiMLSINAV.
OrthoDBiEOG7BP8C2.
PhylomeDBiO74413.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00090.

Miscellaneous databases

NextBioi20799999.
PROiO74413.

Family and domain databases

Gene3Di3.60.150.10. 1 hit.
HAMAPiMF_00300. Chorismate_synth.
InterProiIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
PANTHERiPTHR21085. PTHR21085. 2 hits.
PfamiPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMiSSF103263. SSF103263. 1 hit.
TIGRFAMsiTIGR00033. aroC. 1 hit.
PROSITEiPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiAROC_SCHPO
AccessioniPrimary (citable) accession number: O74413
Secondary accession number(s): Q9Y7Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 11, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.